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Pisit Tangkijvanich et al.
Hepato-gastroenterology, 51(55), 15-19 (2004-03-12)
Cholangiocarcinoma is particularly common in Northeastern Thailand where the liver fluke, O. viverrini, is endemic. Currently there is no sensitive and specific tumor marker for the diagnosis of this cancer. The aim of this study was to investigate the accuracy
Ji-Eun Ra et al.
Food chemistry, 317, 126388-126388 (2020-02-23)
Policosanols is a health promoting aliphatic alcohol known as lipid-lowing agent. To enable maximising the functional properties of wheat, this research investigates the policosanol profiles and adenosine 5'-monophosphate-activated protein kinase (AMPK) activation potential of Korean wheat seedlings according to cultivars
Alexandra Bernardo-Colón et al.
Frontiers in physiology, 13, 1045613-1045613 (2022-12-06)
Retinal and choroidal inflammatory lesions increase the levels of the pro-inflammatory cytokine interleukin-6 (IL-6). Pigment epithelium-derived factor (PEDF) has anti-inflammatory properties, but it is not known if it can prevent the production of IL-6 by the retinal pigment epithelium. To
Tingxuan Gu et al.
Frontiers in immunology, 11, 621441-621441 (2021-02-16)
Although COVID-19 has become a major challenge to global health, there are currently no efficacious agents for effective treatment. Cytokine storm syndrome (CSS) can lead to acute respiratory distress syndrome (ARDS), which contributes to most COVID-19 mortalities. Research points to
Loïc Duron et al.
Neuroradiology, 60(1), 27-34 (2017-09-25)
The current staging system of central nervous system (CNS) germ cell tumors (GCT) includes a binary classification in "localized" or "metastatic" disease based on the absence or presence of leptomeningeal dissemination. Loco-regional tumor dissemination has been barely described whereas its
Scott J C Pallett et al.
The Lancet. Respiratory medicine, 8(9), 885-894 (2020-07-28)
Health-care workers constitute a high-risk population for acquisition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Capacity for acute diagnosis via PCR testing was limited for individuals with mild to moderate SARS-CoV-2 infection in the early phase of the
M Iwamoto et al.
Bioorganic & medicinal chemistry, 9(7), 1911-1921 (2001-06-27)
Three new labdane-type diterpenoids, labda-8(17),13-dien-15,12R-olid-19-oic acid (1), 12S-hydroxylabda-8(17),13(16),14-trien-19-oic acid (2) and 13-ethoxylabda-8(17),11,14-trien-19-oic acid (3), along with known diterpenoids, trans-communic acid (4), totarol (5), 12-methoxyabieta-8,11,13-trien-11-ol (6), and 7 alpha,8 alpha-epoxy-6 alpha-hydroxyabieta-9(11),13-dien-12-one (7) were isolated from the stem bark of Thuja standishii.
Peter V Giannoudis et al.
Clinical orthopaedics and related research, 467(12), 3239-3248 (2009-04-28)
Combining autologous bone graft and recombinant human bone morphogenetic protein-7 (BMP-7) to treat long-bone fracture aseptic atrophic nonunions theoretically could promote bone healing at higher rates than each of these grafting agents separately. We retrospectively reviewed prospectively collected data on
Selma Tobudic et al.
Vaccines, 10(7) (2022-07-28)
This prospective cohort study analyzed the immune response to COVID-19 mRNA vaccines in lung transplant recipients (LuTRs) compared to healthy controls (HCs) at a 6-month follow-up. After the first two doses of either BNT162b2 or mRNA-1273, SARS-CoV-2 antibodies were measured
Takeaki Shinzato et al.
Medical science monitor : international medical journal of experimental and clinical research, 14(9), CR431-CR437 (2008-09-02)
Resistance to EPO therapy in hemodialysis (HD) patients is ascribed to inflammation and iron deficiency. Hepcidin, an antimicrobial peptide, is a key regulator of iron metabolism and synthesis of hepcidin is regulated by iron status and inflammation. The role of
Rose A Devasia et al.
The Journal of antimicrobial chemotherapy, 63(6), 1173-1178 (2009-03-31)
The aim of this study was to assess the sensitivity, specificity and time to results of mycobacterial growth indicator tube (MGIT) 960, microscopic observation drug susceptibility (MODS) assay and nitrate reductase assay (NRA) compared with the gold standard agar proportion
P Barillari et al.
Diseases of the colon and rectum, 35(5), 471-476 (1992-05-01)
Sixty-six consecutive patients who underwent curative resection for rectal cancer were studied prospectively to evaluate the roles of sequential carcinoembryonic antigen (CEA), tissue plasminogen activator (TPA), and carcinomatous antigen 19-9 (Ca 19-9) determinations in the early diagnosis of resectable recurrences.
Michel R Nasr et al.
American journal of clinical pathology, 133(1), 41-48 (2009-12-22)
The optimal use of transcription factors to determine B-lineage specificity in B-acute lymphoblastic leukemia/lymphoma (B-ALL) has not been fully investigated. We undertook an extensive immunohistochemical study of a panel of B-cell transcription factors in B- and T-ALL and Burkitt lymphoma
Mitsuteru Numazawa et al.
Biochemistry, 44(32), 10839-10845 (2005-08-10)
Aromatase is a cytochrome P-450 enzyme complex that catalyzes the conversion of androst-4-ene-3,17-dione (AD) to estrone and formic acid through three sequential oxygenations of the 19-methyl group. To gain insight into the catalytic function of aromatase as well as the
Helén L Dichek et al.
