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Merck
CN

1347609

USP

伊立替康 盐酸盐

United States Pharmacopeia (USP) Reference Standard

别名:

Irinotecan monohydrochloride trihydrate, [1,4′-Bipiperidine]-1′-carboxylic acid (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester monohydrochloride trihydrate

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关于此项目

经验公式（希尔记法）:
C33H38N4O6 · HCl · 3H2O
化学文摘社编号:
136572-09-3
分子量:
677.18
MDL number:
MFCD01765731
UNSPSC Code:
41116107
NACRES:
NA.24

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产品名称

伊立替康 盐酸盐, United States Pharmacopeia (USP) Reference Standard

SMILES string

[Cl-].N21Cc3c(nc5c(c3CC)cc(cc5)OC(=O)N6CCC(CC6)N7CCCCC7)C2=CC4=C(COC(=O)[C@]4(O)CC)C1=O.O.O.O.[H+]

InChI

1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1

InChI key

KLEAIHJJLUAXIQ-JDRGBKBRSA-N

grade

pharmaceutical primary standard

API family

irinotecan

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Irinotecan hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Irinotecan Hydrochloride Injection

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Eetmad A Arafat et al.
Oxidative medicine and cellular longevity, 2021, 9690047-9690047 (2021-10-12)
Oral mucositis is the most debilitating and troublesome adverse effect of irinotecan (CPT-11) treatment. It adversely affects the patient quality of life. The aim of this work was to study the histological, immunohistochemical, and molecular changes in the oral mucosa

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