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文件

1443500

USP

（±）-咪康唑硝酸盐

Name: （±）-咪康唑 硝酸盐
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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别名:

1-（2,4-二氯-β-[（2,4-二氯苄基）氧] 苯乙基 ] 咪唑

经验公式（希尔记法）:

C₁₈H₁₄Cl₄N₂O · HNO₃

CAS号:

22832-87-7

分子量:

479.14

MDL编号:

MFCD00058161

PubChem化学物质编号:

329750464

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

miconazole

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

格式

neat

SMILES string

ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O

InChI

1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)

InChI key

MCCACAIVAXEFAL-UHFFFAOYSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Miconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

生化/生理作用

咪康唑与 14-α 相互作用脱甲基酶，一种麦角固醇生物合成所必需的细胞色素 P-450 酶。麦角固醇的抑制导致细胞通透性增加引起细胞内容物渗漏。咪康唑还可能抑制内源性呼吸，与细胞膜中的磷脂相互作用，抑制酵母菌转化为菌丝形式，抑制嘌呤摄取，干扰甘油三酯和磷脂的生物合成。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

1443431

1443464

1443497

BP253

（±）-咪康唑硝酸盐, British Pharmacopoeia (BP) Reference Standard

BP884

咪康唑杂质A, British Pharmacopoeia (BP) Reference Standard

PHR9002

1-[(2RS)-2-(Benzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazolium nitrate, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

象形图

GHS07

警示用语：

Warning

危险声明

H302 - H317

预防措施声明

P280 - P301 + P312 + P330 - P302 + P352

危险分类

Acute Tox. 4 Oral - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Miconazole activity against Candida biofilms developed on acrylic discs.

S Gebremedhin et al.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(4), 593-600 (2014-09-03)

Oral candidiasis in the form of Candida-associated denture stomatitis (CaDS) is associated with Candida adhesion and biofilm formation on the fitting surface of poly (methyl methacrylate) (PMMA) dentures. Candida biofilms show considerable resistance to most conventional antifungal agents, a phenomenon

Multicenter, double-blind, parallel group study investigating the non-inferiority of efficacy and safety of a 2% miconazole nitrate shampoo in comparison with a 2% ketoconazole shampoo in the treatment of seborrhoeic dermatitis of the scalp.

Stanislaw A Buechner

The Journal of dermatological treatment, 25(3), 226-231 (2013-04-06)

This study investigated the non-inferiority of efficacy and tolerance of 2% miconazole nitrate shampoo in comparison with 2% ketoconazole shampoo in the treatment of scalp seborrheic dermatitis. A randomized, double-blind, comparative, parallel group, multicenter study was done. A total of

NO-donating oximes relax corpora cavernosa through mechanisms other than those involved in arterial relaxation.

Bart Pauwels et al.

The journal of sexual medicine, 11(7), 1664-1674 (2014-05-21)

Erectile dysfunction (ED), as well as many cardiovascular diseases, is associated with impaired nitric oxide (NO) bioavailability. Recently, oxime derivatives have emerged as vasodilators due to their NO-donating capacities. However, whether these oximes offer therapeutic perspectives as an alternative NO

Antimicrobial activity of ibuprofen: new perspectives on an "Old" non-antibiotic drug.

Jelena Obad et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 93-98 (2015-02-25)

Pharmaceutical industry has been encountering antimicrobial activity of non-antibiotics during suitability tests carried out prior to routine pharmacopoeial microbiological purity analysis of finished dosage forms. These properties are usually ignored or perceived as a nuisance during pharmaceutical analysis. The aim

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（±）-咪康唑 硝酸盐