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显示 31-60 共 125 条结果 关于 "05160" 范围 论文
Eiji Shigetomi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 10143-10153 (2013-06-14)
Astrocytes are found throughout the brain where they make extensive contacts with neurons and synapses. Astrocytes are known to display intracellular Ca(2+) signals and release signaling molecules such as D-serine into the extracellular space. However, the role(s) of astrocyte Ca(2+)
Robert G Hart et al.
The Canadian journal of cardiology, 29(7 Suppl), S71-S78 (2013-06-29)
Chronic kidney disease (CKD) is prevalent in elderly patients with atrial fibrillation and is an independent risk factor for stroke. Warfarin anticoagulation is efficacious for stroke prevention in atrial fibrillation patients with moderate CKD (stage III, estimated glomerular filtration rate
I M Karmanskiĭ
Voprosy meditsinskoi khimii, 23(4), 530-534 (1977-07-01)
Native lipoproteins of low density from human blood serum were intensively hydrolyzed by pepsin in 0.1 M solution of beta-alanine-HCl at pH 1.9. About 50% and 90% of all the protein part of the substances were split off within 60
Julie Y Culbertson et al.
Nutrients, 2(1), 75-98 (2010-01-01)
Muscle carnosine has been reported to serve as a physiological buffer, possess antioxidant properties, influence enzyme regulation, and affect sarcoplasmic reticulum calcium regulation. Beta-alanine (β-ALA) is a non-essential amino acid. β-ALA supplementation (e.g., 2-6 grams/day) has been shown to increase
ACP Journal Club. Review: Dabigatran does not differ from vitamin K antagonists for mortality or major bleeding.
Alex Gallus
Annals of internal medicine, 160(8), JC5-JC5 (2014-04-16)
Hans F N Kvitvang et al.
Analytical chemistry, 83(7), 2705-2711 (2011-03-11)
Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few internal standards representing all metabolites, the ultimate requirement for a quantitative description of
Su Emmanuelle Degirmenci et al.
La Revue du praticien, 63(7), 976-979 (2013-10-31)
The new direct oral anticoagulants currently available are dabigatran, rivaroxaban and apixaban. These three drugs have been labeled in France for the prevention of venous thromboembolism after elective orthopaedic surgery including total hip or knee arthroplastly. Rivaroxaban is also labeled
H T Benzon et al.
British journal of anaesthesia, 111 Suppl 1, i96-113 (2013-12-18)
The new oral anticoagulants are approved for a variety of clinical syndromes, including the prevention of stroke in atrial fibrillation, acute coronary syndromes, treatment of venous thromboembolism (VTE), and prevention of venous thrombosis after total joint surgery or hip fracture.
Jay Shavadia et al.
The Canadian journal of cardiology, 29(11), 1531-1531 (2013-09-12)
The novel oral anticoagulant agents provide compelling evidence-based advance over warfarin therapy in nonvalvular atrial fibrillation and have received endorsement from contemporary guidelines. This case illustrates the challenge that clinicians will have to manage patients taking these agents who present
Li Feng et al.
Oncotarget, 6(36), 39151-39164 (2015-10-17)
MicroRNAs (miRNAs) regulate disease-relevant metabolic pathways. However, most current pathway identification methods fail to consider miRNAs in addition to genes when analyzing pathways. We developed a powerful method called Subpathway-GMir to construct miRNA-regulated metabolic pathways and to identify miRNA-mediated subpathways
B Holm et al.
Thrombosis research, 37(1), 165-176 (1985-01-01)
Fibrinogen was purified from fresh citrated human plasma by precipitation with beta-alanine in the presence of citrate and protease inhibitors. From this material, fractions corresponding to the HMW (high molecular weight), LMW and LMW' fibrinogen fractions of plasma were obtained
Estella M Davis et al.
Hospital practice (1995), 42(5), 108-125 (2014-12-09)
The direct thrombin inhibitor dabigatran and factor Xa inhibitors rivaroxaban and apixaban are US Food and Drug Administration (FDA)-approved target-specific oral anticoagulants (TSOACs) that have emerged onto the market for use in some indications similar to those for warfarin; in
Ammar Majeed et al.
Circulation, 128(21), 2325-2332 (2013-10-02)
The aim of this study was to compare the management and prognosis of major bleeding in patients treated with dabigatran or warfarin. Two independent investigators reviewed bleeding reports from 1034 individuals with 1121 major bleeds enrolled in 5 phase III
Torben Bjerregaard Larsen et al.
