SMILES string
Clc1cc2c(cc1)O\C(=C3\C=C(C=CC\3=O)NC(=O)C(C)C)\N2
InChI
1S/C17H15ClN2O3/c1-9(2)16(22)19-11-4-5-14(21)12(8-11)17-20-13-7-10(18)3-6-15(13)23-17/h3-9,20H,1-2H3,(H,19,22)/b17-12-
InChI key
YGMGVHYZWYRTJJ-ATVHPVEESA-N
grade
pharmaceutical primary standard
API family
nicotine
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Nicotine bitartrate dihydrate USP reference standard for use in specified quality tests and assays.
Also used to prepare standard, system suitability, sensitivity, and standard stock solution for assay, identification, performance test, and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):
Also used to prepare standard, system suitability, sensitivity, and standard stock solution for assay, identification, performance test, and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):
- Nicotine
- Nicotine Polacrilex
- Nicotine Transdermal System
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - STOT RE 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Nicotine Transdermal System
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(2), 3153-3153 (2021)
Nicotine
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(5) (2022)
Cheng Xiao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 3734-3746 (2015-03-06)
The glutamatergic subthalamic nucleus (STN) exerts control over motor output through nuclei of the basal ganglia. High-frequency electrical stimuli in the STN effectively alleviate motor symptoms in movement disorders, and cholinergic stimulation boosts this effect. To gain knowledge about the
Nicotine Polacrilex
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(1), 3156-3156 (2020)
Brandon J Henderson et al.
The Journal of general physiology, 143(1), 51-66 (2014-01-01)
Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson's disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in
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