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Rui Wang et al.
The Journal of organic chemistry, 78(17), 8696-8704 (2013-08-27)
The hydroxyl-substituted benzoic acid (as phenyl group A in the product), aniline (as phenyl group B in the product), benzaldehyde (as phenyl group C in the product), and four isocyanides are employed to synthesize bis-amide via an Ugi four-component reaction.
Tom Craig et al.
Biotechnology and bioengineering, 110(4), 1098-1105 (2012-11-06)
Benzaldehyde, with its apricot and almond-like aroma, is the second most abundantly used molecule in the flavor industry, and is most commonly produced via chemical routes, such as by the oxidation of toluene. Biologically produced benzaldehyde, whether by extraction of
Hong Han et al.
Dalton transactions (Cambridge, England : 2003), 41(36), 11116-11124 (2012-08-07)
Five oxovanadium(IV) complexes, which were divided into two groups, [V(IV)O(bhbb, nhbb)(H(2)O)(2)] (tridentate ligands: H(2)bhbb = 2-(5-bromo-2-hydroxylbenzylideneamino)benzoic acid, 1; H(2)nhbb = 2-(5-nitro-2-hydroxylbenzylideneamino)benzoic acid, 2) and [V(IV)O(cpmp, bpmp, npmp)(2)] (bidentate ligands: Hcpmp = 4-chloro-2-((phenylimino)methyl)phenol, 3; Hbpmp = 4-bromo-2-((phenylimino)methyl)phenol, 4; Hnpmp = 4-nitro-2-((phenylimino)methyl)
Shinya Sato et al.
The Journal of biological chemistry, 288(51), 36589-36597 (2013-11-13)
Our previous study suggested the presence of a novel cone-specific redox reaction that generates 11-cis-retinal from 11-cis-retinol in the carp retina. This reaction is unique in that 1) both 11-cis-retinol and all-trans-retinal were required to produce 11-cis-retinal; 2) together with
Haiqiang Jin et al.
International journal of pharmaceutics, 434(1-2), 384-390 (2012-06-12)
To find a way to modulate the effect of thrombolytic proteins by increasing their specificity, minimizing their adverse effect as well as lengthening their circulation time for the treatment of ischemic vascular disease holds great promise. In this work, urokinase-type
Jens Schubert et al.
Archives of toxicology, 86(8), 1309-1316 (2012-06-19)
In recent years, the number of waterpipe smokers has increased substantially worldwide. Here, we present a study on the identification and quantification of seven carbonylic compounds including formaldehyde, acetaldehyde and acrolein in the mainstream smoke of the waterpipe. Smoking was
Fengniu Lu et al.
Dalton transactions (Cambridge, England : 2003), 42(34), 12093-12100 (2013-05-21)
A novel luminescent biscyclometalated iridium(III) complex [Ir(C^N)2bpy]PF6 (Ir-S, bpy = 2,2'-bipyridine) containing two 2-phenylpyridine (ppy) cyclometalating ligands (C^N) functionalized with 1,3-dithiane for the detection of Hg(2+) ions has been synthesized and characterized by spectroscopic and photophysical measurements. The luminescence of
Pingxi Xu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(46), 16592-16597 (2014-10-29)
Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbenzamide) is a 6-decade-old synthetic repellent, which is still considered the gold standard of mosquito repellents. Mosquitoes
Gabriella Fiorentino et al.
Biochimica et biophysica acta, 1844(6), 1167-1172 (2014-04-08)
The multiple antibiotic resistance regulators (MarR) constitute a family of ligand-responsive transcriptional regulators ubiquitous among the bacterial and archaeal domains. BldR, an archaeal MarR member characterized from the hyperthermophilic crenarchaeon Sulfolobus solfataricus regulates its own expression and that of an
Manabu Nakazono et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 27-34 (2014-05-13)
Various styrylbenzene compounds were synthesized and evaluated as mainly Aβ amyloid sensors. These compounds, however, cannot be used for detecting amyloid deposition in peripheral nerves because of the inherent sensitivity of the compounds. These compounds often generate false positives especially
Aditya M Kunjapur et al.
Journal of the American Chemical Society, 136(33), 11644-11654 (2014-07-31)
Aromatic aldehydes are useful in numerous applications, especially as flavors, fragrances, and pharmaceutical precursors. However, microbial synthesis of aldehydes is hindered by rapid, endogenous, and redundant conversion of aldehydes to their corresponding alcohols. We report the construction of an Escherichia
Catharine H Rankin
The Journal of experimental biology, 218(Pt 1), 41-49 (2015-01-09)
Inheritance of acquired characteristics without changes in DNA sequence has been called transgenerational epigenetics. This review looks at studies that used the model system Caenorhabditis elegans to uncover mechanisms of transgenerational epigenetics in studies of RNA interference, studies of longevity
Hong-gen Peng et al.
Chemical communications (Cambridge, England), 49(26), 2709-2711 (2013-02-26)
A center radially fibrous silica encapsulated TS-1 zeolite (TS-1@KCC-1) has been synthesized in a microemulsion system for the first time. Supporting the Rh(OH)3 species, this novel core-shell structured material serves as a robust bifunctional catalyst for one-pot synthesis of benzamide
Raz Krizevski et al.
