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Lawrence Baruch
Postgraduate medicine, 125(2), 135-145 (2013-07-03)
Novel oral anticoagulants, direct thrombin inhibitors, and factor Xa inhibitors are being introduced into clinical practice. In contrast to vitamin K antagonists, such as warfarin, these novel agents, because of their relatively wide therapeutic range and predictable pharmacokinetics, have been
Hans F N Kvitvang et al.
Analytical chemistry, 83(7), 2705-2711 (2011-03-11)
Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few internal standards representing all metabolites, the ultimate requirement for a quantitative description of
Su Emmanuelle Degirmenci et al.
La Revue du praticien, 63(7), 976-979 (2013-10-31)
The new direct oral anticoagulants currently available are dabigatran, rivaroxaban and apixaban. These three drugs have been labeled in France for the prevention of venous thromboembolism after elective orthopaedic surgery including total hip or knee arthroplastly. Rivaroxaban is also labeled
ACP Journal Club. Review: Dabigatran does not differ from vitamin K antagonists for mortality or major bleeding.
Alex Gallus
Annals of internal medicine, 160(8), JC5-JC5 (2014-04-16)
Julie Y Culbertson et al.
Nutrients, 2(1), 75-98 (2010-01-01)
Muscle carnosine has been reported to serve as a physiological buffer, possess antioxidant properties, influence enzyme regulation, and affect sarcoplasmic reticulum calcium regulation. Beta-alanine (β-ALA) is a non-essential amino acid. β-ALA supplementation (e.g., 2-6 grams/day) has been shown to increase
Robert G Hart et al.
The Canadian journal of cardiology, 29(7 Suppl), S71-S78 (2013-06-29)
Chronic kidney disease (CKD) is prevalent in elderly patients with atrial fibrillation and is an independent risk factor for stroke. Warfarin anticoagulation is efficacious for stroke prevention in atrial fibrillation patients with moderate CKD (stage III, estimated glomerular filtration rate
I M Karmanskiĭ
Voprosy meditsinskoi khimii, 23(4), 530-534 (1977-07-01)
Native lipoproteins of low density from human blood serum were intensively hydrolyzed by pepsin in 0.1 M solution of beta-alanine-HCl at pH 1.9. About 50% and 90% of all the protein part of the substances were split off within 60
H T Benzon et al.
British journal of anaesthesia, 111 Suppl 1, i96-113 (2013-12-18)
The new oral anticoagulants are approved for a variety of clinical syndromes, including the prevention of stroke in atrial fibrillation, acute coronary syndromes, treatment of venous thromboembolism (VTE), and prevention of venous thrombosis after total joint surgery or hip fracture.
M R Johnson et al.
Biochemical pharmacology, 40(6), 1241-1246 (1990-09-15)
Our laboratory has demonstrated recently that conjugates of 2-fluoro-beta-alanine (FBAL) and bile acids are the major biliary metabolites of 5-fluorouracil (FUra) in cancer patients. Bile acids are normally conjugated with glycine or taurine, and therefore the identification of the FBAL-bile
A case of post varicella cortical venous thrombosis successfully treated with dabigatran.
Thomas Mathew et al.
Neurology India, 61(5), 531-532 (2013-11-23)
Jay R Hoffman et al.
Current sports medicine reports, 11(4), 189-195 (2012-07-11)
β-Alanine is rapidly developing as one of the most popular sport supplements used by strength/power athletes worldwide. The popularity of β-alanine stems from its unique ability to enhance intramuscular buffering capacity and thereby attenuating fatigue. This review will provide an
Eiji Shigetomi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 10143-10153 (2013-06-14)
Astrocytes are found throughout the brain where they make extensive contacts with neurons and synapses. Astrocytes are known to display intracellular Ca(2+) signals and release signaling molecules such as D-serine into the extracellular space. However, the role(s) of astrocyte Ca(2+)
Extended anticoagulation in venous thromboembolism.
Andrew J Franck et al.
The New England journal of medicine, 368(24), 2328-2329 (2013-06-14)
Ajay Yadlapati et al.
