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S Gabner et al.
Parasite immunology, 36(7), 277-291 (2014-04-08)
Infections of neonatal piglets with Cystoisospora suis are responsible for substantial economic losses in pig production. To investigate kinetics of T-cell populations, which are possibly involved in this infection, lymphocytes from blood, spleen, mesenteric lymph nodes and the jejunal mucosa
Shian-Ying Sung et al.
Oncotarget, 5(20), 9911-9929 (2014-10-09)
The L1 cell adhesion molecule (L1CAM) has been implicated in tumor progression of many types of cancers, but its role in prostate cancer and its application in targeted gene therapy have not been investigated. Herein, we demonstrated that the L1CAM
Li You et al.
Biochemical and biophysical research communications, 456(2), 598-604 (2014-12-10)
Osteoporosis is a metabolic disease in which a disruption of the balance between bone formation by osteoblasts and bone resorption by osteoclasts leads to the progressive deterioration of bone density and quality. Tissue engineering approaches to the treatment of osteoporosis
Tianming Yang et al.
European journal of medicinal chemistry, 92, 145-155 (2015-01-01)
Sirtuins are protein deacylases with regulatory roles in metabolism and stress response. Functionalized tetrahydro-1H-pyrido[4,3-b]indoles were identified as preferential sirtuin 2 inhibitors, with in vitro inhibitory potencies in the low micromolar concentrations (IC50 3-4 μM) for the more promising candidates. The functional relevance
Martin Bachman et al.
Nature chemistry, 6(12), 1049-1055 (2014-11-21)
5-Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present in the deoxyribonucleic acid (DNA) of most mammalian cells. Reduction of hmC levels in DNA is a hallmark of cancers. Elucidating the dynamics of this oxidation reaction and the
T Touvier et al.
Cell death & disease, 6, e1663-e1663 (2015-02-27)
Mitochondrial fission and fusion are essential processes in the maintenance of the skeletal muscle function. The contribution of these processes to muscle development has not been properly investigated in vivo because of the early lethality of the models generated so
Mustafa Ferzeyn Yavuzkir et al.
The Journal of international medical research, 42(3), 781-787 (2014-04-03)
To compare the mean platelet volume (MPV; a general marker of platelet activation) in groups of patients with and without hypertension and to analyse its relationship with left ventricular mass index (LVMI). This cross-sectional, observational study enrolled newly diagnosed patients
Iva Kulic et al.
The Journal of experimental medicine, 212(1), 37-52 (2014-12-17)
Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ
Ui-Jin Bae et al.
Experimental & molecular medicine, 46, e109-e109 (2014-08-12)
Hepatic ischemia/reperfusion (I/R) injury leads to oxidative stress and acute inflammatory responses that cause liver damage and have a considerable impact on the postoperative outcome. Much research has been performed to develop possible protective techniques. We aimed to investigate the
Jiayin Wang et al.
Scientific reports, 5, 9621-9621 (2015-04-11)
Galectin-1 (gal-1), a special lectin with high affinity to β-galactosides, is implicated in protection against ischemic brain injury. The present study investigated transplantation of gal-1-secreting neural stem cell (s-NSC) into ischemic brains and identified the mechanisms underlying protection. To accomplish
Petr Kosztyu et al.
Chemico-biological interactions, 219, 203-210 (2014-06-24)
The effect of ABCB1 (P-gp, (P-glycoprotein), MDR1) and ABCG2 (BCRP1, (breast cancer resistance protein 1)) expressions on cell resistance to daunorubicin (DRN), imatinib, and nilotinib was studied in human leukemia cells. We used a set of cells derived from a
David S Rowlands et al.
Physiological genomics, 46(20), 747-765 (2014-08-21)
Epigenomic regulation of the transcriptome by DNA methylation and posttranscriptional gene silencing by miRNAs are potential environmental modulators of skeletal muscle plasticity to chronic exercise in healthy and diseased populations. We utilized transcriptome networks to connect exercise-induced differential methylation and
David J Handelsman et al.
Endocrinology, 156(1), 400-405 (2014-11-05)
Accurate measurement of testosterone is important for reproductive endocrinology research, but the validity of direct (nonextraction) testosterone immunoassays, developed and validated for human serum, has not been appraised for application to mouse serum or steroidogenic tissue extracts. Testosterone was measured
Jianwei Zuo et al.
Oncology reports, 33(3), 1388-1394 (2015-01-13)
The aim of the present study was to investigate whether pristimerin affects the bone metastasis, stem cell characteristics and epithelial-mesenchymal transition (EMT) of prostate cancer (PCa) PC-3 cells subjected to hypoxia. The PC-3 cells were cultured under hypoxia or normoxia
Daniele Moretti et al.
PloS one, 10(2), e0117258-e0117258 (2015-02-07)
Calpain-3 is an intracellular cysteine protease, belonging to Calpain superfamily and predominantly expressed in skeletal muscle. In human melanoma cell lines and biopsies, we previously identified two novel splicing variants (hMp78 and hMp84) of Calpain-3 gene (CAPN3), which have a
Yuichi Ohnishi et al.
