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Deok-Seon Ryu et al.
International journal of oncology, 45(1), 459-469 (2014-05-03)
We investigated the anticancer mechanisms of the ethylacetate (EtOAc) fraction from Orostachys japonicus in human gastric cancer (AGS) cells. Flow cytometric analysis revealed that the number of total apoptotic cells following treatment with the EtOAc fraction increased in a dose-dependent
Cordula Stillhart et al.
Pharmaceutical research, 31(12), 3426-3444 (2014-06-26)
In vitro lipolysis is widely utilized for predicting in vivo performance of oral lipid-based formulations (LBFs). However, evaluation of LBFs in the absence of an absorption sink may have limited in vivo relevance. This study aimed at employing biopharmaceutical modeling
B E Butterworth et al.
Toxicology letters, 82-83, 23-26 (1995-12-01)
Chloroform produces cancer by a nongenotoxic-cytotoxic mode of action, with no increased cancer risk expected at noncytotoxic doses. The default risk assessment for inhaled chloroform relies on liver tumor incidence from a gavage study with female B6C3F1 mice and estimates
Nolwenn Callac et al.
Extremophiles : life under extreme conditions, 19(3), 597-617 (2015-03-18)
Active hydrothermal chimneys host diverse microbial communities exhibiting various metabolisms including those involved in various biogeochemical cycles. To investigate microbe-mineral-fluid interactions in hydrothermal chimney and the driver of microbial diversity, a cultural approach using a gas-lift bioreactor was chosen. An
Cynthia D Franci et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 181, 1-8 (2014-12-03)
Reproductive success of seabirds is tightly associated with availability of their prey for which the spatiotemporal distribution may be influenced by sea surface temperature (SST) fluctuations. The objective of this study was to investigate whether Northern gannets (Morus bassanus) from
Nikolaos Nikogeorgos et al.
Soft matter, 11(3), 489-498 (2014-11-22)
A synergetic lubricating effect between porcine gastric mucin (PGM) and chitosan based on their mucoadhesive interaction is reported at a hydrophobic interface comprised of self-mated polydimethylsiloxane (PDMS) surfaces. In acidic solution (pH 3.2) and low concentrations (0.1 mg mL(-1)), the
Gregory J Hardy et al.
Biochimica et biophysica acta, 1838(10), 2662-2669 (2014-07-16)
The rare, broadly neutralizing antibodies, 4E10 and 2F5, that target the HIV-1 membrane proximal external region also associate with HIV-1 membrane lipids as part of a required first-step in HIV-1 neutralization. HIV-1 virions have high concentration of cholesterol and sphingomyelin
Snezana Agatonovic-Kustrin et al.
Journal of chromatography. A, 1385, 103-110 (2015-02-11)
The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical as a post-chromatographic derivatization agent to compare the free radical scavenging activities
Anke C Stöhr et al.
PloS one, 10(2), e0118633-e0118633 (2015-02-24)
Ranaviruses in amphibians and fish are considered emerging pathogens and several isolates have been extensively characterized in different studies. Ranaviruses have also been detected in reptiles with increasing frequency, but the role of reptilian hosts is still unclear and only
A Ahmad et al.
Letters in applied microbiology, 60(1), 8-19 (2014-10-28)
Studies describing the use of essential oil constituents as antimicrobial agents have steadily increased; however, some phyto-constituents are often overlooked due to unfavourable minimum inhibitory concentration (MIC) values. Virulence depends on transcriptional factors which are regulated by cell-to-cell communication called
Jatin Mehta et al.
PloS one, 10(3), e0120622-e0120622 (2015-03-18)
Androgen Receptor (AR) is an essential transcription factor for the development of secondary sex characteristics, spermatogenesis and carcinogenesis. Recently AR has been implicated in the development and progression of breast and prostate cancers. Although some of the functions of the
Takuya Uchino et al.
Carbohydrate research, 402, 118-123 (2014-12-17)
The 3,6-O-(o-xylylene) bridge locks the conformation of glucopyranose to an axial-rich form. Although the conformational lock induces complete β-selectivity in a glycosylation reaction, the leaving group of the glycosyl donor is limited to fluorine. On the other hand, the bridge
Olivier Morales et al.
British journal of haematology, 166(6), 875-890 (2014-07-22)
Epstein-Barr Virus (EBV) is present in the neoplastic cells of around 20-30% of patients with Hodgkin Lymphoma (HL). Although, an immunosuppressive environment is currently described in HL patients, little is known concerning the regulatory mechanism induced by EBV proteins expression
Michalina Kosiorek et al.
PloS one, 9(6), e99118-e99118 (2014-06-07)
The bulk of human genes undergo alternative splicing (AS) upon response to physiological stimuli. AS is a great source of protein diversity and biological processes and is associated with the development of many diseases. Pheochromocytoma is a neuroendocrine tumor, characterized
Kwan Wee Tan et al.
ACS nano, 8(5), 4730-4739 (2014-04-02)
Structure control in solution-processed hybrid perovskites is crucial to design and fabricate highly efficient solar cells. Here, we utilize in situ grazing incidence wide-angle X-ray scattering and scanning electron microscopy to investigate the structural evolution and film morphologies of methylammonium
Keisuke Ohsumi et al.
