Merck
CN
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文件

1576800

USP

没食子酸丙酯

United States Pharmacopeia (USP) Reference Standard

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别名:
3,4,5-三羟基苯甲酸丙酯, Tenox PG
线性分子式:
3,4,5-(HO)3C6H2CO2CH2CH2CH3
CAS号:
121-79-9
分子量:
212.20
Beilstein:
1877976
MDL编号:
MFCD00002196
PubChem化学物质编号:
329750994
NACRES:
NA.24

等级

pharmaceutical primary standard

API family

propyl gallate

manufacturer/tradename

USP

mp

146-149 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

SMILES string

CCCOC(=O)c1cc(O)c(O)c(O)c1

InChI

1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3

InChI key

ZTHYODDOHIVTJV-UHFFFAOYSA-N

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

在荧光显微术中用作抗淬灭剂，以减少罗丹明和荧光素等荧光探针的光漂白。

生化/生理作用

表现出抗菌活性的抗氧化剂。据报道，五倍子酸丙酯是一种有效的、抗氧化剂类体内外护肝剂。另据证明，它能防止神经元凋亡，阻止暴露于 FeSO4/GA 的神经元死亡，以及在一定程度上防止 TNF-诱导的内皮细胞凋亡。
表现出抗菌活性的抗氧化剂。据报道，五倍子酸丙酯是一种有效的、抗氧化剂类体内外护肝剂。另据证明，它能防止神经元凋亡，阻止暴露于 FeSO4/GA 的神经元死亡，以及在一定程度上防止 TNF-诱导的内皮细胞凋亡。但是，当五倍子酸丙酯浓度高于 0.25μM，同时存在 5μM 及更高浓度的铜时，会诱导 DNA 单链断裂。另有报道称，使用浓度 >1mM 的五倍子酸丙酯进行离体大鼠肝细胞培养会诱导细胞死亡，而 >0.5mM 的较低浓度的五倍子酸丙酯导致了可溶性低分子量 DNA 片段的 ladder 形成，这是细胞凋亡的特征。

重悬

用甘油:PBS (9:1) 配成 0.1M 的溶液

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

储存分类代码

13 - Non Combustible Solids

WGK

WGK 2

闪点(°F)

368.6 °F - closed cup

闪点(°C)

187 °C - closed cup

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International journal of toxicology, 26 Suppl 3, 89-118 (2008-02-19)
Propyl Gallate is the n-propyl ester of gallic acid (3,4,5-trihydroxybenzoic acid). It is soluble in ethanol, ethyl ether, oil, lard, and aqueous solutions of polyethylene glycol (PEG) ethers of cetyl alcohol, but only slightly soluble in water. Propyl Gallate currently
Cheng-Kun Du et al.
Life sciences, 109(1), 15-19 (2014-06-17)
We have previously demonstrated that propyl gallate has a Ca(2+) sensitizing effect on the force generation in membrane-permeabilized (skinned) cardiac muscle fibers. However, in vivo beneficial effects of propyl gallate as a novel Ca(2+) sensitizer remain uncertain. In the present
Amanda Psyrri et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(11), 3023-3032 (2014-04-05)
We sought to evaluate the correlation between tissue biomarker expression (using standardized, quantitative immunofluorescence) and clinical outcome in the E2303 trial. Sixty-three eligible patients with operable stage III/IV head and neck squamous cell cancer (HNSCC) participated in the Eastern Cooperative
Liliana O Rocha et al.
PloS one, 9(4), e92189-e92189 (2014-04-18)
Bacterial antagonists used as biocontrol agents represent part of an integrated management program to reduce pesticides in the environment. Bacillus thuringiensis is considered a good alternative as a biocontrol agent for suppressing plant pathogens such as Fusarium. In this study
T Lu et al.
Poultry science, 93(7), 1658-1666 (2014-05-28)
The aim of the current study was to determine the effects of a dietary antioxidant blend and vitamin E on fatty acid profile, inflammatory response, and liver function. Cobb 500 male broilers (n = 1,200, d 0) were randomly distributed
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