Oncology reports, 32(2), 780-786 (2014-06-14)
Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the underlying mechanisms remain unclear. In the present study, we characterized cetuximab-resistant oral squamous cell carcinoma
Petter Holland et al.
Traffic (Copenhagen, Denmark), 15(12), 1390-1405 (2014-09-13)
Mutations in the large BEACH domain-containing protein LYST causes Chediak-Higashi syndrome. The diagnostic hallmark is enlarged lysosomes and lysosome-related organelles in various cell types. Dysfunctional secretion of enlarged lysosome-related organelles has been observed in cells with mutations in LYST, but
J Juhasova et al.
Cellular and molecular neurobiology, 35(1), 57-70 (2014-12-10)
Expression of doublecortin (DCX), a 43-53 kDa microtubule binding protein, is frequently used as (i) an early neuronal marker to identify the stage of neuronal maturation of in vivo grafted neuronal precursors (NSCs), and (ii) a neuronal fate marker transiently
David B Beck et al.
Journal of proteome research, 13(12), 6135-6143 (2014-10-15)
Accurate and sensitive detection of protein-protein and protein-RNA interactions is key to understanding their biological functions. Traditional methods to identify these interactions require cell lysis and biochemical manipulations that exclude cellular compartments that cannot be solubilized under mild conditions. Here
N Panda et al.
Materials science & engineering. C, Materials for biological applications, 48, 521-532 (2015-01-13)
Biomaterials that stimulate cell attachment and proliferation without any surface modification (e.g. RGD coating) provide potent and cost effective scaffold for regenerative medicine. This study assessed the physico-chemical properties and cell supportive potential of a silk fibroin blend scaffold derived
A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b.
John B Johnson et al.
Journal of virology, 89(2), 989-998 (2014-10-31)
Complement is an innate immune system that most animal viruses must face during natural infections. Given that replication and dissemination of the highly pathogenic Nipah virus (NiV) include exposure to environments rich in complement factors, we tested the in vitro
Sakshi Mishra et al.
Toxicology and applied pharmacology, 279(2), 186-197 (2014-06-18)
Several toxicological manifestations of deoxynivalenol (DON), a mycotoxin, are well documented; however, dermal toxicity is not yet explored. The effect of topical application of DON to mice was studied using markers of skin proliferation, inflammation and tumor promotion. Single topical
Joungjwa Ahn et al.
Archives of pharmacal research, 37(6), 783-792 (2014-01-08)
Small-sized particles are more suitable for targeted delivery and are therapeutically more effective than large-sized particles. In this study, we investigated the anticancer effects of ultrafine particles of Ulmus davidiana var. japonica (ufUJ) on human gastric cancer cell lines SNU-1
José Gerardo Carneiro et al.
Basic & clinical pharmacology & toxicology, 115(4), 335-342 (2014-03-29)
Sulphated polysaccharides from marine algae are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of sulphated polysaccharides from the green marine alga Caulerpa mexicana (Cm-SPs) in nociceptive and inflammatory models in rodents. Cm-SPs (10
Arne H Smits et al.
Nucleic acids research, 42(15), 9880-9891 (2014-07-25)
While recent developments in genomic sequencing technology have enabled comprehensive transcriptome analyses of single cells, single cell proteomics has thus far been restricted to targeted studies. Here, we perform global absolute protein quantification of fertilized Xenopus laevis eggs using mass
Weronika Wituszyńska et al.
Plant, cell & environment, 38(2), 315-330 (2014-01-30)
As obligate photoautotrophs, plants are inevitably exposed to ultraviolet (UV) radiation. Because of stratospheric ozone depletion, UV has become more and more dangerous to the biosphere. Therefore, it is important to understand UV perception and signal transduction in plants. In
Hyeon Jin Kim et al.
Chemico-biological interactions, 219, 1-8 (2014-05-27)
Cucurbitacin-I is a triterpenoids found in medicinal plants and have diverse pharmacological and biological activities. In this study, the antitumor effects of cucurbitacin-I on colon cancer and possible roles in apoptosis and cell cycle arrest were investigated. Treatment of SW480
Yuwei Duan et al.
Drug delivery, 22(1), 50-57 (2014-01-15)
Although curcumin (CUR) can inhibit proliferation and induce apoptosis of tumors, the poor water solubility restricted its clinical application. The aim of this study was to improve the aqueous solubility of CUR and make more favorable changes to bioactivity by
Dana M Lord et al.
Biochemistry, 53(46), 7223-7231 (2014-11-08)
MqsR-controlled colanic acid and biofilm regulator (McbR, also known as YncC) is the protein product of a highly induced gene in early Escherichia coli biofilm development and has been regarded as an attractive target for blocking biofilm formation. This protein
Diana Gaspar et al.
Biochimica et biophysica acta, 1853(2), 308-316 (2014-12-03)
Cancer remains a major cause of morbidity and mortality worldwide. Although progress has been made regarding chemotherapeutic agents, new therapies that combine increased selectivity and efficacy with low resistance are still needed. In the search for new anticancer agents, therapies
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