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文件

1370000

USP

洛哌丁胺盐酸盐

Name: 洛哌丁胺 盐酸盐
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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别名:

4-（ p -氯苯基）-4-羟基- N,N -二甲基-α,α-二苯基-1-哌啶丁酰胺盐酸盐

经验公式（希尔记法）:

C₂₉H₃₃ClN₂O₂ · HCl

CAS号:

34552-83-5

分子量:

513.50

MDL编号:

MFCD00058581

PubChem化学物质编号:

329750255

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

loperamide

制造商/商品名称

USP

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4

InChI

1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

InChI key

PGYPOBZJRVSMDS-UHFFFAOYSA-N

基因信息

human ... OPRM1(4988)

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应用

Loperamide hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

L0750000

洛哌丁胺盐酸盐, European Pharmacopoeia (EP) Reference Standard

Y0000341

洛哌丁胺一水合物, European Pharmacopoeia (EP) Reference Standard

1370065

PHR2916

象形图

GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P301 + P330 + P331 + P310

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Disposition and metabolism of [14C]loperamide in rats.

H Miyazaki et al.

European journal of drug metabolism and pharmacokinetics, 4(4), 199-206 (1979-01-01)

Following oral administration of [14C]loperamide hydrochloride in 1 mg/kg to rats, plasma levels of radioactivity reached maximum at 4 hrs and decreased with a half-life of 4.1 hrs. Radioactivity in 96-hr feces accounted for 95% of the dose, with 30%

Synergistic effect of fermented rice extracts on the probiotic and laxative properties of yoghurt in rats with loperamide-induced constipation.

Jae-Suk Choi et al.

Evidence-based complementary and alternative medicine : eCAM, 2014, 878503-878503 (2014-09-13)

Aim. The objective was to evaluate the synergistic effects of fermented rice extracts (FRe) on the laxative and probiotic properties of yoghurt in rats with loperamide-induced constipation. Methods. After constipation induction, yoghurt containing FRe (BFRe; 0.05%, 0.1%, or 1%) was

Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar.

William C Kreisl et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(1), 82-87 (2014-12-17)

The permeability-glycoprotein (P-gp) efflux transporter is densely expressed at the blood-brain barrier, and its resultant spare capacity requires substantial blockade to increase the uptake of avid substrates, blunting the ability of investigators to measure clinically meaningful alterations in P-gp function.

Loperamide hydrochloride.

L M Daugherty

American pharmacy, NS30(12), 45-48 (1990-12-01)

Chronic spinal infusion of loperamide alleviates postsurgical pain in rats.

Rakesh Kumar et al.

Indian journal of experimental biology, 52(4), 317-322 (2014-04-30)

Plantar incision in rat generates spontaneous pain behaviour. The opioid drug, morphine used to treat postsurgical pain produces tolerance after long-term administration. Loperamide, a potent mu-opioid agonist, has documented analgesic action in various pain conditions. However, loperamide analgesia and associated

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洛哌丁胺 盐酸盐