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经验公式（希尔记法）:
C19H33NO2 · HCl
化学文摘社编号:
分子量:
343.93
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
SMILES string
Cl.NC(CO)(CO)CCc1ccc(cc1)CCCCCCCC
InChI
1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChI key
SWZTYAVBMYWFGS-UHFFFAOYSA-N
biological source
synthetic
agency
USP
API family
fingolimod
form
powder
manufacturer/tradename
USP
storage condition
protect from light
color
white
solubility
DMSO: soluble, ethyl acetate: soluble, water: soluble
application(s)
pharmaceutical
storage temp.
2-8°C
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General description
Fingolimod Hydrochloride (fingolimod HCl), an S1P-receptor modulator, belongs to the class of synthetic glucocorticoid steroid drugs.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Fingolimod Hydrochloride USP reference standard may be used to quantify the analyte in gel, capsule and other pharmaceutical formulations, active pharmaceutical ingredient (API) and pharmaceutical dosage forms by liquid chromatography (LC) based techniques.
Biochem/physiol Actions
FTY720是一种免疫调节药物以及1-磷酸鞘氨醇（S1P）受体的调节剂。 鞘氨醇激酶对FTY270的磷酸化可导致S1P1R的内化，从而螯合淋巴结中的淋巴细胞，阻止它们参与自身免疫反应。 临床上，它已被批准用于治疗多发性硬化症（MS）。研究显示其可通过抑制S1PR阻断和逆转紫杉醇诱导的化疗诱导的周围神经病变（CIPN），并可抑制小鼠脑海马中组蛋白脱乙酰酶的活性，从而调节记忆。
FTY720是一种免疫调节药物，可作为鞘氨醇-1-磷酸（S1P）受体的调节剂。
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
pcodes
Hazard Classifications
STOT RE 2
target_organs
Immune system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Fingolimod Hydrochloride
Fingolimod Hydrochloride USP Monograph; USP42-NF37:United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(6)(1), 1849-1849 (2020)
Rapid determination of fingolimod hydrochloride-related Substances and degradation products in API and pharmaceutical dosage forms by use of a stability-indicating UPLC method
Rajan N and Basha KA
Chromatographia, 77(21-22), 1545-1552 (2014)
A randomized, open-label study assessing the bioequivalence of two formulations of Fingolimod 0.5 mg in healthy subjects
Tanguay M, et al.
AAPS Open, 4(1), 3-3 (2018)
Sphingosine 1-phosphate receptor 1 as a useful target for treatment of multiple sclerosis
Chiba K and Adachi K
Pharmaceuticals (Basel, Switzerland), 5(5), 514-528 (2012)
Solubility of dexamethasone in supercritical carbon dioxide
Chim RB, et al.
Journal of Chemical and Engineering Data, 57(12), 3756-3760 (2012)
相关内容
High-Performance Liquid Chromatography method ensures total chromatographic purity analysis of Fingolimod Hydrochloride, offering rapid accuracy.
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