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1643419

USP

替米沙坦

Name: 替米沙坦
Brand: USP

United States Pharmacopeia (USP) Reference Standard

别名:

4′[(1,4′-二甲基-2′-丙基 [2,6′-双-1H-苯并咪唑 ]-1′-基）甲基 ] [1,1′-联苯基 ]-2-羧酸, BIBR 277

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关于此项目

经验公式（希尔记法）:

C₃₃H₃₀N₄O₂

化学文摘社编号:

144701-48-4

分子量:

514.62

NACRES:

NA.24

PubChem Substance ID:

329751227

UNSPSC Code:

41116107

MDL number:

MFCD00918125

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属性

grade

pharmaceutical primary standard

API family

telmisartan

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)-c4ccccc4C(O)=O)-c5nc6ccccc6n5C

InChI

1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)

InChI key

RMMXLENWKUUMAY-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Telmisartan USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

替米沙坦是一种非肽类 ₁ 血管紧张素受体拮抗剂。

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell.

Habib Eslami et al.

Neuroscience letters, 558, 31-36 (2013-11-12)

Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase

Pharmacokinetic interaction between rosuvastatin and telmisartan in healthy Korean male volunteers: a randomized, open-label, two-period, crossover, multiple-dose study.

Mijeong Son et al.

Clinical therapeutics, 36(8), 1147-1158 (2014-07-07)

Rosuvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, and telmisartan, an angiotensin receptor blocker, are commonly prescribed in combination for the treatment of dyslipidemia accompanied by hypertension. However, the nature of the pharmacokinetic interaction between the 2 drugs is not clearly

Telmisartan attenuates the inflamed mesenteric adipose tissue in spontaneous colitis by mechanisms involving regulation of neurotensin/microRNA-155 pathway.

Yi Li et al.

Biochemical pharmacology, 93(4), 461-469 (2015-01-13)

Mesenteric adipose tissue hypertrophy is unique to Crohn's disease while the molecular basis of the crosstalk between MAT and the intestinal inflammation is largely unknown. Telmisartan is an angiotensin II type 1 receptor blocker and a peroxisome proliferator-activated receptor-receptor-γ agonist

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全球贸易项目编号

货号	GTIN
1643419-200MG	04061838748126