Journal of lipid research, 45(3), 551-560 (2003-12-18)
Hepatic lipase clears plasma cholesterol by lipolytic and nonlipolytic processing of lipoproteins. We hypothesized that the nonlipolytic processing (known as the bridging function) clears cholesterol by removing apoB-48- and apoB-100-containing lipoproteins by whole particle uptake. To test our hypotheses, we
A Claing et al.
Journal of cardiovascular pharmacology, 26 Suppl 3, S72-S74 (1995-01-01)
To develop a new family of endothelin-converting enzyme (ECE) inhibitors, we assessed the inhibitory properties of an N- and C-terminal-truncated analogue of big endothelin (ET)-1[1-38], [Phe22]-big-ET-1 [19-37], on the renal vasoconstrictor properties of big ET-1 and ET-1. We had previously
Vikas K Sarna et al.
Gut, 67(9), 1606-1613 (2017-08-06)
Initiation of a gluten-free diet without proper diagnostic work-up of coeliac disease is a frequent and demanding problem. Recent diagnostic guidelines suggest a gluten challenge of at least 14 days followed by duodenal biopsy in such patients. The rate of
Zeli Zhang et al.
Cell, 185(14), 2434-2451 (2022-06-29)
Multiple COVID-19 vaccines, representing diverse vaccine platforms, successfully protect against symptomatic COVID-19 cases and deaths. Head-to-head comparisons of T cell, B cell, and antibody responses to diverse vaccines in humans are likely to be informative for understanding protective immunity against COVID-19
Rebeca Romero Aburto et al.
ACS nano, 9(7), 7009-7018 (2015-05-29)
Here we investigated the fluorination of graphene oxide nanoribbons (GONRs) using H2 and F2 gases at low temperature, below 200 °C, with the purpose of elucidating their structure and predicting a fluorination mechanism. The importance of this study is the
A A Shah et al.
Head and neck pathology, 4(2), 106-112 (2010-04-21)
This study investigated the role of human papillomavirus (HPV) in Schneiderian papillomas (SPs) to determine whether HPV is associated with the pathogenesis of particular histologic subtypes and whether p16(INK4a) can be used as a surrogate marker for HPV detection. Twenty-seven
Xiaolong Wei et al.
Journal of vascular surgery, 66(3), 850-857 (2017-06-22)
This study describes the safety and midterm efficacy of a noncovered stent-assisted embolization (SAE) technique in treating patients with wide-base renal artery aneurysms (RAAs). Between February 2011 and June 2014, 34 RAAs in 28 consecutive patients were treated with noncovered
Mohamed Tarek Moustafa et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 33(8), 610-619 (2017-09-30)
Memantine (MEM) acts on the glutamatergic system by blocking N-methyl-d-aspartate (NMDA) glutamate receptors. The role that MEM plays in protecting retinal cells is unknown. Hydroquinone (HQ) is one of the cytotoxic components in cigarette smoke. In the present study, we
Tong Zhao et al.
Journal of food protection, 74(12), 2024-2030 (2011-12-22)
Surface contamination (skin and feathers) of broilers with Salmonella occurs primarily during growth and transportation. Immediately after transporting chickens, chicken cage doors were sprayed with a foam containing 3% levulinic acid plus 2% sodium dodecyl sulfate (SDS). Samples were collected
Kyoko Nakagawa-Goto et al.
Bioorganic & medicinal chemistry letters, 19(13), 3378-3381 (2009-06-02)
C-3 esterifications of betulinic acid (BA, 1) and its A-ring homolog, ceanothic acid (CA, 2), were carried out to provide sixteen terpenoids, 4-19, including nine new compounds (4-12). All synthesized compounds were evaluated in an in vitro antitumor-promoting assay using
Yuanqi Zhu et al.
Biological chemistry, 383(6), 983-987 (2002-09-12)
N-acetyltransferase 2 (NAT2) catalyzes N-acetylation and O-acetylation of many drugs and environmental carcinogens. Genetic polymorphisms in the NAT2 gene have been associated with differential susceptibility to cancers and drug toxicity from these compounds. Single nucleotide polymorphisms (SNPs) have been identified
C Bauer et al.
Veterinary parasitology, 21(3), 189-203 (1986-08-01)
The prevalence of benzimidazole-resistant small strongyles was determined in a survey, conducted on 14 thoroughbred studs, which compared the faecal egg counts of groups of horses before and after treatment with the recommended doses of cambendazole (20 mg kg-1 b.w.)
Sing-Huang Tan et al.
Oncology reports, 18(5), 1225-1230 (2007-10-05)
The purpose was to validate the use of RUNX3 as a potential biomarker for detection of cancer in serum samples and to determine its sensitivity alone and in combination with p16, RASSF1A and CDH1 using methylation-specific polymerase chain reaction (MSP).
Tao Suo et al.
Emerging microbes & infections, 9(1), 1259-1268 (2020-05-23)
Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which results
Houmei Nakasato et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 252(6), 977-982 (2014-03-29)
To describe a new technique to perform trabeculotomy ab interno on eyes with open-angle glaucoma (OAG). This was a retrospective study. We inserted a 25-gauge forceps that is usually used for internal limiting membrane peeling into the anterior chamber, and
Torsten Bohn et al.
Food & function, 9(7), 3835-3844 (2018-06-29)
Various health benefits of carotenoids have been described. However, while human observational studies generally suggest positive health effects, supplementation with relatively high doses of individual carotenoids (supplements) have partly produced adverse effects. In the present study, we investigated the effect
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