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关于此项目
经验公式（希尔记法）:
C18H37N5O9
化学文摘社编号:
分子量:
467.51
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1357507
产品名称
Tobramycin, United States Pharmacopeia (USP) Reference Standard
InChI
1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1
SMILES string
NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
InChI key
NLVFBUXFDBBNBW-SNGYORCQSA-N
grade
pharmaceutical primary standard
API family
tobramycin
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
It is intended to be used as a USP reference standard in specified quality tests and assays.(1)
Also used to prepare the standard solution for identification and assay of tobramycin and its different dosage forms using thin-layer chromatography (TLC) and liquid chromatography (LC) combined with UV detection at 365 nm respectively, as prescribed in the United States Pharmacopeia (USP) for the following monographs:
Also used to prepare the standard solution for identification and assay of tobramycin and its different dosage forms using thin-layer chromatography (TLC) and liquid chromatography (LC) combined with UV detection at 365 nm respectively, as prescribed in the United States Pharmacopeia (USP) for the following monographs:
- Tobramycin
- Tobramycin for Injection
- Tobramycin Ophthalmic Ointment
- Tobramycin Ophthalmic Solution
- Tobramycin Injection
- Tobramycin Sulfate
- Tobramycin and Dexamethasone Ophthalmic Suspension
- Tobramycin Inhalation Solution
- Tobramycin and Fluorometholone Acetate Ophthalmic Suspension
- Tobramycin and Dexamethasone Ophthalmic Ointment
Biochem/physiol Actions
Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Tobramycin and Fluorometholone Acetate Ophthalmic Suspension
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(5), 4412-4412 (2013)
Tobramycin and Dexamethasone Ophthalmic Suspension
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 4414-4414 (2013)
Tobramycin
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(2), 4401-4401 (2018)
Tobramycin for Injection
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 4403-4403 (2018)
Tobramycin Sulfate
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 4414-4414 (2018)
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