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Merck
CN

1327000

USP

硫酸羟氯喹

United States Pharmacopeia (USP) Reference Standard

别名:

7-氯-4-[4-（N-乙基-N-b-羟乙基氨基）-1-甲基丁氨基] 喹啉硫酸盐

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关于此项目

经验公式（希尔记法）:
C18H26ClN3O · H2SO4
化学文摘社编号:
747-36-4
分子量:
433.95
NACRES:
NA.24
PubChem Substance ID:
329750122
UNSPSC Code:
41116107
EC Number:
212-019-3
MDL number:
MFCD00078203

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产品名称

硫酸羟氯喹, United States Pharmacopeia (USP) Reference Standard

format

neat

InChI key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

SMILES string

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

API family

hydroxychloroquine

packaging

pkg of 200 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white to off-white

pH

3.5-5.5 (1% in aqueous solution, pH <6.0)

mp

388.4 °F (198°C; 240°C)

solubility

chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
water: soluble

application(s)

pharmaceutical (small molecule)

Gene Information

human ... TLR7(51284), TLR9(54106)

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相关类别

Biochem/physiol Actions

硫酸羟氯喹是一种抗炎（通过肿瘤坏死因子）、疾病调节抗风湿药物（DMARD）和血红素聚合酶抑制剂。
硫酸羟氯喹是一种抗炎（通过肿瘤坏死因子）、疾病调节抗风湿药物（DMARD）和血红素聚合酶抑制剂。 它可用于治疗疟疾。

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Hydroxychloroquine sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Hydroxychloroquine Sulfate Tablets
  • Hydroxychloroquine Sulfate Compounded Oral Suspension
  • Chloroquine Phosphate

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Hydroxychloroquine Sulfate is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Chloroquine Phosphate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)
Seminars in Arthritis and Rheumatism, 43(2), 264-272 (2013)
Hydroxychloroquine Sulfate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(2) (2021)
Hydroxychloroquine Sulfate Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(3) (2022)
Jacques-Eric Gottenberg et al.
JAMA, 312(3), 249-258 (2014-07-17)
Primary Sjögren syndrome is a systemic autoimmune disease characterized by mouth and eye dryness, pain, and fatigue. Hydroxychloroquine is the most frequently prescribed immunosuppressant for the syndrome. However, evidence regarding its efficacy is limited. To evaluate the efficacy of hydroxychloroquine
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实验方案

Chloroquine Phosphate HPLC Assay & Impurity Profiling

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

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