102-16-9

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Manganese superoxide dismutase V16A single-nucleotide polymorphism in the mitochondrial targeting sequence is associated with reduced enzymatic activity in cryopreserved human hepatocytes.

Robert C G Martin et al.

DNA and cell biology, 28(1), 3-7 (2008-09-30)

Mitochondrial manganese superoxide dismutase (MnSOD), encoded by the SOD2 gene, represents a major cellular defense against environmental carcinogens that cause oxidative stress. Two single-nucleotide polymorphisms -9 T>C (V16A in the MnSOD mitochondrial targeting sequence) and -102 C>T (in the SOD2

Progelatinase B/matrix metalloproteinase-9 proenzyme as a marker of pleural inflammation.

Jaromír Kotyza et al.

Experimental lung research, 30(4), 297-309 (2004-06-19)

Previous analyses of pleural effusions of different origin revealed high levels of matrix metalloproteinase-9 proenzyme (proMMP-9), predominantly in parainfectious exudates. To confirm the etiological association with inflammation and to explore time course of release of proMMP-9 under conditions of a

High-resolution array comparative genomic hybridization of chromosome arm 8q: evaluation of genetic progression markers for prostate cancer.

Mark van Duin et al.

Genes, chromosomes & cancer, 44(4), 438-449 (2005-09-01)

Copy number increase of 8q has previously been shown to be associated with a poor clinical outcome and tumor recurrence in patients with prostate cancer. In this study, a detailed genomic analysis of 8q was performed of archival primary and

MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations.

Yongmei Chen et al.

Frontiers in bioscience : a journal and virtual library, 11, 3121-3128 (2006-05-25)

Brain arteriovenous malformations (BAVM) have high matrix metalloproteinase-9 (MMP-9) expression, the source of which is unclear. We hypothesized MMP-9 production might be due to inflammation in BAVM. Compared to control brain tissues (n = 5), BAVM tissue (n = 139)

TNFRSF1B in genetic predisposition to clinical neuropathy and effect on HDL cholesterol and glycosylated hemoglobin in type 2 diabetes.

A V Benjafield et al.

Diabetes care, 24(4), 753-757 (2001-04-24)

Genetic variation in the tumor necrosis factor (TNF) receptor 2 gene (TNFRSF1B) has shown association with insulin resistance in type 2 diabetes, hypercholesterolemia, coronary artery disease, and essential hypertension. Here we tested the TNFRSF1B marker used in the latter studies

Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis.

A Vieira et al.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 44(6), 538-545 (2011-03-30)

β-ionone (βI), a cyclic isoprenoid, and geraniol (GO), an acyclic monoterpene, represent a promising class of dietary chemopreventive agents against cancer, whose combination could result in synergistic anticarcinogenic effects. The chemopreventive activities of βI and GO were evaluated individually or

Plasma thrombopoietin levels in patients with chronic renal failure.

Gabor E Linthorst et al.

The hematology journal : the official journal of the European Haematology Association, 3(1), 38-42 (2002-04-18)

Thrombopoietin (Tpo) is the most important regulator of thrombocytopoiesis. The main sites of Tpo production are the liver and the kidney produce Tpo. In the current study, the influence of renal failure on overall Tpo production was evaluated. Tpo levels

PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3'-kinase pathway alterations might be associated with favorable prognosis.

Ying Dong et al.

Human pathology, 43(8), 1197-1205 (2012-01-03)

The aim of this study was to determine the clinicopathological impact of PIK3CA mutations and phosphatidylinositol 3'-kinase pathway alterations in endometrial cancers in Chinese women. The PIK3CA mutation status was analyzed by sequencing in 94 tumors. The status of phosphatase

Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy.

Lazaros A Nikolaidis et al.

American journal of physiology. Heart and circulatory physiology, 289(6), H2401-H2408 (2005-07-19)

We have shown previously that the glucagon-like peptide-1 (GLP-1)-(7-36) amide increases myocardial glucose uptake and improves left ventricular (LV) and systemic hemodynamics in both conscious dogs with pacing-induced dilated cardiomyopathy (DCM) and humans with LV systolic dysfunction after acute myocardial

The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity.

Karen Borthwick et al.

The Journal of biological chemistry, 281(44), 32946-32952 (2006-08-16)

Carnitine palmitoyltransferase (CPT) 1A adopts a polytopic conformation within the mitochondrial outer membrane, having both the N- and C-terminal segments on the cytosolic aspect of the membrane and a loop region connecting the two transmembrane (TM) segments protruding into the

Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey.

Abdullah Altintas et al.

Annals of hematology, 86(10), 727-731 (2007-06-19)

Factor V Leiden (FV-Leiden) and prothrombin gene mutations (FII G20210A) are well-established independent risk factors for thrombosis. In the recent years, many studies have suggested that these mutations are associated with an increased risk of recurrent pregnancy loss (RPL). We

Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection.

Moyra Machado Portilho et al.

Diagnostics (Basel, Switzerland), 10(10) (2020-10-22)

Serological diagnosis of Zika virus (ZIKV) infection is challenging because of antigenic cross-reactivity with dengue virus (DENV). This study evaluated the accuracy of the Zika IgM antibody capture enzyme-linked immunosorbent assay (CDC Zika IgM MAC-ELISA) in differentiating between ZIKV and

Head and neck squamous cell carcinomas in HIV-positive patients: a preliminary investigation of viral associations.

Michael S McLemore et al.

Head and neck pathology, 4(2), 97-105 (2010-03-25)

Oncogenic human papillomaviruses (HPVs) are associated with oropharyngeal squamous cell carcinoma (SCC). Infection with human immunodeficiency virus (HIV) increases susceptibility to opportunistic infections and viral-promoted cancers. The prevalences of HPV, herpes simplex virus (HSV), Epstein-Barr virus (EBV), and human herpesvirus-8

[Genotyping by CRISPR and regional distribution of Yersinia pestis in Qinghai-plateau from 1954 to 2011].

