101-41-7

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(11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas.

Eunkyung Park et al.

European journal of nuclear medicine and molecular imaging, 42(7), 1081-1092 (2015-04-03)

Activated microglia play a key role in inflammatory demyelinating injury in multiple sclerosis (MS). Microglial activation can be measured in vivo using a positron emission tomography (PET) ligand (11)C-PBR28. We evaluated the test-retest variability (TRV) and lesion detectability of (11)C-PBR28

Brain Natriuretic Peptide as the long-term cause of mortality in patients with cardiovascular disease: a retrospective cohort study.

Chunhong Zhang et al.

International journal of clinical and experimental medicine, 8(9), 16364-16368 (2015-12-03)

To explore the influence of BNP (Brain Natriuretic Peptide) in plasma on the long-term cause of mortality and prognosis of patients with cardiovascular disease (CVD). We performed a retrospective cohort study of 276 inpatients that enrolled in our hospital from

Prognosis of adenocarcinoma of the uterine cervix: p53 expression correlates with higher incidence of mortality.

Astrid Baalbergen et al.

International journal of cancer, 121(1), 106-110 (2007-03-14)

We investigated the significance of prognostic markers-estrogen receptor, progesterone receptor, p53, MIB-1 and bcl-2 - in adenocarcinoma of the uterine cervix. In 101 patients with primary cervical adenocarcinoma, treated from 1989 to 2000, we evaluated clinical parameters in relation to

Impact of pharmacogenetic markers of CYP2B6, clinical factors, and drug-drug interaction on efavirenz concentrations in HIV/tuberculosis-coinfected patients.

Weerawat Manosuthi et al.

Antimicrobial agents and chemotherapy, 57(2), 1019-1024 (2012-12-21)

Comprehensive information on the effects of cytochrome P450 2B6 (CYP2B6) polymorphisms, clinical factors, and drug-drug interactions on efavirenz concentrations in HIV/tuberculosis-coinfected (HIV/TB) patients is unavailable. A total of 139 HIV/TB adults, 101 of whom received a rifampin-containing anti-TB regimen, were

Use of the Gastrografin challenge in patients with a history of abdominal or pelvic malignancy.

Mohammad A Khasawneh et al.

Surgery, 154(4), 769-775 (2013-10-01)

The Gastrografin (GG) challenge was developed to predict the need for operative management in patients with small bowel obstruction (SBO). Although clinical trials have demonstrated that it is an effective diagnostic and therapeutic modality, these studies excluded patients with a

Converting-enzyme inhibitor administration lowers urinary free 19-nor-deoxycorticosterone levels.

G T Griffing et al.

Hypertension (Dallas, Tex. : 1979), 7(2), 178-181 (1985-03-01)

19-Nor-deoxycorticosterone (19-nor-DOC) is a human mineralocorticoid. The regulation of its secretion is poorly understood, as renin angiotensin II (ANG II) stimulation has minimal effects on 19-nor-DOC. This study sought to determine if ANG II inhibition would decrease 19-nor-DOC production. Six

A pilot study of genetic polymorphisms and hemodialysis vascular access thrombosis.

Donald F Brophy et al.

Hemodialysis international. International Symposium on Home Hemodialysis, 13(1), 19-26 (2009-02-13)

Vascular access thrombosis (VAT) remains a significant problem worldwide. This study determined the association between VAT and 7 candidate gene polymorphisms (factor V Leiden 1691G>A, factor II 20210G>A, methylenetetrahydrofolate reductase 677C>T, angiotensin converting enzyme 287 base pair (bp) insertion/deletion, transforming

Adjunctive Maintenance Lamotrigine for Pediatric Bipolar I Disorder: A Placebo-Controlled, Randomized Withdrawal Study.

Robert L Findling et al.

Journal of the American Academy of Child and Adolescent Psychiatry, 54(12), 1020-1031 (2015-11-26)

This study aimed to compare the efficacy of lamotrigine versus placebo in 10- to 17-year-olds with bipolar I disorder (BP-I) who were receiving conventional bipolar disorder treatment. In this randomized withdrawal trial, patients with BP-I of at least moderate severity

Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance.

Maria Laura Bertolaccini et al.

Thrombosis and haemostasis, 90(4), 636-641 (2003-09-30)

Antibodies directed against protein S (anti-ProtS) may be involved in the development of thrombosis in patients with the antiphospholipid syndrome. We assessed the prevalence and clinical significance of anti-ProtS and evaluated their immunological characteristics in 184 patients with SLE and

Migraine and coronary artery disease: an open study on the genetic polymorphism of the 5, 10 methylenetetrahydrofolate (MTHFR) and angiotensin I-converting enzyme (ACE) genes.

V Pizza et al.

Central nervous system agents in medicinal chemistry, 10(2), 91-96 (2010-06-04)

Genetic factors that increase susceptibility to oxidative stress, endothelial disfunction and, possibly, stroke include angiotensin-converting enzyme gene deletion polymorphism (ACE-DD) and the methylentetrahydropholate reductase (MTHFR) C677-TT polymorphism. The relationship of ACE-DD genotype to ischemic stroke and cardiovascular disease is controversial

Efficacy and safety of bexarotene combined with psoralen-ultraviolet A (PUVA) compared with PUVA treatment alone in stage IB-IIA mycosis fungoides: final results from the EORTC Cutaneous Lymphoma Task Force phase III randomized clinical trial (NCT00056056).

S Whittaker et al.

The British journal of dermatology, 167(3), 678-687 (2012-08-29)

Psoralen plus ultraviolet A (PUVA) is the standard treatment for early stages of mycosis fungoides. There have been no adequate randomized controlled trials with sufficient power comparing this modality with other therapies. To assess disease response and to compare the

Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters.

Jason L Hornick et al.

The American journal of surgical pathology, 27(9), 1183-1196 (2003-09-10)

Myoepitheliomas and mixed tumors were only recently recognized to occur primarily in soft tissue, and only small case numbers have been described. To characterize these tumors further and to evaluate prognostic parameters, 101 myoepithelial tumors of soft tissue were retrieved

Controlled ovarian hyperstimulation leads to high progesterone and estradiol levels during early pregnancy.

Ilkka Y Järvelä et al.

Human reproduction (Oxford, England), 29(11), 2393-2401 (2014-09-11)

Are there differences in estrogen and progesterone secretion in singleton pregnancies, up to Week 11, between spontaneous pregnancies, after controlled ovarian hyperstimulation and fresh embryo transfer (COH + ET) and after frozen embryo transfer in a spontaneous cycle (FET)? Serum

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus.

Kasper S Madsen et al.

The Cochrane database of systematic reviews, 12, CD008558-CD008558 (2019-12-04)

The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could develop into a substantial health problem worldwide. Whether metformin can prevent or delay T2DM and its complications in people with increased risk of developing T2DM is unknown.

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