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Rao Mukkavilli et al.
PloS one, 9(9), e108386-e108386 (2014-09-25)
Natural and complementary therapies in conjunction with mainstream cancer care are steadily gaining popularity. Ginger extract (GE) confers significant health-promoting benefits owing to complex additive and/or synergistic interactions between its bioactive constituents. Recently, we showed that preservation of natural "milieu"
J Bluett et al.
The Analyst, 140(6), 1981-1987 (2015-02-12)
Rheumatoid arthritis (RA) is a common autoimmune disease that causes significant disability and reduced life expectancy. The folate antagonist methotrexate (MTX) is first-line therapy for RA when used weekly at low doses (5-25 mg). However, the true rate of adherence
Hyung-seung Kim et al.
Archives of pharmacal research, 37(10), 1317-1324 (2014-07-24)
A method of simultaneously screening 215 types of pesticides has been established by liquid chromatography with tandem mass spectrometry, quadrupole/time of flight mass spectrometry and triple quadrupole mass spectrometry. Samples of blood and gastric contents were prepared through the modified
Thomas Mercier et al.
Journal of chromatography. A, 1369, 52-63 (2014-12-03)
Colistin is a last resort's antibacterial treatment in critically ill patients with multi-drug resistant Gram-negative infections. As appropriate colistin exposure is the key for maximizing efficacy while minimizing toxicity, individualized dosing optimization guided by therapeutic drug monitoring is a top
Patricia Regal et al.
Journal of agricultural and food chemistry, 63(1), 370-378 (2014-12-09)
The endogenous occurrence of natural hormones obstructs the application of classical targeted methods as confirmatory options. In the case of estradiol, the ultimate confirmation of its exogenous administration relies on gas chromatography coupled to combustion/isotope ratio mass spectrometry (GC-C/IRMS). A
Yan Xiong et al.
Proteomics, 14(15), 1808-1819 (2014-05-21)
Parkinson's disease (PD) is characterized as a movement disorder due to lesions in the basal ganglia. As the major input region of the basal ganglia, striatum plays a vital role in coordinating movements. It receives afferents from the cerebral cortex
Guangguo Tan et al.
Journal of pharmaceutical and biomedical analysis, 96, 187-196 (2014-04-25)
Xenobiotic metabolome identificatioqn of Chinese herbal prescription in biological systems is a very challenging task. In the present work, a reliable strategy based on the combination of ultra-performance liquid chromatography-electrospray ionization quadrupole-time-of-flight mass spectrometry (UHPLC-ESI-Q-TOFMS) and pattern recognition approach such
Zhipeng Wang et al.
Scientific reports, 5, 9301-9301 (2015-03-31)
Chemoresistance is a poor prognostic factor in breast cancer and is a major obstacle to the successful treatment of patients receiving chemotherapy. However, the precise mechanism of resistance remains unclear. In this study, a pair of breast cancer cell lines
Ruth Alonso et al.
Journal of Alzheimer's disease : JAD, 41(1), 301-311 (2014-03-13)
Alzheimer's disease is a progressive neurodegenerative disorder that leads to dementia mainly among the elderly. This disease is characterized by the presence in the brain of amyloid plaques and neurofibrillary tangles that provoke neuronal cell death, vascular dysfunction, and inflammatory
Sihyung Yang et al.
Antimicrobial agents and chemotherapy, 58(7), 4064-4074 (2014-05-07)
Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system [CNS]) infection.
Anne-Claire Groo et al.
Pharmaceutical research, 31(7), 1753-1765 (2014-01-29)
To study, diffusion through mucus (3D model) of different formulations of paclitaxel loaded lipid nanocapsules (Ptx-LNCs), to interpret the results in the light of LNC behavior at air-mucus interface (2D model). LNC surface properties were modified with chitosan or poly(ethylene
Nathaniel H Thayer et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(39), 14019-14026 (2014-09-18)
Long-lived proteins have been implicated in age-associated decline in metazoa, but they have only been identified in extracellular matrices or postmitotic cells. However, the aging process also occurs in dividing cells undergoing repeated asymmetric divisions. It was not clear whether
Holly D Cox et al.
Drug testing and analysis, 7(1), 31-38 (2014-09-12)
AOD9604 is a peptide consisting of the C-terminal fragment of human growth hormone from amino acids 177-191 with an additional tyrosine residue at the N-terminus of the peptide. It is reported to mimic the lipolytic properties of growth hormone without
Teresa L Parsons et al.
Journal of pharmaceutical and biomedical analysis, 98, 407-416 (2014-07-10)
Topical microbicidal agents are being actively pursued as a modality to prevent HIV viral transmission during sexual intercourse. Quantification of antiretroviral agents in specimen sources where antiviral activity is elicited is critical, and drug measurements in cervicovaginal fluid can provide
Dae J Park et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 147-152 (2014-06-14)
New tandem mass spectrometric method coupled with liquid chromatography (LC-MS/MS) has been developed to determine the total concentration of camptothecin derivatives (irinotecan and SN-38) regardless of inter-conversion phenomenon between carboxylate and lactone forms. At first, all sample solutions were acidified
Liqing Wu et al.
Analytical and bioanalytical chemistry, 407(11), 3125-3135 (2014-12-24)
This article concerns the development and co-validation of a porcine insulin (pINS) certified reference material (CRM) produced by the National Institute of Metrology, People's Republic of China. Each CRM unit contained about 15 mg of purified solid pINS. The moisture content
María del Mar Ramírez Fernández et al.
