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Kaushala Jayawardana et al.
International journal of cancer, 136(4), 863-874 (2014-07-01)
In patients with metastatic melanoma, the identification and validation of accurate prognostic biomarkers will assist rational treatment planning. Studies based on "-omics" technologies have focussed on a single high-throughput data type such as gene or microRNA transcripts. Occasionally, these features
Martijn van der Heijden et al.
Cancers, 11(4) (2019-04-28)
Hypoxic head and neck tumors respond poorly to radiotherapy and can be identified using gene expression profiles. However, it is unknown whether treatment outcome is driven by acute or chronic hypoxia. Gene expression data of 398 head and neck cancers
Gabriella Fabian et al.
International journal of molecular sciences, 12(9), 6116-6134 (2011-10-22)
Toxicogenomics, based on the temporal effects of drugs on gene expression, is able to predict toxic effects earlier than traditional technologies by analyzing changes in genomic biomarkers that could precede subsequent protein translation and initiation of histological organ damage. In
Alexandra Kalmár et al.
BMC cancer, 19(1), 1059-1059 (2019-11-07)
Long non-coding RNAs (lncRNAs) play a fundamental role in colorectal cancer (CRC) development, however, lncRNA expression profiles in CRC and its precancerous stages remain to be explored. We aimed to study whole genomic lncRNA expression patterns in colorectal adenoma-carcinoma transition
Fereshtesadat Fakhredini et al.
Cell journal, 24(1), 28-35 (2022-02-20)
One of the severe complications and well-known sources of end stage renal disease (ESRD) from diabetes mellitus is diabetic nephropathy (DN). Exosomes secreted from diverse cells are one of the novel encouraging therapies for chronic renal injuries. In this study
Abhijit Basu et al.
Scientific reports, 8(1), 6205-6205 (2018-04-20)
We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly
Weili Yang et al.
BMC genomics, 22(1), 861-861 (2021-12-01)
To explore the long non-coding RNA (lncRNA) expression pattern of congenital lung malformations on a genome-wide scale and investigate their potential biological function in four subtypes of congenital lung malformations. We obtained both lesions and normal lung control tissues from
Nóra Faragó et al.
Lipids in health and disease, 10, 173-173 (2011-10-04)
Polyunsaturated fatty acids (PUFAs) such as γ-linolenic acid (GLA), arachidonic acid (AA) and docosahexaenoic acid (DHA) have cytotoxic action on glioma cells. We evaluated the cytotoxic action of GLA, AA and DHA on glioma cells with specific reference to the
Zsolt Czimmerer et al.
PloS one, 8(1), e55168-e55168 (2013-02-06)
Short regulatory RNA-s have been identified as key regulators of gene expression in eukaryotes. They have been involved in the regulation of both physiological and pathological processes such as embryonal development, immunoregulation and cancer. One of their relevant characteristics is
Yong-Mei Zhang et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(7), G606-G613 (2014-02-08)
Acute Helicobacter pylori infection of gastric epithelial cells induces CagA oncoprotein- and peptidoglycan (SLT)-dependent mobilization of NF-κB p50 homodimers that bind to H-K-ATPase α-subunit (HKα) promoter and repress HKα gene transcription. This process may facilitate gastric H. pylori colonization by
Yoshinari Ando et al.
Molecular cell, 73(4), 845-856 (2019-02-05)
ADP-ribosylation refers to the addition of one or more ADP-ribose groups onto proteins. The attached ADP-ribose monomers or polymers, commonly known as poly(ADP-ribose) (PAR), modulate the activities of the modified substrates or their binding affinities to other proteins. However, progress in
Eva Orosz et al.
Cancer genomics & proteomics, 14(4), 285-292 (2017-06-26)
The role of microRNAs (miRNA) in carcinogenesis is related to their genome-regulatory function. The aim of the present study was to identify and compare miRNA expression signatures of meso- and hypopharynx squamous cell cancers in consideration of the cancer field
Takahito Ohshiro et al.
Scientific reports, 11(1), 19304-19304 (2021-10-01)
Epitranscriptomics is the study of RNA base modifications involving functionally relevant changes to the transcriptome. In recent years, epitranscriptomics has been an active area of research. However, a major issue has been the development of sequencing methods to map transcriptome-wide
Leah Morenos et al.
PloS one, 7(8), e42951-e42951 (2012-08-23)
Like formalin fixed paraffin embedded (FFPE) tissues, archived bone marrow aspirate slides are an abundant and untapped resource of biospecimens that could enable retrospective molecular studies of disease. Historically, RNA obtained from slides is limited in utility because of their
Zsófia Brigitta Nagy et al.
Clinical epigenetics, 9, 22-22 (2017-03-16)
MiRNA expression markers are well characterized in colorectal cancer (CRC), but less is known about miRNA expression profiles in colorectal adenomas. Genome-wide miRNA and mRNA expression analyses were conducted through the colorectal adenoma dysplasia sequence. Furthermore, analysis of the expression
Kanako Masumoto et al.
Scientific reports, 12(1), 10351-10351 (2022-06-22)
The clinical usage of induced pluripotent stem cell (iPSC)-derived regenerative medicine products is limited by the possibility of residual undifferentiated cells forming tumours after transplantation. Most of the existing quality control tests involve crushing of cells. As a result, the
Anush Martirosyan et al.
Experimental and therapeutic medicine, 12(2), 1189-1195 (2016-07-23)
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis and recurrent fetal loss, with the persistent presence of antiphospholipid antibodies (aPLs). aPLs exert their pathogenic effect via the overproduction of tissue factor and activation of complement and several
Monique C de Jong et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(24), 5630-5638 (2015-08-13)
Predominant causes of head and neck cancer recurrence after radiotherapy are rapid repopulation, hypoxia, fraction of cancer stem cells, and intrinsic radioresistance. Currently, intrinsic radioresistance can only be assessed by ex vivo colony assays. Besides being time-consuming, colony assays do
Nóra Faragó et al.
Acta biologica Hungarica, 62(4), 413-425 (2011-11-29)
Micro RNAs (miRNA) are an abundant class of small RNAs that regulate the stability and translation of cognate mRNAs. MiRNAs are potential diagnostic markers, moreover, they play an essential role in the development of various heart disesases. In case of
Yuhei Chadani et al.
Molecular cell, 68(3), 528-539 (2017-11-04)
Nascent polypeptides can modulate the polypeptide elongation speed on the ribosome. Here, we show that nascent chains can even destabilize the translating Escherichia coli ribosome from within. This phenomenon, termed intrinsic ribosome destabilization (IRD), occurs in response to a special
Vehbi Ercolak et al.
Acta haematologica, 134(4), 199-207 (2015-06-06)
Although Hodgkin's lymphoma (HL) is one of the most curable cancers in adult patients, new targets have to be defined in cases resistant to traditional chemotherapy. The preferentially expressed antigen of melanoma (PRAME) is a cancer testis antigen and its
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