CN
Search Within
05160
应用筛选条件
关键词:'05160'
显示 1-30 共 125 条结果 关于 "05160" 范围 论文
Robert Gosselin et al.
American journal of clinical pathology, 141(2), 262-267 (2014-01-18)
To study dabigatran etexilate, a new oral anticoagulant that functions as a direct thrombin inhibitor. This study evaluates four methods, one of which is performed in three different laboratories, and compares results against dabigatran levels measured by Boehringer-Ingelheim (Ingelheim, Germany)
S Sumi et al.
Journal of chromatography. B, Biomedical applications, 672(2), 233-239 (1995-10-20)
An automated screening system for purine and pyrimidine metabolism disorders using high-performance liquid chromatography (HPLC) with column switching is described. The system consists of a reversed-phase column, a cation-exchange column, a column switch, four sets of ultraviolet absorbance detectors, a
Jay Shavadia et al.
The Canadian journal of cardiology, 29(11), 1531-1531 (2013-09-12)
The novel oral anticoagulant agents provide compelling evidence-based advance over warfarin therapy in nonvalvular atrial fibrillation and have received endorsement from contemporary guidelines. This case illustrates the challenge that clinicians will have to manage patients taking these agents who present
An updated review of target-specific oral anticoagulants used in stroke prevention in atrial fibrillation, venous thromboembolic disease, and acute coronary syndromes.
Christina L Cove et al.
Journal of the American Heart Association, 2(5), e000136-e000136 (2013-10-25)
M C Malet-Martino et al.
Drug metabolism and disposition: the biological fate of chemicals, 16(1), 78-84 (1988-01-01)
The human biliary excretion of antineoplastic fluoropyrimidines was studied using 19F NMR. This method allows a direct detection of all the fluorinated metabolites of a fluorinated drug and requires no labeled compound. From a patient with an external bile derivation
Dabigatran in patients with mechanical heart valves.
John W Eikelboom et al.
The New England journal of medicine, 370(4), 383-384 (2014-01-24)
Dabigatran in patients with mechanical heart valves.
Piero Stratta et al.
The New England journal of medicine, 370(4), 381-381 (2014-01-24)
Partha Sardar et al.
The Canadian journal of cardiology, 30(8), 888-897 (2014-07-30)
Recent reports suggest altered antithrombotic efficacy and higher risk of bleeding with new oral anticoagulants (NOACs) in patients with renal insufficiency. A meta-analysis was performed to evaluate the efficacy and safety with recommended doses of NOAC compared with conventional treatment
J U Hibbard et al.
Pediatric research, 27(1), 80-84 (1990-01-01)
Taurine, required by the fetus for nutrition and neurological development, is inadequately synthesized by the fetus and substantial quantities of the amino acid are supplied by the mother. Maternal to fetal unidirectional taurine transport was studied in in vitro perfused
Torben Bjerregaard Larsen et al.
The American journal of medicine, 127(12), 1172-1178 (2014-09-07)
This register-based observational study compares dabigatran to warfarin for secondary stroke prevention in atrial fibrillation patients among both "new starters" on dabigatran and "switchers" to dabigatran from warfarin. We identified, in nationwide Danish registries, 2398 patients with atrial fibrillation and
L O Melkonian et al.
Prikladnaia biokhimiia i mikrobiologiia, 49(2), 144-148 (2013-06-26)
The mechanisms of L-alanine overproduction by Brevibacterium flavum producer strains were studied. It was shown that beta-CI-L-alanine is an inhibitor of some key enzymes involved in the synthesis of L-alanine, including alanine transaminase and valine-pyruvate transaminase. Two highly active B.
[Bleeding complications under oral anticoagulation].
J Beyer-Westendorf
Deutsche medizinische Wochenschrift (1946), 139(49), 2491-2493 (2014-11-08)
Dabigatran pharmacokinetics--implications for treatment.
Hannes Neuwirt et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 62(1), 180-180 (2013-06-19)
Treatment of atrial fibrillation.
The Medical letter on drugs and therapeutics, 56(1446), 53-58 (2014-07-22)
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Ammar Majeed et al.
Circulation, 128(21), 2325-2332 (2013-10-02)
The aim of this study was to compare the management and prognosis of major bleeding in patients treated with dabigatran or warfarin. Two independent investigators reviewed bleeding reports from 1034 individuals with 1121 major bleeds enrolled in 5 phase III
Guilherme Giannini Artioli et al.