The American journal of cardiology, 113(8), 1362-1363 (2014-03-01)
Direct-current cardioversion (DCCV) for persistent atrial fibrillation or atrial flutter (AF) carries a risk of thromboembolic events (TEs). Therapeutic anticoagulation with warfarin is recommended for 3 to 4 weeks before and 4 weeks after DCCV to reduce TE; however, the
Extended anticoagulation in venous thromboembolism.
Sam Schulman
The New England journal of medicine, 368(24), 2329-2329 (2013-06-14)
[Venous thromboembolism. Currently it is worthwhile to use anticoagulants longer].
Dirk Einecke
MMW Fortschritte der Medizin, 155(6), 26-27 (2013-05-25)
[Beta-alanine aminotransferases on pyrimidine catabolism].
N Tamaki et al.
Seikagaku. The Journal of Japanese Biochemical Society, 73(9), 1151-1154 (2001-10-26)
Partha Sardar et al.
The American journal of cardiology, 113(7), 1173-1177 (2014-02-12)
Dabigatran is a novel oral anticoagulant and may be useful during atrial fibrillation (AF) ablation for prevention of thromboembolic events. However, the benefits and adverse effects of periprocedural dabigatran therapy have not been thoroughly evaluated. A meta-analysis was performed to
Activated prothrombin complex concentrate for the prevention of dabigatran-associated bleeding.
Henna Wong et al.
British journal of haematology, 166(1), 152-153 (2014-03-13)
T. Hine
Electrophoresis ?83, 541-541 null
Plasma dabigatran activity one week after discontinuation despite normal renal function.
Jecko Thachil et al.
The American journal of medicine, 126(8), e5-e6 (2013-06-27)
The importance of postapproval data for dabigatran.
Rita F Redberg
JAMA internal medicine, 175(1), 25-25 (2014-11-05)
Sandra Milasta et al.
Molecular pharmacology, 69(2), 479-491 (2005-11-12)
When expressed via an inducible promoter in human embryonic kidney 293 cells, the rat Mas-related gene D (rMrgD) receptor responded to beta-alanine but not L-alanine by elevating intracellular [Ca(2+)], stimulating phosphorylation of the mitogenactivated protein kinases known as extracellular signal-regulated
Digitalis use in contemporary clinical practice: refitting the foxglove.
Zachary D Goldberger et al.
JAMA internal medicine, 174(1), 151-154 (2013-11-13)
André B P Van Kuilenburg et al.
The Biochemical journal, 379(Pt 1), 119-124 (2004-01-07)
DPD (dihydropyrimidine dehydrogenase) constitutes the first step of the pyrimidine degradation pathway, in which the pyrimidine bases uracil and thymine are catabolized to beta-alanine and the R-enantiomer of beta-AIB (beta-aminoisobutyric acid) respectively. The S-enantiomer of beta-AIB is predominantly derived from
Prescrire international, 22(139), 155-159 (2013-07-20)
Dabigatran, rivaroxaban and apixaban are oral anticoagulants used to prevent or treat thrombosis in a variety of situations. Like all anticoagulants, these drugs can provoke bleeding. How should patients be managed if bleeding occurs during dabigatran, rivaroxaban or apixaban therapy?
Dorothea Baumann et al.
Deutsche medizinische Wochenschrift (1946), 139(30), 1539-1539 (2014-07-30)
A 90-year-old female patient treated with dabigatran for atrial fibrillation presented emergently with a spontaneous vaginal bleeding due to endometrium carcinoma. Laboratory analysis revealed azotemia consistent with acute-on-chronic renal failure. Coagulation was deranged (prolongation of activated partial thromboplastin time (aPTT)
Dabigatran in patients with mechanical heart valves.
Alexander Speirs et al.
The New England journal of medicine, 370(4), 382-382 (2014-01-24)
S Sumi et al.
Journal of chromatography. B, Biomedical applications, 672(2), 233-239 (1995-10-20)
An automated screening system for purine and pyrimidine metabolism disorders using high-performance liquid chromatography (HPLC) with column switching is described. The system consists of a reversed-phase column, a cation-exchange column, a column switch, four sets of ultraviolet absorbance detectors, a
Dabigatran in patients with mechanical heart valves.
John W Eikelboom et al.
The New England journal of medicine, 370(4), 383-384 (2014-01-24)
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