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05160
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Dabigatran, ROCKET atrial fibrillation, and beyond: basic science, mechanisms of agents, monitoring, and reversal.
Kenneth A Bauer
Stroke, 44(6 Suppl 1), S38-S40 (2013-06-05)
Plasma dabigatran activity one week after discontinuation despite normal renal function.
Jecko Thachil et al.
The American journal of medicine, 126(8), e5-e6 (2013-06-27)
Partha Sardar et al.
The American journal of cardiology, 113(7), 1173-1177 (2014-02-12)
Dabigatran is a novel oral anticoagulant and may be useful during atrial fibrillation (AF) ablation for prevention of thromboembolic events. However, the benefits and adverse effects of periprocedural dabigatran therapy have not been thoroughly evaluated. A meta-analysis was performed to
Activated prothrombin complex concentrate for the prevention of dabigatran-associated bleeding.
Henna Wong et al.
British journal of haematology, 166(1), 152-153 (2014-03-13)
Jan Heyland et al.
Microbial biotechnology, 3(1), 74-83 (2011-01-25)
β-Peptides and their derivates are usually stable to proteolysis and have an increased half-life compared with α-peptides. Recently, β-aminopeptidases were described as a new enzyme class that enabled the enzymatic degradation and formation of β-peptides. As an alternative to the
Jiro Arima et al.
Journal of biotechnology, 147(1), 52-58 (2010-03-23)
Synthesis of beta-alanine (beta-Ala) containing dipeptide using S9 aminopeptidase from Streptomyces thermocyaneoviolaceus NBRC14271 (S9AP-St) was demonstrated with beta-Ala-benzyl ester (-OBzl) and various L-aminoacyl derivatives. For synthesis of beta-Ala-containing dipeptide, beta-Ala-OBzl was used preferentially as the acyl donor for S9AP-St, producing
The importance of postapproval data for dabigatran.
Rita F Redberg
JAMA internal medicine, 175(1), 25-25 (2014-11-05)
[Beta-alanine aminotransferases on pyrimidine catabolism].
N Tamaki et al.
Seikagaku. The Journal of Japanese Biochemical Society, 73(9), 1151-1154 (2001-10-26)
Prescrire international, 22(139), 155-159 (2013-07-20)
Dabigatran, rivaroxaban and apixaban are oral anticoagulants used to prevent or treat thrombosis in a variety of situations. Like all anticoagulants, these drugs can provoke bleeding. How should patients be managed if bleeding occurs during dabigatran, rivaroxaban or apixaban therapy?
Roger C Harris et al.
Medicine and sport science, 59, 1-17 (2012-10-19)
Glycolysis involves the oxidation of two neutral hydroxyl groups on each glycosyl (or glucosyl) unit metabolised, yielding two carboxylic acid groups. During low-intensity exercise these, along with the remainder of the carbon skeleton, are further oxidised to CO(2) and water.
Sandra Milasta et al.
Molecular pharmacology, 69(2), 479-491 (2005-11-12)
When expressed via an inducible promoter in human embryonic kidney 293 cells, the rat Mas-related gene D (rMrgD) receptor responded to beta-alanine but not L-alanine by elevating intracellular [Ca(2+)], stimulating phosphorylation of the mitogenactivated protein kinases known as extracellular signal-regulated
Dorothea Baumann et al.
Deutsche medizinische Wochenschrift (1946), 139(30), 1539-1539 (2014-07-30)
A 90-year-old female patient treated with dabigatran for atrial fibrillation presented emergently with a spontaneous vaginal bleeding due to endometrium carcinoma. Laboratory analysis revealed azotemia consistent with acute-on-chronic renal failure. Coagulation was deranged (prolongation of activated partial thromboplastin time (aPTT)
K E Tiedje et al.
Neurochemistry international, 57(3), 177-188 (2010-06-15)
This review discusses the role of beta-alanine as a neurotransmitter. Beta-alanine is structurally intermediate between alpha-amino acid (glycine, glutamate) and gamma-amino acid (GABA) neurotransmitters. In general, beta-alanine satisfies a number of the prerequisite classical criteria for being a neurotransmitter: beta-alanine
K M Gibson et al.
Journal of neurochemistry, 81(1), 71-79 (2002-06-18)
Metabolite profiling in succinate semialdehyde dehydrogenase (SSADH; Aldh5a1-/-) deficient mice previously revealed elevated gamma-hydroxybutyrate (GHB) and total GABA in urine and total brain and liver extracts. In this study, we extend our metabolic characterization of these mutant mice by documenting
Ajay Yadlapati et al.
