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Jorge S Valadas et al.
Journal of neurochemistry, 123(6), 1030-1040 (2012-10-13)
In situations of hypoxia, glutamate excitotoxicity induces neuronal death. The release of extracellular adenosine is also triggered and is accompanied by an increase of the stress mediator, corticotrophin-releasing factor (CRF). Adenosine A(2A) receptors contribute to glutamate excitoxicity and their blockade
Jonathan Lezmy et al.
Science (New York, N.Y.), 374(6565), eabh2858-eabh2858 (2021-10-15)
[Figure: see text].
Kate Sokolina et al.
Molecular systems biology, 13(3), 918-918 (2017-03-17)
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global
Stefka Gyoneva et al.
Neurobiology of disease, 67, 191-202 (2014-03-19)
Microglia, the immune cells of the central nervous system, constantly survey the parenchyma in the healthy brain to maintain homeostasis. When a disturbance, such as cell death, results in ATP release in vivo, microglial processes respond by utilizing P2Y12 purinergic
Yasin B Seven et al.
The Journal of physiology, 596(8), 1501-1512 (2018-02-02)
Although adenosine 2A (A2A ) receptor activation triggers specific cell signalling cascades, the ensuing physiological outcomes depend on the specific cell type expressing these receptors. Cervical spinal adenosine 2A (A2A ) receptor activation elicits a prolonged facilitation in phrenic nerve
Gemma Navarro et al.
BMC biology, 16(1), 24-24 (2018-03-01)
G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers (A1-A2AHet), and their activation leads to canonical G-protein-dependent (adenylate cyclase mediated) and -independent (β-arrestin
Simone Pelassa et al.
International journal of molecular sciences, 20(10) (2019-05-22)
Our previous findings indicate that A2A and D2 receptors are co-expressed on adult rat striatal astrocytes and on the astrocyte processes, and that A2A-D2 receptor⁻receptor interaction can control the release of glutamate from the processes. Functional evidence suggests that the
Pierre Trifilieff et al.
BioTechniques, 51(2), 111-118 (2011-08-03)
The existence of G protein-coupled receptor (GPCR) dimers and/or oligomers has been demonstrated in heterologous systems using a variety of biochemical and biophysical assays. While these interactions are the subject of intense research because of their potential role in modulating
Gemma Navarro et al.
Nature communications, 9(1), 1242-1242 (2018-03-30)
G protein-coupled receptors (GPCRs), G proteins and adenylyl cyclase (AC) comprise one of the most studied transmembrane cell signaling pathways. However, it is unknown whether the ligand-dependent interactions between these signaling molecules are based on random collisions or the rearrangement
Marco Matos et al.
Glia, 60(5), 702-716 (2012-02-03)
Glutamate is the primary excitatory neurotransmitter in the central nervous system, where its toxic build-up leads to synaptic dysfunction and excitotoxic cell death that underlies many neurodegenerative diseases. Therefore, efforts have been made to understand the regulation of glutamate transporters
Adenosine A2A receptor in the monkey basal ganglia: Ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum.
James W Bogenpohl,Stefanie L Ritter,Randy A Hall,Yoland Smith
The Journal of Comparative Neurology null
V L Batalha et al.
Molecular psychiatry, 18(3), 320-331 (2012-03-01)
Maternal separation (MS) is an early life stress model that induces permanent changes in the central nervous system, impairing hippocampal long-term potentiation (LTP) and spatial working memory. There are compelling evidences for a role of hippocampal adenosine A(2A) receptors in
Stefka Gyoneva et al.
Neuroscience, 330, 410-420 (2016-06-12)
Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by the presence of extracellular plaques composed of amyloid β (Aβ) peptides and intracellular tau aggregates. The plaques are surrounded by microglia, the brain's resident immune
Xinli Xu et al.
Scientific reports, 12(1), 14690-14690 (2022-08-30)
The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber (MF) sprouting found in diseases such as temporal lobe epilepsy. The molecular determinants underlying this retrograde
Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis.
Oliveira, L; Correia, A; Cristina Costa, A; Guerra-Gomes, S; Ferreirinha et al.
Mediators of Inflammation null
M Koshiba et al.
