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经验公式（希尔记法）:
C14H21N3O2S · C4H6O4
化学文摘社编号:
分子量:
413.49
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
Sumatriptan succinate, United States Pharmacopeia (USP) Reference Standard
InChI
1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
SMILES string
OC(=O)CCC(O)=O.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
InChI key
PORMUFZNYQJOEI-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
sumatriptan
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
−20°C
Gene Information
human ... HTR1B(3351), HTR1D(3352)
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Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Sumatriptan succinate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Sumatriptan
- Sumatriptan Nasal Spray
- Sumatriptan Tablets
- Sumatriptan Injection
- Sumatriptan Compounded Oral Suspension
Biochem/physiol Actions
Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xiaojuan Wang et al.
Journal of molecular neuroscience : MN, 54(2), 164-170 (2014-03-04)
Neurogenic dural vasodilation has been demonstrated to play an important role in migraine. 5-HT(7) receptors have been found on trigeminal nerve endings and middle meningeal arteries and demonstrated involved in the dilatation of meningeal arteries. The aim of the present
Y Iwasawa et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 117(6), 387-393 (2001-07-05)
Sumatriptan succinate (SMT) was a highly specific 5-HT1-receptor agonist. It showed high affinity only for 5-HT but no affinity for other neurotransmitter receptors such as muscarinic, dopamine D1, D2, adrenergic alpha 1, alpha 2, and beta. Furthermore, it was highly
Luana Lionetto et al.
Expert opinion on pharmacotherapy, 13(16), 2369-2380 (2012-09-28)
Migraine is a common neurovascular disorder characterized by recurrent episodes of disabling headache, autonomic nervous system dysfunction, and in some patients, neurological aura symptoms. Triptans are frequently prescribed drugs for the treatment of the acute migraine attack, considering their capability
Dalapathi Gugulothu et al.
Drug development and industrial pharmacy, 41(3), 398-405 (2014-01-05)
The present investigation is aimed at development and characterization of sumatriptan succinate orodispersible tablets (ODTs) prepared by freeze drying technology. The tablet excipients were screened and the composition was optimized based on parameters which involved general appearance, tablet size and
Jessica L Knittel et al.
Journal of analytical toxicology, 39(1), 75-79 (2014-10-18)
A multidrug fatality involving sumatriptan is reported. Sumatriptan is a tryptamine derivative that acts at 5-HT(1B/1D) receptors and is used for the treatment of migraines. The decedent was a 21-year-old white female found dead in bed by her spouse. No
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