Journal of analytical toxicology, 38(5), 280-288 (2014-05-03)
The aim of this work was to automate a sample preparation procedure extracting morphine, hydromorphone, oxymorphone, norcodeine, codeine, dihydrocodeine, oxycodone, 6-monoacetyl-morphine, hydrocodone, ethylmorphine, benzoylecgonine, cocaine, cocaethylene, tramadol, meperidine, pentazocine, fentanyl, norfentanyl, buprenorphine, norbuprenorphine, propoxyphene, methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine from urine samples.
T-Y Kao et al.
Cell death & disease, 6, e1642-e1642 (2015-02-13)
Human Lon protease is a mitochondrial matrix protein with several functions, including protein degradation, mitochondrial DNA (mtDNA) binding, and chaperone activity. Lon is currently emerging as an important regulator of mitochondria-contributed tumorigenesis due to its overexpression in cancer cells. To
Chang-Ning Liu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 116-125 (2014-10-19)
Crizotinib (Xalkori) is a tyrosine kinase inhibitor of both anaplastic lymphoma kinase (ALK) and mesenchymal-epithelial transition factor (c-Met). Though not predicted from standard nonclinical toxicological evaluation, visual disturbance became a frequently observed adverse event in humans. To understand the possible
Chandré M Willemse et al.
Journal of chromatography. A, 1359, 189-201 (2014-08-13)
Anthocyanins are naturally occurring plant pigments whose accurate analysis is hampered by their complexity and unique chromatographic behaviour associated with on-column conversion reactions. This paper reports the evaluation of off-line comprehensive two-dimensional liquid chromatography (LC×LC) for the analysis of anthocyanins.
Zhenzhen Huang et al.
Journal of pharmaceutical and biomedical analysis, 100, 175-183 (2014-08-30)
Serum peptidomic approach was applied to investigate the peptidomic signature and discover the clinical biomarkers and biomarker patterns for RCC patients. The holistic orthogonal partial least-squares-discriminant analysis (OPLS-DA) based on qualified profile data successfully classified RCC patients from healthy controls
Steven Pham et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt B, 436-444 (2014-09-10)
Castration resistant prostate cancer (CRPC) is often lethal and inevitably develops after androgen ablation therapy. However, in the majority of cases it remains androgen dependent. CRPC tumors have the ability to synthesize their own androgens from cholesterol by engaging in
Kate L Lee et al.
Endocrinology, 156(3), 1194-1199 (2014-12-30)
The search for an islet β-cell growth factor has been a key objective in recent diabetes research, because the ability to regenerate and/or protect the functioning β-cell population in patients could result in a great advancement for diabetes treatment. IGF-I
Linlin Zhao et al.
Evidence-based complementary and alternative medicine : eCAM, 2014, 385102-385102 (2014-08-21)
A metabonomics approach based on liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) was utilized to obtain potential biomarkers of coronary heart disease (CHD) patients and investigate the ZHENG types differentiation in CHD patients. The plasma samples of 20 CHD patients with
Quantitative proteomic profiling reveals differentially regulated proteins in cystic fibrosis cells.
Navin Rauniyar et al.
Journal of proteome research, 13(11), 4668-4675 (2014-05-14)
The most prevalent cause of cystic fibrosis (CF) is the deletion of a phenylalanine residue at position 508 in CFTR (ΔF508-CFTR) protein. The mutated protein fails to fold properly, is retained in the endoplasmic reticulum via the action of molecular
Ning-fang Cai et al.
Acta pharmacologica Sinica, 35(11), 1447-1452 (2014-10-07)
Pharmacodynamic analysis of intravenous recombinant urate oxidase produced by Escherichia coli was performed in healthy subjects using a pharmacokinetic/pharmacodynamic (PK/PD) model. A randomized, single-blind, placebo-controlled study was performed in 40 healthy Chinese subjects (4 groups of 10 subjects each, placebo
Jun Jiang et al.
Drug testing and analysis, 7(4), 309-319 (2014-06-18)
The isomers, although of similarly chemical structures, have different pharmacological activities due to their metabolic processes in vivo. Central-icaritin (c-IT) and icaritin (IT) are isomers and major bioactive aglycones of the Herba Epimedii. In this study, we found that the
Lizhen Qiao et al.
Journal of chromatography. A, 1360, 240-247 (2014-08-19)
Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-d-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. In
Yetrib Hathout et al.
Human molecular genetics, 23(24), 6458-6469 (2014-07-17)
It is expected that serum protein biomarkers in Duchenne muscular dystrophy (DMD) will reflect disease pathogenesis, progression and aid future therapy developments. Here, we describe use of quantitative in vivo stable isotope labeling in mammals to accurately compare serum proteomes
Maribel Reyes et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 139-149 (2014-09-05)
1. Ponesimod [(R)-5-[3-chloro-4-(-2,3-dihydroxy-propoxy)-benzylidene]-2-propylimino-3-o-tolyl-thiazolidin-4-one] is an orally administered, selective S1P1 receptor modulator that blocks the egress of lymphocytes from lymphoid organs and reduces the availability of circulating effector T/B-cells. 2. The mass balance, pharmacokinetics and metabolism of 40 mg (14)C-ponesimod were investigated in six
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