Medicine and science in sports and exercise, 42(6), 1162-1173 (2010-05-19)
In this narrative review, we present and discuss the current knowledge available on carnosine and beta-alanine metabolism as well as the effects of beta-alanine supplementation on exercise performance. Intramuscular acidosis has been attributed to be one of the main causes
Estella M Davis et al.
Hospital practice (1995), 42(5), 108-125 (2014-12-09)
The direct thrombin inhibitor dabigatran and factor Xa inhibitors rivaroxaban and apixaban are US Food and Drug Administration (FDA)-approved target-specific oral anticoagulants (TSOACs) that have emerged onto the market for use in some indications similar to those for warfarin; in
Jecko Thachil
Clinical medicine (London, England), 14(2), 165-175 (2014-04-10)
Anticoagulation therapy is one of the most important advances in modern medicine, saving thousands of lives from the complications of atrial fibrillation and mechanical heart valves and preventing recurrent venous thromboembolism. Warfarin and heparins have been the predominant anticoagulants used
Li Feng et al.
Oncotarget, 6(36), 39151-39164 (2015-10-17)
MicroRNAs (miRNAs) regulate disease-relevant metabolic pathways. However, most current pathway identification methods fail to consider miRNAs in addition to genes when analyzing pathways. We developed a powerful method called Subpathway-GMir to construct miRNA-regulated metabolic pathways and to identify miRNA-mediated subpathways
Torben Bjerregaard Larsen et al.
The American journal of medicine, 127(7), 650-656 (2014-02-18)
The bleeding risk among patients with atrial fibrillation is higher early after initiating therapy with vitamin K antagonists (VKAs). Evidence is limited on how prior VKA experience affects bleeding risk when initiating novel oral anticoagulant therapy. We investigated this among
B Holm et al.
Thrombosis research, 37(1), 165-176 (1985-01-01)
Fibrinogen was purified from fresh citrated human plasma by precipitation with beta-alanine in the presence of citrate and protease inhibitors. From this material, fractions corresponding to the HMW (high molecular weight), LMW and LMW' fibrinogen fractions of plasma were obtained
M R Johnson et al.
Biochemical pharmacology, 40(6), 1241-1246 (1990-09-15)
Our laboratory has demonstrated recently that conjugates of 2-fluoro-beta-alanine (FBAL) and bile acids are the major biliary metabolites of 5-fluorouracil (FUra) in cancer patients. Bile acids are normally conjugated with glycine or taurine, and therefore the identification of the FBAL-bile
A case of post varicella cortical venous thrombosis successfully treated with dabigatran.
Thomas Mathew et al.
Neurology India, 61(5), 531-532 (2013-11-23)
Jay R Hoffman et al.
Current sports medicine reports, 11(4), 189-195 (2012-07-11)
β-Alanine is rapidly developing as one of the most popular sport supplements used by strength/power athletes worldwide. The popularity of β-alanine stems from its unique ability to enhance intramuscular buffering capacity and thereby attenuating fatigue. This review will provide an
Eiji Shigetomi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 10143-10153 (2013-06-14)
Astrocytes are found throughout the brain where they make extensive contacts with neurons and synapses. Astrocytes are known to display intracellular Ca(2+) signals and release signaling molecules such as D-serine into the extracellular space. However, the role(s) of astrocyte Ca(2+)
K E Tiedje et al.
Neurochemistry international, 57(3), 177-188 (2010-06-15)
This review discusses the role of beta-alanine as a neurotransmitter. Beta-alanine is structurally intermediate between alpha-amino acid (glycine, glutamate) and gamma-amino acid (GABA) neurotransmitters. In general, beta-alanine satisfies a number of the prerequisite classical criteria for being a neurotransmitter: beta-alanine
Doug Coyle et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 16(4), 498-506 (2013-06-26)
The primary objective was to assess the cost-effectiveness of new oral anticoagulants compared with warfarin in patients with nonvalvular atrial fibrillation. Secondary objectives related to assessing the cost-effectiveness of new oral anticoagulants stratified by center-specific time in therapeutic range, age
Response to letters regarding article, “Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Randomized Trial”.
Jeff S Healey et al.
Circulation, 127(11), e506-e506 (2013-05-07)
Extended anticoagulation in venous thromboembolism.
Andrew J Franck et al.
The New England journal of medicine, 368(24), 2328-2329 (2013-06-14)
1/5