The American journal of cardiology, 113(8), 1362-1363 (2014-03-01)
Direct-current cardioversion (DCCV) for persistent atrial fibrillation or atrial flutter (AF) carries a risk of thromboembolic events (TEs). Therapeutic anticoagulation with warfarin is recommended for 3 to 4 weeks before and 4 weeks after DCCV to reduce TE; however, the
[Venous thromboembolism. Currently it is worthwhile to use anticoagulants longer].
Dirk Einecke
MMW Fortschritte der Medizin, 155(6), 26-27 (2013-05-25)
Extended anticoagulation in venous thromboembolism.
Andrew J Franck et al.
The New England journal of medicine, 368(24), 2328-2329 (2013-06-14)
Lawrence Baruch
Postgraduate medicine, 125(2), 135-145 (2013-07-03)
Novel oral anticoagulants, direct thrombin inhibitors, and factor Xa inhibitors are being introduced into clinical practice. In contrast to vitamin K antagonists, such as warfarin, these novel agents, because of their relatively wide therapeutic range and predictable pharmacokinetics, have been
Extended anticoagulation in venous thromboembolism.
Sam Schulman
The New England journal of medicine, 368(24), 2329-2329 (2013-06-14)
Benjamin A Steinberg et al.
BMJ (Clinical research ed.), 348, g2116-g2116 (2014-04-16)
Atrial fibrillation increases the risk of stroke, which is a leading cause of death and disability worldwide. The use of oral anticoagulation in patients with atrial fibrillation at moderate or high risk of stroke, estimated by established criteria, improves outcomes.
Dabigatran in patients with mechanical heart valves.
Alexander Speirs et al.
The New England journal of medicine, 370(4), 382-382 (2014-01-24)
André B P Van Kuilenburg et al.
The Biochemical journal, 379(Pt 1), 119-124 (2004-01-07)
DPD (dihydropyrimidine dehydrogenase) constitutes the first step of the pyrimidine degradation pathway, in which the pyrimidine bases uracil and thymine are catabolized to beta-alanine and the R-enantiomer of beta-AIB (beta-aminoisobutyric acid) respectively. The S-enantiomer of beta-AIB is predominantly derived from
Digitalis use in contemporary clinical practice: refitting the foxglove.
Zachary D Goldberger et al.
JAMA internal medicine, 174(1), 151-154 (2013-11-13)
A case of post varicella cortical venous thrombosis successfully treated with dabigatran.
Thomas Mathew et al.
Neurology India, 61(5), 531-532 (2013-11-23)
Jay R Hoffman et al.
Current sports medicine reports, 11(4), 189-195 (2012-07-11)
β-Alanine is rapidly developing as one of the most popular sport supplements used by strength/power athletes worldwide. The popularity of β-alanine stems from its unique ability to enhance intramuscular buffering capacity and thereby attenuating fatigue. This review will provide an
Eiji Shigetomi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 10143-10153 (2013-06-14)
Astrocytes are found throughout the brain where they make extensive contacts with neurons and synapses. Astrocytes are known to display intracellular Ca(2+) signals and release signaling molecules such as D-serine into the extracellular space. However, the role(s) of astrocyte Ca(2+)
Hans F N Kvitvang et al.
Analytical chemistry, 83(7), 2705-2711 (2011-03-11)
Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few internal standards representing all metabolites, the ultimate requirement for a quantitative description of
ACP Journal Club. Review: Dabigatran does not differ from vitamin K antagonists for mortality or major bleeding.
Alex Gallus
Annals of internal medicine, 160(8), JC5-JC5 (2014-04-16)
Julie Y Culbertson et al.
Nutrients, 2(1), 75-98 (2010-01-01)
Muscle carnosine has been reported to serve as a physiological buffer, possess antioxidant properties, influence enzyme regulation, and affect sarcoplasmic reticulum calcium regulation. Beta-alanine (β-ALA) is a non-essential amino acid. β-ALA supplementation (e.g., 2-6 grams/day) has been shown to increase
Su Emmanuelle Degirmenci et al.
La Revue du praticien, 63(7), 976-979 (2013-10-31)
The new direct oral anticoagulants currently available are dabigatran, rivaroxaban and apixaban. These three drugs have been labeled in France for the prevention of venous thromboembolism after elective orthopaedic surgery including total hip or knee arthroplastly. Rivaroxaban is also labeled
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