The American journal of medicine, 127(7), 650-656 (2014-02-18)
The bleeding risk among patients with atrial fibrillation is higher early after initiating therapy with vitamin K antagonists (VKAs). Evidence is limited on how prior VKA experience affects bleeding risk when initiating novel oral anticoagulant therapy. We investigated this among
S Sumi et al.
Journal of chromatography. B, Biomedical applications, 672(2), 233-239 (1995-10-20)
An automated screening system for purine and pyrimidine metabolism disorders using high-performance liquid chromatography (HPLC) with column switching is described. The system consists of a reversed-phase column, a cation-exchange column, a column switch, four sets of ultraviolet absorbance detectors, a
Treatment of atrial fibrillation.
The Medical letter on drugs and therapeutics, 56(1446), 53-58 (2014-07-22)
M C Malet-Martino et al.
Drug metabolism and disposition: the biological fate of chemicals, 16(1), 78-84 (1988-01-01)
The human biliary excretion of antineoplastic fluoropyrimidines was studied using 19F NMR. This method allows a direct detection of all the fluorinated metabolites of a fluorinated drug and requires no labeled compound. From a patient with an external bile derivation
An updated review of target-specific oral anticoagulants used in stroke prevention in atrial fibrillation, venous thromboembolic disease, and acute coronary syndromes.
Christina L Cove et al.
Journal of the American Heart Association, 2(5), e000136-e000136 (2013-10-25)
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Guilherme Giannini Artioli et al.
Medicine and science in sports and exercise, 42(6), 1162-1173 (2010-05-19)
In this narrative review, we present and discuss the current knowledge available on carnosine and beta-alanine metabolism as well as the effects of beta-alanine supplementation on exercise performance. Intramuscular acidosis has been attributed to be one of the main causes
Jecko Thachil
Clinical medicine (London, England), 14(2), 165-175 (2014-04-10)
Anticoagulation therapy is one of the most important advances in modern medicine, saving thousands of lives from the complications of atrial fibrillation and mechanical heart valves and preventing recurrent venous thromboembolism. Warfarin and heparins have been the predominant anticoagulants used
Partha Sardar et al.
The Canadian journal of cardiology, 30(8), 888-897 (2014-07-30)
Recent reports suggest altered antithrombotic efficacy and higher risk of bleeding with new oral anticoagulants (NOACs) in patients with renal insufficiency. A meta-analysis was performed to evaluate the efficacy and safety with recommended doses of NOAC compared with conventional treatment
J U Hibbard et al.
Pediatric research, 27(1), 80-84 (1990-01-01)
Taurine, required by the fetus for nutrition and neurological development, is inadequately synthesized by the fetus and substantial quantities of the amino acid are supplied by the mother. Maternal to fetal unidirectional taurine transport was studied in in vitro perfused
Dabigatran in patients with mechanical heart valves.
John W Eikelboom et al.
The New England journal of medicine, 370(4), 383-384 (2014-01-24)
Dabigatran in patients with mechanical heart valves.
Piero Stratta et al.
The New England journal of medicine, 370(4), 381-381 (2014-01-24)
L O Melkonian et al.
Prikladnaia biokhimiia i mikrobiologiia, 49(2), 144-148 (2013-06-26)
The mechanisms of L-alanine overproduction by Brevibacterium flavum producer strains were studied. It was shown that beta-CI-L-alanine is an inhibitor of some key enzymes involved in the synthesis of L-alanine, including alanine transaminase and valine-pyruvate transaminase. Two highly active B.
Robert Gosselin et al.
American journal of clinical pathology, 141(2), 262-267 (2014-01-18)
To study dabigatran etexilate, a new oral anticoagulant that functions as a direct thrombin inhibitor. This study evaluates four methods, one of which is performed in three different laboratories, and compares results against dabigatran levels measured by Boehringer-Ingelheim (Ingelheim, Germany)
[Bleeding complications under oral anticoagulation].
J Beyer-Westendorf
Deutsche medizinische Wochenschrift (1946), 139(49), 2491-2493 (2014-11-08)
Anna K Kopec et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 288-297 (2014-08-21)
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome. Robust coagulation cascade activation is common in obese patients with NAFLD. We identified a critical temporal relationship between thrombin generation and the manifestation of hepatic steatosis
Torben Bjerregaard Larsen et al.
The American journal of medicine, 127(12), 1172-1178 (2014-09-07)
This register-based observational study compares dabigatran to warfarin for secondary stroke prevention in atrial fibrillation patients among both "new starters" on dabigatran and "switchers" to dabigatran from warfarin. We identified, in nationwide Danish registries, 2398 patients with atrial fibrillation and
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