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Chunbo Yang et al.
Nature communications, 11(1), 3812-3812 (2020-08-01)
Vascular endothelial cell (EC) dysfunction plays a key role in diabetic complications. This study discovers significant upregulation of Quaking-7 (QKI-7) in iPS cell-derived ECs when exposed to hyperglycemia, and in human iPS-ECs from diabetic patients. QKI-7 is also highly expressed
Karim A Sarhane et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 16(4), 1283-1295 (2019-05-31)
Functional recovery following nerve injury declines when target re-innervation is delayed. Currently, no intervention exists to improve outcomes after prolonged denervation. We explored the neuroregenerative effects of glial cell line-derived neurotrophic factor (GDNF) and chondroitinase (CDN) in a chronic denervation
Cole D Libner et al.
The Journal of comparative neurology, 528(10), 1704-1724 (2019-12-25)
Neurodegeneration, including loss of neurons and axons, is a feature of progressive forms of multiple sclerosis (MS). The mechanisms underlying neurodegeneration are mostly unknown. Research implicates autoimmunity to nonmyelin self-antigens as important contributors to disease pathogenesis. Data from our lab
Seyeon Oh et al.
Scientific reports, 11(1), 2012-2012 (2021-01-23)
Despite the advancement of targeted therapy for pulmonary arterial hypertension (PAH), poor prognosis remains a reality. Mesenchymal stem cells (MSCs) are one of the most clinically feasible alternative treatment options. We compared the treatment effects of adipose tissue (AD)-, bone
A L Franklin et al.
Stain technology, 60(3), 125-135 (1985-05-01)
The antioxidant beta-mercaptoethanol (BME) used in conjunction with the permanent mountant DPX (DPX-BME) retarded fluorescent fading of mithramycin, acridine orange and Hoechst 33258 stained chicken erythrocytes, each to a varying degree. The initial fluorescence of all dyes examined was more
Taide Wang et al.
Cell death and differentiation, 27(5), 1728-1739 (2019-11-21)
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is proposed to occur by necroptosis, an inflammatory form of regulated cell death. Prior studies implicated necroptosis in ALS based on accumulation of necroptotic markers in affected tissues of patients and mouse
The level and distribution pattern of HP1beta in the embryonic brain correspond to those of H3K9me1/me2 but not of H3K9me3
Bartova E, et al.
Histochemistry and Cell Biology, 145(4), 447-461 (2016)
Yoshihisa Okuchi et al.
Nature materials, 20(1), 108-118 (2020-09-23)
The maintenance of human skeletal stem cells (hSSCs) and their progeny in bone defects is a major challenge. Here, we report on a transplantable bandage containing a three-dimensional Wnt-induced osteogenic tissue model (WIOTM). This bandage facilitates the long-term viability of
Hyesook Yoon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(7), 1483-1500 (2020-01-09)
Myelin loss limits neurological recovery and myelin regeneration and is critical for restoration of function. We recently discovered that global knock-out of the thrombin receptor, also known as Protease Activated Receptor 1 (PAR1), accelerates myelin development. Here we demonstrate that
Eleni Maniati et al.
Cell reports, 30(2), 525-540 (2020-01-16)
Although there are many prospective targets in the tumor microenvironment (TME) of high-grade serous ovarian cancer (HGSOC), pre-clinical testing is challenging, especially as there is limited information on the murine TME. Here, we characterize the TME of six orthotopic, transplantable syngeneic
Developmental neurotoxicity after penconazole exposure at embryo pre- and post-implantation in mice.
Abd El-Fattah M El-Shershaby et al.
Journal of histotechnology, 43(3), 135-146 (2020-05-20)
The present study was conducted to evaluate the effect of penconazole fungicide at a low dose (2.5 mg/kg b.w.) during embryogenesis in either the pre- or post-implantation of embryos. Females were determined pregnant according to the presence of vaginal plug
Irene Anastasia et al.
Cell reports, 34(11), 108873-108873 (2021-03-18)
Contacts between organelles create microdomains that play major roles in regulating key intracellular activities and signaling pathways, but whether they also regulate systemic functions remains unknown. Here, we report the ultrastructural organization and dynamics of the inter-organellar contact established by
Baixuan He et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(10), 13361-13375 (2020-08-28)
Radiotherapy is one of the most effective treatments for head and neck tumors. However, delayed radiation-induced brain necrosis (RN) remains a serious issue due to the lack of satisfying prevention and effective treatment. The pathological role of radiation in the
Paola Sanches Cella et al.
Nutrition (Burbank, Los Angeles County, Calif.), 79-80, 110958-110958 (2020-09-04)
This study aimed to analyze the effect of creatine (Cr) supplementation on tumor microenvironment, evaluating the parameters of tumor aggressiveness. Sixteen male Wistar rats were randomly assigned to 2 groups (n = 8/group): Tumor-bearing (T) and tumor-bearing supplemented with Cr (TCr). Cr
Degang Wu et al.
