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D M Richards et al.
Drugs, 26(5), 378-438 (1983-11-01)
Acyclovir (aciclovir) is a nucleoside analogue antiviral drug related to cytarabine, idoxuridine, trifluridine and vidarabine. In common with these earlier antivirals, acyclovir is active against some members of the herpesvirus group of DNA viruses. The efficacy of topical acyclovir has
Darren Svirskis et al.
Pharmaceutical development and technology, 19(5), 571-576 (2013-07-19)
This study aimed at improving the oral bioavailability of acyclovir (ACV) through incorporating it into gastroretentive dosage form based on floating hollow chitosan beads. Hollow chitosan beads were prepared using a solvent free, ionotropic gelation method. The effect of formulation
Martina Prelog et al.
Pediatric nephrology (Berlin, Germany), 26(5), 663-673 (2010-11-16)
Clear recommendations for the management of acute varicella-zoster virus (VZV) infections for cases of significant exposure and the use of prophylactic drugs after solid-organ transplantation are missing due to the lack of evidence by prospective studies. Heterogeneity in patient groups
Clinical problem-solving. A creeping suspicion.
Casey M Rice et al.
The New England journal of medicine, 371(1), 68-73 (2014-07-06)
Secondary viral encephalitis in a patient with pyogenic liver abscess.
N Sahni et al.
Anaesthesia and intensive care, 42(4), 528-530 (2014-06-27)
Mark T Bokhart et al.
Analytical and bioanalytical chemistry, 407(8), 2073-2084 (2014-10-17)
A quantitative mass spectrometry imaging (QMSI) technique using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is demonstrated for the antiretroviral (ARV) drug emtricitabine in incubated human cervical tissue. Method development of the QMSI technique leads to a gain in sensitivity
Nicky Perkins et al.
Sexually transmitted infections, 87(4), 292-295 (2011-03-17)
Infection with herpes simplex virus (HSV) is extremely common worldwide. In immunocompromised patients anogenital HSV disease may have atypical features and may be very severe. Treatment of aciclovir-resistant anogenital HSV disease is challenging, as resistance to alternative treatments may occur
Mona Nasser et al.
The Cochrane database of systematic reviews, (4)(4), CD006700-CD006700 (2008-10-10)
Primary herpetic gingivostomatitis is a highly contagious infection of the oral cavity which typically affects children but can also occur in adults. Symptoms may vary widely from mild discomfort to life-threatening encephalitis. The objective of this review was to evaluate
Prescrire international, 20(119), 205-207 (2011-10-01)
Management of episodes of herpes labialis (cold sores) in otherwise healthy individuals is mainly based on hygiene measures intended to avoid transmitting the virus. At best, topical treatment with aciclovir, an antiviral drug, simply reduces the duration of the episode.
Laurence Le Cleach et al.
The Cochrane database of systematic reviews, 8(8), CD009036-CD009036 (2014-08-05)
Genital herpes is caused by herpes simplex virus 1 (HSV-1) or 2 (HSV-2). Some infected people experience outbreaks of genital herpes, typically, characterized by vesicular and erosive localized painful genital lesions. To compare the effectiveness and safety of three oral
André Engesland et al.
Journal of pharmaceutical sciences, 104(3), 1119-1127 (2015-01-06)
Cost-effective and efficient methods for permeability screening are crucial during early development of drugs, drug formulations, and cosmeceuticals. Alternatives to animal experiments are impelled for both economical and ethical reasons. The aim of this study was to determine the ability
Ahlem Ben Sassi et al.
The Indian journal of medical research, 127(2), 183-192 (2008-04-12)
Tunisian Chrysanthemum species are known to have medicinal activity and some of the species are used in traditional medicine. We have earlier shown the use of C. trifurcatum flowerheads in Tunisian traditional medicine to treat constipation. In the present study
B P Shelley et al.
Journal of the neurological sciences, 252(2), 177-180 (2006-12-22)
This is a case report of PCR proven herpes simplex (HSV-1) encephalitis in a 26 years old immunocompetent adult taking an unusual course of acute intracerebral haematoma after successful and complete recovery with acyclovir therapy. This transient late complication was
Dinah Gould
Nursing standard (Royal College of Nursing (Great Britain) : 1987), 28(33), 52-58 (2014-04-17)
The varicella zoster virus causes two infections: varicella, also known as chickenpox occurring mostly in childhood, and herpes zoster, also known as shingles affecting mainly older people. Varicella usually occurs in children under ten years of age. It is generally
Pierre-André Billat et al.
