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Merck
CN

1270480

USP

FTY720

United States Pharmacopeia (USP) Reference Standard

别名:

2-氨基-2- [2-(4-辛基-苯基)-乙基]-丙烷-1,3-二醇 盐酸盐, 芬戈莫德 盐酸盐

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关于此项目

经验公式(希尔记法):
C19H33NO2 · HCl
化学文摘社编号:
分子量:
343.93
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

API family

fingolimod

form

powder

manufacturer/tradename

USP

storage condition

protect from light

color

white

solubility

DMSO: soluble, ethyl acetate: soluble, water: soluble

application(s)

pharmaceutical

storage temp.

2-8°C

SMILES string

Cl.NC(CO)(CO)CCc1ccc(cc1)CCCCCCCC

InChI

1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H

InChI key

SWZTYAVBMYWFGS-UHFFFAOYSA-N

General description

Fingolimod Hydrochloride (fingolimod HCl), an S1P-receptor modulator, belongs to the class of synthetic glucocorticoid steroid drugs.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Find answers to frequently asked questions on USP products in USP FAQs.

Application

Fingolimod Hydrochloride USP reference standard may be used to quantify the analyte in gel, capsule and other pharmaceutical formulations, active pharmaceutical ingredient (API) and pharmaceutical dosage forms by liquid chromatography (LC) based techniques.

Biochem/physiol Actions

FTY720是一种免疫调节药物以及1-磷酸鞘氨醇(S1P)受体的调节剂。 鞘氨醇激酶对FTY270的磷酸化可导致S1P1R的内化,从而螯合淋巴结中的淋巴细胞,阻止它们参与自身免疫反应。 临床上,它已被批准用于治疗多发性硬化症(MS)。研究显示其可通过抑制S1PR阻断和逆转紫杉醇诱导的化疗诱导的周围神经病变(CIPN),并可抑制小鼠脑海马中组蛋白脱乙酰酶的活性,从而调节记忆。
FTY720是一种免疫调节药物,可作为鞘氨醇-1-磷酸(S1P)受体的调节剂。

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.


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pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

STOT RE 2

target_organs

Immune system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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