Experimental neurology, 332, 113386-113386 (2020-06-27)
Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining
Ewa Guzniczak et al.
Biotechnology and bioengineering, 117(7), 2032-2045 (2020-02-27)
Cell-based therapeutics, such as in vitro manufactured red blood cells (mRBCs), are different to traditional biopharmaceutical products (the final product being the cells themselves as opposed to biological molecules such as proteins) and that presents a challenge of developing new
Erin M Triplet et al.
Neurobiology of disease, 152, 105294-105294 (2021-02-08)
Despite concerted efforts to identify CNS regeneration strategies, an incomplete understanding of how the needed molecular machinery is regulated limits progress. Here we use models of lateral compression and FEJOTA clip contusion-compression spinal cord injury (SCI) to identify the thrombin
Roberta Parolisi et al.
Brain structure & function, 222(6), 2625-2639 (2017-02-27)
Adult neurogenesis has been implicated in brain plasticity and brain repair. In mammals, it is mostly restricted to specific brain regions and specific physiological functions. The function and evolutionary history of mammalian adult neurogenesis has been elusive so far. The
Lucía Barbier-Torres et al.
Nature communications, 11(1), 3360-3360 (2020-07-06)
Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD remains a major unmet need. Here, we identify MCJ (Methylation-Controlled J protein) as a
Tao Zhang et al.
PloS one, 15(10), e0239601-e0239601 (2020-10-29)
APC mutations drive human colorectal cancer (CRC) development. A major contributing factor is colonic stem cell (SC) overpopulation. But, the mechanism has not been fully identified. A possible mechanism is the dysregulation of neuroendocrine cell (NEC) maturation by APC mutations
Da Jung Jung et al.
Biofabrication, 12(4), 045035-045035 (2020-10-02)
A biologically relevant in vitro model of hepatic microtissue would be a valuable tool for the preclinical study of pharmacokinetics and metabolism. Although considerable advances have been made in recent years in the establishment of alternative in vitro culture systems
Ayman M Ibrahim et al.
International journal of molecular sciences, 21(19) (2020-10-03)
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart muscle disease, with a prevalence of at least 1 in 500 in the general population. The disease is pleiotropic and is characterized by an increased stiffness of the myocardium, partly due
Sebastiaan Dalle et al.
Journal of muscle research and cell motility, 41(4), 375-387 (2020-07-06)
To improve muscle healing upon injury, it is of importance to understand the interplay of key signaling pathways during muscle regeneration. To study this, mice were injected with cardiotoxin (CTX) or PBS in the Tibialis Anterior muscle and were sacrificed
Ane Murueta-Goyena et al.
Molecular neurobiology, 57(1), 125-134 (2019-09-12)
Dysregulation of the inhibitory drive has been proposed to be a central mechanism to explain symptoms and pathophysiological hallmarks in schizophrenia. A number of recent neuroanatomical studies suggest that certain types of inhibitory cells are deficient in schizophrenia, including somatostatin-immunoreactive
Alberto Smargiassi et al.
Molecular and cellular endocrinology, 513, 110817-110817 (2020-05-23)
The Osteocyte, recognized as a major orchestrator of osteoblast and osteoclast activity, is the most important key player during bone remodeling processes. Imbalances occurring during bone remodeling, caused by hormone perturbations or by mechanical loading alterations, can induce bone pathologies
Altered Brain Leptin and Leptin Receptor Expression in the 5XFAD Mouse Model of Alzheimer's Disease.
Anishchal A Pratap et al.
Pharmaceuticals (Basel, Switzerland), 13(11) (2020-11-22)
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the accumulation of amyloid plaques and neurofibrillary tangles. Interestingly, individuals with metabolic syndromes share some pathologies with those diagnosed with AD including neuroinflammation, insulin resistance and cognitive deficits. Leptin, an
Motomasa Tanioka et al.
International journal of molecular sciences, 21(8) (2020-04-17)
Lipid emulsion was recently shown to attenuate cell death caused by excitotoxic conditions in the heart. There are key similarities between neurons and cardiomyocytes, such as excitability and conductibility, which yield vulnerability to excitotoxic conditions. However, systematic investigations on the
Karīna Narbute et al.
Cellular and molecular neurobiology, 41(3), 605-613 (2020-05-16)
We have recently demonstrated that extracellular vesicles (EVs) derived from the human teeth stem cells improve motor symptoms and normalize tyrosine hydroxylase (TH) expression in the nigrostriatal structures of Parkinson's disease (PD) model rats obtained by 6-hydroxydopamine (6-OHDA) unilateral injection
Impaired central respiratory chemoreflex in an experimental genetic model of epilepsy.
Totola LT
The Journal of Physiology, 595 (2017)
Christopher H Dillingham et al.
The Journal of comparative neurology, 525(17), 3742-3756 (2017-08-09)
The complex neuroanatomical connections of the inferior colliculus (IC) and its major subdivisions offer a juxtaposition of segregated processing streams with distinct organizational features. While the tonotopically layered central nucleus is well-documented, less is known about functional compartments in the
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