Molecular pharmacology, 55(3), 614-624 (1999-03-03)
Signaling through A2A adenosine receptors (A2AR) regulates T lymphocyte expansion and modulates T cell receptor (TCR)-mediated effector functions in vitro. To understand the role of A2ARs in the regulation of immune response, we investigated the expression levels of this receptor
Dasiel O Borroto-Escuela et al.
International journal of molecular sciences, 20(23) (2019-12-11)
It was previously demonstrated that rat adenosine A2AR transmembrane V peptide administration into the nucleus accumbens enhances cocaine self-administration through disruption of the A2AR-dopamine (D2R) heteroreceptor complex of this region. Unlike human A2AR transmembrane 4 (TM4) and 5 (TM5), A2AR
Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.
Coelho, JE; Alves, P; Canas, PM; Valadas, JS; Shmidt, T; Batalha, VL; Ferreira et al.
Frontiers in Psychiatry null
Jordi Bonaventura et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), E3609-E3618 (2015-06-24)
Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the A2AR-D2R heteromer, by which
Neus Garcia et al.
The European journal of neuroscience, 38(2), 2229-2241 (2013-04-24)
Immunocytochemistry shows that purinergic receptors (P1Rs) type A1 and A2A (A1 R and A2 A R, respectively) are present in the nerve endings at the P6 and P30 Levator auris longus (LAL) mouse neuromuscular junctions (NMJs). As described elsewhere, 25
Linya Wang et al.
PloS one, 19(6), e0301223-e0301223 (2024-06-05)
New immune checkpoints are emerging in a bid to improve response rates to immunotherapeutic drugs. The adenosine A2A receptor (A2AR) has been proposed as a target for immunotherapeutic development due to its participation in immunosuppression of the tumor microenvironment. Blockade
Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum.
Hettinger, B D, et al.
The Journal of Comparative Neurology, 431, 331-346 (2001)
Anna G Orr et al.
Nature neuroscience, 18(3), 423-434 (2015-01-27)
Astrocytes express a variety of G protein-coupled receptors and might influence cognitive functions, such as learning and memory. However, the roles of astrocytic Gs-coupled receptors in cognitive function are not known. We found that humans with Alzheimer's disease (AD) had
Anna G Orr et al.
Neurobiology of disease, 110, 29-36 (2017-11-05)
Adenosine A2A receptors are putative therapeutic targets for neurological disorders. The adenosine A2A receptor antagonist istradefylline is approved in Japan for Parkinson's disease and is being tested in clinical trials for this condition elsewhere. A2A receptors on neurons and astrocytes
Ying Zhu et al.
Current protocols in neuroscience, 91(1), e86-e86 (2020-01-17)
Combining immunological and molecular biological methods, the antibody-based proximity ligation assay (PLA) has been used for more than a decade to detect and quantify protein-protein interactions, protein modification, and protein expression in situ, including in brain tissue. However, the transfer
Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids.
Carriba, P; Ortiz, O; Patkar, K; Justinova, Z; Stroik, J; Themann, A; Muller, C; Woods et al.
Neuropsychopharmacology null
Jing Lu et al.
PloS one, 11(11), e0166415-e0166415 (2016-11-12)
γ-secretase mediates the intramembranous proteolysis of amyloid precursor protein (APP) and determines the generation of Aβ which is associated with Alzheimer's disease (AD). Here we identified that an anti-Parkinson's disease drug, Istradefylline, could enhance Aβ generation in various cell lines
Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system
Rosin, D. L., et al
The Journal of Comparative Neurology, 401, 163-186 (1998)
Ella E Bauer et al.
Neural plasticity, 2020, 5859098-5859098 (2020-05-14)
Adenosine acts as a key regulator of striatum activity, in part, through the antagonistic modulation of dopamine activity. Exercise can increase adenosine activity in the brain, which may impair dopaminergic functions in the striatum. Therefore, long-term repeated bouts of exercise
Alejandro Lillo et al.
Biomedicines, 10(2) (2022-02-26)
Adenosine (Ado) receptors have been instrumental in the detection of heteromers and other higher-order receptor structures, mainly via interactions with other cell surface G-protein-coupled receptors. Apart from the first report of the A1 Ado receptor interacting with the A2A Ado
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