07-189

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关键词:'07-189'

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NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling.

Susana López-López et al.

Frontiers in immunology, 12, 734966-734966 (2021-12-21)

NOTCH4 is a member of the NOTCH family of receptors whose expression is intensively induced in macrophages after their activation by Toll-like receptors (TLR) and/or interferon-γ (IFN-γ). In this work, we show that this receptor acts as a negative regulator

Notch4 normalization reduces blood vessel size in arteriovenous malformations.

Murphy, PA; Kim, TN; Lu, G; Bollen, AW; Schaffer, CB; Wang, RA

Science Translational Medicine null

Original Research: Featured Article: Imatinib mesylate (Gleevec) inhibits Notch and c-Myc signaling: Five-day treatment permanently rescues mammary development.

Robert Callahan et al.

Experimental biology and medicine (Maywood, N.J.), 242(1), 53-67 (2016-08-24)

Wap-Int3 transgenic females expressing the Notch4 intracellular domain (designated Int3) from the whey acidic protein promoter exhibit two phenotypes in the mammary gland: blockage of lobuloalveolar development and lactation, and tumor development with 100% penetrance. Previously, we have shown that

Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.

S Zhang et al.

Oncogene, 35(19), 2485-2495 (2015-08-19)

Notch controls pancreatic differentiation during development and is reactivated in pancreatic cancer. In recent years, the importance of Notch signaling in pancreatic tumorigenesis has become increasingly evident; however, it remains unclear how Notch activities are regulated in this context. Here

TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma.

Jingwei Wan et al.

Frontiers in pharmacology, 11, 590723-590723 (2021-01-01)

We have reported that transient receptor potential melastatin-related 7 (TRPM7) regulates glioma stem cells (GSC) growth and proliferation through Notch, STAT3-ALDH1, and CD133 signaling pathways. In this study, we determined the major contributor(s) to TRPM7 mediated glioma stemness by further

Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation.

Wu, J; Bresnick, EH

Molecular and cellular biology null

The pattern of expression of Notch protein members in normal and pathological endometrium.

Luigi Cobellis et al.

Journal of anatomy, 213(4), 464-472 (2008-08-12)

The objective of this study was to investigate the pattern of expression and the localization of Notch-1, Notch-4 and Jagged-1 in physiological and pathological human endometrium and to evaluate the expression levels of two major regulators of the G1 checkpoint

Cripto-1 as a novel therapeutic target for triple negative breast cancer.

Nadia P Castro et al.

Oncotarget, 6(14), 11910-11929 (2015-06-11)

Triple-negative breast cancer (TNBC) presents the poorest prognosis among the breast cancer subtypes and no current standard therapy. Here, we performed an in-depth molecular analysis of a mouse model that establishes spontaneous lung metastasis from JygMC(A) cells. These primary tumors

Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.

Sharon Bargo,Ahmed Raafat,David McCurdy,Idean Amirjazil,Youmin Shu,June Traicoff et al.

Biochemical and biophysical research communications null

The ANK repeats of Notch-4/Int3 activate NF-κB canonical pathway in the absence of Rbpj and causes mammary tumorigenesis.

Ahmed Raafat et al.

Scientific reports, 7(1), 13690-13690 (2017-10-24)

Transgenic mice expressing the Notch-4 intracellular domain (designated Int3) in the mammary gland have two phenotypes exhibited with 100% penetrance: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch-4 signaling is mediated primarily through the interaction of Int3 with the

Regulation of gliomagenesis and stemness through acid sensor ASIC1a.

Pendelton King et al.

International journal of oncology, 59(4) (2021-09-14)

Glioblastoma multiforme (GBM) is the most prevalent and aggressive type of adult gliomas. Despite intensive therapy including surgery, radiation, and chemotherapy, invariable tumor recurrence occurs, which suggests that glioblastoma stem cells (GSCs) render these tumors persistent. Recently, the induction of

JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin.

Karmveer Singh et al.

Nature communications, 9(1), 3425-3425 (2018-08-26)

Transcription factors ensure skin homeostasis via tight regulation of distinct resident stem cells. Here we report that JunB, a member of the AP-1 transcription factor family, regulates epidermal stem cells and sebaceous glands through balancing proliferation and differentiation of progenitors

Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland.

Ahmed Raafat et al.

Journal of cellular physiology, 226(7), 1940-1952 (2011-04-21)

Notch genes play a critical role in mammary gland growth, development and tumorigenesis. In the present study, we have quantitatively determined the levels and mRNA expression patterns of the Notch receptor genes, their ligands and target genes in the postnatal

Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer.

Magnani, L; Stoeck, A; Zhang, X; Lanczky, A; Mirabella, AC; Wang, TL; Gyorffy, B; Lupien, M

Proceedings of the National Academy of Sciences of the USA null

Elongin C is a mediator of Notch4 activity in human renal tubule cells.

Cummins, TD; Mendenhall, MD; Lowry, MN; Korte, EA; Barati, MT; Khundmiri, SJ; Salyer et al.

Biochimica et Biophysica Acta null

Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation.

Lawrence Huang et al.

Science advances, 9(21), eade7280-eade7280 (2023-05-26)

Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4*EC), we show decreased arteriolar tone in vivo during brain AVM initiation. Reduced vascular tone is a primary effect of Notch4*EC

Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.

Zhang, S; Chung, WC; Wu, G; Egan, SE; Xu, K

Neoplasia null

Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.

Wen-Cheng Chung et al.

Neoplasia (New York, N.Y.), 19(11), 885-895 (2017-09-25)

Claudin-low breast cancer (CLBC) is a poor prognosis molecular subtype showing stemness and mesenchymal features. We previously discovered that deletion of a Notch signaling modulator, Lunatic Fringe (Lfng), in the mouse mammary gland induced a subset of tumors resembling CLBC.

High-resolution HLA-DRB1 genotyping in an Australian inclusion body myositis (s-IBM) cohort: an analysis of disease-associated alleles and diplotypes.

Arada Rojana-udomsart et al.

Journal of neuroimmunology, 250(1-2), 77-82 (2012-05-29)

We performed high-resolution (4-digit) HLA-DRB1 genotyping in an Australian cohort of 105s-IBM patients and 189 controls. Our findings showed that whilst the strongest association was with the HLA-DRB1*03:01 allele and the HLA-DRB1*03:01/*01:01 diplotype, HLA-DRB1*01:01 and HLA-DRB1*13:01 are also risk alleles.

Concurrent speed endurance and resistance training improves performance, running economy, and muscle NHE1 in moderately trained runners.

Casper Skovgaard et al.

Journal of applied physiology (Bethesda, Md. : 1985), 117(10), 1097-1109 (2014-09-06)

The purpose of this study was to examine whether speed endurance training (SET, repeated 30-s sprints) and heavy resistance training (HRT, 80-90% of 1 repetition maximum) performed in succession are compatible and lead to performance improvements in moderately trained endurance

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