Analytical and bioanalytical chemistry, 407(12), 3449-3456 (2015-02-24)
Ganciclovir (GCV) is prescribed for cytomegalovirus infection which is a major issue in immunodepressed patients. It is however characterized by hematological toxicity. A better understanding of GCV concentration-effects relationships implies the measurement of intracellular forms. The objective of this study
F Morfin et al.
Annales de biologie clinique, 61(1), 33-40 (2003-02-27)
Herpes simplex virus (HSV) and varicella zoster virus (VZV) are susceptible to acyclovir which inhibits viral replication through two viral enzymes, thymidine kinase (TK) and DNA polymerase. Resistance may occur, it is a rare phenomenon among immunocompetent patients but resistance
María Luisa Mateos-Martín et al.
Analytical and bioanalytical chemistry, 406(22), 5501-5506 (2014-06-28)
Chamaecrista nictitans (L) extract possesses antiviral properties; it acts against the herpes simplex virus, and this may be attributed to its constituent phenolics. Here, high-resolution LC-ESI-MS/MS is used to identify the phenolic components of the most potent fraction of the
T P Klassen et al.
The Cochrane database of systematic reviews, (2)(2), CD002980-CD002980 (2004-04-24)
Acyclovir has the potential to shorten the course of illness which may result in reduced costs and morbidity associated with chickenpox. 1) To examine the evidence evaluating the efficacy of acyclovir in alleviating symptoms of chickenpox and shortening the duration
J Sipe et al.
The Cochrane database of systematic reviews, (4)(4), CD001869-CD001869 (2001-11-01)
The most common disorder of the facial nerve is acute idiopathic facial paralysis or Bell's palsy and there may be significant morbidity or incomplete recovery associated with severe cases. Although the cause remains unknown, recent evidence suggests a possible association
J Sipe et al.
The Cochrane database of systematic reviews, (2)(2), CD001869-CD001869 (2001-06-19)
The most common disorder of the facial nerve is acute idiopathic facial paralysis or Bell's palsy and there may be significant morbidity or incomplete recovery associated with severe cases. Although the cause remains unknown, recent evidence suggests a possible association
Don't let herpes melt your brain!
Paul Jhun et al.
Annals of emergency medicine, 64(6), 589-590 (2014-12-03)
Howell-Jolly body-like inclusions in immunocompromised patients with antiviral treatment.
Cristian Morales-Indiano et al.
Annals of hematology, 93(12), 2091-2092 (2014-05-23)
Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles.
Tavares, Guilherme Diniz, et al.
Quimica nova, 35.1, 203-206 (2012)
Axel Schubert et al.
Antiviral research, 107, 16-22 (2014-04-22)
The role of mutations in the thymidine kinase (TK, UL23) and DNA polymerase (pol, UL30) genes of herpes simplex virus (HSV) for development of different resistance phenotypes has to be exactly determined before genotypic resistance testing can be implemented in
Christophe Vanpouille et al.
Current opinion in infectious diseases, 22(6), 583-587 (2009-09-04)
Epidemiological studies have demonstrated that HIV-1 and herpes simplex virus-2 (HSV-2) are responsible for two epidemics and that, by overlapping in risk populations, they reinforce the spreading of both HIV-1 disease and genital herpes. Randomized controlled trials have investigated whether
Aciclovir and its l-valyl ester, valaciclovir.
M L Smiley et al.
Current problems in dermatology, 24, 209-218 (1996-01-01)
Christopher M Hull et al.
Postgraduate medicine, 122(5), 1-6 (2010-09-30)
Recurrent herpes simplex labialis (HSL), also known as orofacial herpes or cold sores, is a common clinical presentation of herpes simplex virus (HSV) infection. It may manifest as painful, distressing, and cosmetically displeasing vesicles on the lips, nose, and nasal
Keat Choong et al.
Clinical & experimental ophthalmology, 38(3), 309-313 (2010-05-08)
Herpes simplex virus (HSV) keratitis is a common cause of ocular morbidity. Resistance to aciclovir is probably under recognized. We describe three cases of aciclovir-resistant herpes simplex virus keratitis treated with systemic foscarnet and present a review of the pharmacological
S Leflore et al.
Drug safety, 23(2), 131-142 (2000-08-17)
The objective of this article is to review and evaluate risks and benefits associated with the use of acyclovir in the treatment and prophylaxis of common manifestations of herpes simplex virus (HSV) infections in immunocompetent and immunocompromised patients. Information was
Andrew Rowland et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 147-153 (2014-11-09)
This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake by HLM. Uptake affinities (assessed as Kd) of the high- and low-affinity components differed
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