Phytochemistry, 81, 71-79 (2012-06-26)
Ephedrine and pseudoephedrine are phenylpropylamino alkaloids widely used in modern medicine. Some Ephedra species such as E. sinica Stapf (Ephedraceae), a widely used Chinese medicinal plant (Chinese name: Ma Huang), accumulate ephedrine alkaloids as active constituents. Other Ephedra species, such
Emanuele Brai et al.
The European journal of neuroscience, 40(10), 3436-3449 (2014-09-23)
Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory bulb (OB). Odour
Ajay K Singh et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 113, 393-399 (2013-06-12)
Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non electrolytes. Elemental analyses suggest
Ihsan Ullah et al.
Journal of microbiology (Seoul, Korea), 53(2), 127-133 (2015-01-30)
The Photorhabdus temperata M1021 secretes toxic compounds that kill their insect hosts by arresting immune responses. Present study was aimed to purify the insecticidal and antimicrobial compound(s) from the culture extract of P. temperata M1021 through bioassay guided fractionation. An
Micol Maritan et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3537-3542 (2009-02-17)
A distinctive feature in the topographic organization of the olfactory system in mammals is the dual function of the odorant receptor (OR): it detects odors in the nasal epithelium and plays an instructive role in the axonal convergence of olfactory
Thermoresponsive dynamic covalent single-chain polymer nanoparticles reversibly transform into a hydrogel.
Daniel E Whitaker et al.
Angewandte Chemie (International ed. in English), 52(3), 956-959 (2012-12-12)
Silvia Maglioni et al.
Experimental gerontology, 56, 89-98 (2014-04-09)
Progressive neuronal deterioration accompanied by sensory functions decline is typically observed during aging. On the other hand, structural or functional alterations of specific sensory neurons extend lifespan in the nematode Caenorhabditis elegans. Hormesis is a phenomenon by which the body
Giulia Caron et al.
Journal of medicinal chemistry, 48(9), 3269-3279 (2005-04-29)
Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in
Daihua Hu et al.
Natural product communications, 8(3), 393-396 (2013-05-18)
Attraction of the soybean pod borer, Leguminivora glycinivorella (Matsumura), an economically important pest of soybean, to nine plant volatiles, alone or combined with two kinds of synthetic sex pheromone, ((E,E)-8,10-dodecadienyl acetate (EE8,10-12:Ac), or a blend of EE8,10-12:Ac and (E)-10-dodecenyl acetate
Paweł Mochalski et al.
Cell biochemistry and biophysics, 71(1), 323-329 (2014-08-16)
Gas chromatography with mass spectrometric detection combined with head-space needle trap extraction as the pre-concentration technique was applied to identify and quantify volatile organic compounds released or metabolised by human umbilical vein endothelial cells. Amongst the consumed species there were
Elizandra Aparecida Britta et al.
PloS one, 7(8), e41440-e41440 (2012-08-08)
Leishmaniasis is a major health problem that affects more than 12 million people. Treatment presents several problems, including high toxicity and many adverse effects, leading to the discontinuation of treatment and emergence of resistant strains. We evaluated the in vitro
Shota Kurotsu et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 79-88 (2014-04-29)
Idiopathic pulmonary fibrosis is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)-β1-induced increase in myofibroblast number plays an important role in this abnormal fibrosis.
Li Liu et al.
Bioorganic & medicinal chemistry letters, 22(1), 154-163 (2011-12-06)
The binding between the estrogen receptor α (ER-α) and a variety of compounds in traditional Chinese formulae, Si-Wu-Tang (SWT) series decoctions, was studied using a stably-transfected human breast cancer cell line (MVLN). In 38 compounds tested from SWT series decoctions
Nicholas G Spiropulos et al.
Artificial DNA, PNA & XNA, 3(3), 123-128 (2013-02-02)
Here we describe the first example of selective reductive amination in biological fluids using split aptamer proximity ligation (StAPL). Utilizing the cocaine split aptamer, we demonstrate small-molecule-dependent ligation that is dose-dependent over a wide range of target concentrations in buffer
Alan Andersen
International journal of toxicology, 25 Suppl 1, 11-27 (2006-07-13)
Benzaldehyde is an aromatic aldehyde used in cosmetics as a denaturant, a flavoring agent, and as a fragrance. Currently used in only seven cosmetic products, its highest reported concentration of use was 0.5% in perfumes. Benzaldehyde is a generally regarded
Capillary gas chromatography determination of benzaldehyde arising from benzyl alcohol used as preservative in injectable formulations.
Kazemifard AG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 31(4), 685-691 (2003)
Minna Rahnasto et al.
Journal of medicinal chemistry, 48(2), 440-449 (2005-01-22)
The purpose of this study was to develop screening and in silico modeling methods to obtain accurate information on the active center of CYP2A6, a nicotine oxidizing enzyme. The inhibitory potencies of 26 naphthalene and 16 non-naphthalene derivatives were determined
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