The Journal of antibiotics, 67(10), 707-711 (2014-05-29)
A novel antifungal agent, AS2077715, was isolated from the fermentation broth of a fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent
Javier Casas et al.
Nature communications, 5, 5624-5624 (2014-11-28)
The earliest molecular events in T-cell recognition have not yet been fully described, and the initial T-cell receptor (TCR)-triggering mechanism remains a subject of controversy. Here, using total internal reflection/Forster resonance energy transfer microscopy, we observe a two-stage interaction between
Anna Färnert et al.
Malaria journal, 13, 459-459 (2014-11-27)
Assessments of the epidemiology of malaria over time are needed to understand changes in transmission and guide control and elimination strategies. A longitudinal population study was established in 1985 in Nyamisati village in the Rufiji River Delta, Tanzania. A physician
Takeshi Nakajima et al.
Investigative ophthalmology & visual science, 55(8), 5278-5283 (2014-07-24)
Activation of calpains (calpain 2 and Lp82) in rodent lenses readily causes proteolysis and cataract formation. In contrast, primate lenses are quite resistant to activation of calpains. The hypothesis is that high levels of human endogenous calpain inhibitor, calpastatin (CS)
T A Ignatowski et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 10(1), 136-152 (2015-01-22)
Opiates act on the dopaminergic system of the brain and perturb 32 kDa dopamine and adenosine 3', 5'-monophosphate-regulated phosphoprotein (DARPP-32) function. The DARPP-32 mediated inhibition of protein phosphatase-1 (PP-1) and modulation of transcriptional factor CREB is critical to the changes
Richard McClure et al.
Journal of Alzheimer's disease : JAD, 44(1), 283-295 (2014-09-18)
Curcumin is a promising compound that can be used as a theranostic agent to aid research in Alzheimer's disease. Beyond its ability to bind to amyloid plaques, the compound can also cross the blood-brain barrier. Presently, curcumin can be applied
Monika Chauhan et al.
Bioorganic chemistry, 58, 1-10 (2014-12-03)
Design, microwave-assisted synthesis of novel 4-aryl (alkyl)amino-3-nitroquinoline (1a-1l) and 2,4-diaryl (dialkyl)amino-3-nitroquinolines (2a-2k and 3a) via regioselective and complete nucleophilic substitution of 2,4-dichloro-3-nitroquinoline, respectively in water are presented. The newly synthesized compounds were evaluated for the first time for antiproliferative activity
M Rauner et al.
Bone, 64, 281-287 (2014-05-02)
Cathepsin S is a cysteine protease that controls adipocyte differentiation and has been implicated in vascular and metabolic complications of obesity. Considering the inverse relation of osteoblasts and adipocytes and their mutual precursor cell, we hypothesized that cathepsin S may
Stevo Matijević et al.
Vojnosanitetski pregled, 69(12), 1101-1105 (2013-02-22)
Odontogenic keratocyst (OKC) is a rare developmental, epithelial and benign cyst of the jaws of odontogenic origin with high recurrence rates. The third molar region, especially the angle of the mandible and the ascending ramus are involved far more frequently
Terry Fei Fan Ng et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(47), 16842-16847 (2014-10-29)
Viruses preserved in ancient materials provide snapshots of past viral diversity and a means to trace viral evolution through time. Here, we use a metagenomics approach to identify filterable and nuclease-resistant nucleic acids preserved in 700-y-old caribou feces frozen in
Cheng Zhang et al.
Journal of chromatography. A, 1344, 15-22 (2014-04-29)
Novel cross-linked polymeric ionic liquid (PIL) bucky gels were formed by free-radical polymerization of polymerizable ionic liquids gelled with multi-walled carbon nanotubes (MWCNT) and used as sorbent coatings for solid-phase microextraction (SPME). The combination of PIL with MWCNTs significantly enhanced
Petter Olsson et al.
Journal of chromatography. A, 1369, 105-115 (2014-12-03)
This paper reports a simple chromatographic system to separate lipids classes as well as their molecular species. By the use of phenyl coated silica as stationary phase in combination with a simple mobile phase consisting of methanol and water, all
Christina Fieber et al.
PloS one, 10(3), e0119727-e0119727 (2015-03-11)
Innate immune recognition of the major human-specific Gram-positive pathogen Streptococcus pyogenes is not understood. Here we show that mice employ Toll-like receptor (TLR) 2- and TLR13-mediated recognition of S. pyogenes. These TLR pathways are non-redundant in the in vivo context
From chloroform to extract of meat: chemist and entrepreneur Liebig.
George S Bause
Anesthesiology, 119(1), 155-155 (2013-07-17)
Justin A Thornton et al.
Ophthalmic research, 53(3), 149-161 (2015-03-21)
Streptococcus pneumoniae (pneumococcus) is a potential cause of bacterial endophthalmitis in humans that can result in ocular morbidity. We sought to identify pneumococcal genes that are differentially expressed during growth in the vitreous humor of the eye in an experimental
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