X Q Xu et al.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 51(3), 237-242 (2017-03-06)

Objective: To investigate the CRISPR genotypes (clusters) and regional distribution of Yersinia pestis in Qinghai-plateau. Methods: One hundred and two isolates of Y. pestis isolated from human plague patients, host animal and insect vectors from Qinghai-plateau were selected. The DNAs

Performance evaluation of a sorbent tube sampling method using short path thermal desorption for volatile organic compounds.

C Y Peng et al.

Journal of environmental monitoring : JEM, 2(4), 313-324 (2001-03-16)

Air sampling, using sorbents, thermal desorption and gas chromatography, is a versatile method for identifying and quantifying trace levels of volatile organic compounds (VOCs). Thermal desorption can provide high sensitivity, appropropriate choices of sorbents and method parameters can accommodate a

BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individuals.

H Sato et al.

Tissue antigens, 70(6), 480-486 (2007-10-12)

Butyrophilin-like 2 (BTNL2) polymorphisms have been associated with sarcoidosis. We hypothesized that BTNL2 variants might confer a human leukocyte antigen (HLA)-independent risk for chronic beryllium disease (CBD), a granulomatous lung disease with similar clinical, radiological, and pathological features to sarcoidosis.

Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats.

S Ishiyama et al.

Circulation, 95(2), 489-496 (1997-01-21)

Excess amounts of NO produced by an inducible NO synthase (iNOS) in response to cytokines may be cytotoxic and can be destructive to tissue. We investigated the role of NO in the development of myocardial damage and the effects of

Neural-humoral responses during head-up tilt in healthy young white and black women.

Sara S Jarvis et al.

Frontiers in physiology, 5, 86-86 (2014-03-14)

Young black women have higher prevalence of hypertension during pregnancy compared to white women, which may be attributable to differences in blood pressure (BP) regulation. We hypothesized that young normotensive black women would demonstrate augmented muscle sympathetic nerve activity (MSNA)

Partial engraftment following plerixafor rescue after failed sibling donor peripheral blood stem cell harvest.

Toby A Eyre et al.

Transfusion, 54(5), 1231-1234 (2013-10-15)

Rarely, healthy donors fail adequate peripheral blood stem cell (PBSC) mobilization. If the recipient has already received conditioning chemotherapy, this can result in the donor undergoing urgent marrow harvest under general anesthesia. Plerixafor is a novel CXCR4 antagonist, licensed for

Pubertal development and fertility in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study.

Lene Molgaard-Hansen et al.

Pediatric blood & cancer, 60(12), 1988-1995 (2013-09-17)

More than 60% of children with acute myeloid leukemia (AML) become long-term survivors. Most are cured using chemotherapy without hematopoietic stem cell transplantation (HSCT). We report on pubertal development and compare self-reported parenthood among AML survivors and their siblings. We

HER2 status in a population-derived breast cancer cohort: discordances during tumor progression.

Ulla Wilking et al.

Breast cancer research and treatment, 125(2), 553-561 (2010-07-16)

This retrospective study investigates the correlation of intra-individual HER2 status between primary breast cancers and corresponding recurrences in a population derived cohort. The REMARK criteria were used as reference. In 151 breast cancer patients, primary tumors were analyzed for HER2

The complete title: The effect of interleukin-28B rs12979860 polymorphism on the therapeutic response of Moroccan patients with chronic hepatitis C.

Kandoussi Nadia et al.

Gene, 568(1), 31-34 (2015-05-11)

There is increasing evidence for the effect of rs12979860 IL28B polymorphism in response to the standard treatment PEG-IFN/RBV (i.e. combination of pegylated interferon and ribavirin) in chronic hepatitis C virus (HCV) infection. The present study aimed to determine the impact

Worse cardiometabolic health in African immigrant men than African American men: reconsideration of the healthy immigrant effect.

Michelle Y O'Connor et al.

Metabolic syndrome and related disorders, 12(6), 347-353 (2014-05-13)

The healthy immigrant effect is a phrase that has been used for decades to describe better cardiometabolic health in African immigrants than African Americans. The recent global increase in cardiometabolic diseases raises the possibility that immigrant health may be changing.

IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin-angiotensin system activity.

A Abdi-Ali et al.

Journal of the renin-angiotensin-aldosterone system : JRAAS, 16(3), 521-528 (2014-01-28)

IgA nephropathy is associated with increased cardiovascular risk, though whether this is due to loss of kidney function or proteinuria is unclear. For this study 10 normotensive IgA nephropathy subjects with early kidney disease (41±5 yrs, glomerular filtration rate (GFR)

A double-blinded, prospective study to define antigenemia and quantitative real-time polymerase chain reaction cutoffs to start preemptive therapy in low-risk, seropositive, renal transplanted recipients.

Elias David-Neto et al.

Transplantation, 98(10), 1077-1081 (2014-05-21)

Cytomegalovirus (CMV) disease occurs in 16% to 20% of low-risk, CMV-positive renal transplant recipients. The cutoffs for quantitative real-time polymerase chain reaction (qPCR) or phosphoprotein (pp65) antigenemia (pp65emia) for starting preemptive therapy have not been well established. We measured qPCR

The structure of the mouse lipoprotein lipase gene: a B1 repetitive element is inserted into the 3' untranslated region of the mRNA.

R Zechner et al.

Genomics, 11(1), 62-76 (1991-09-01)

The catabolism of triglycerides-rich lipoproteins and the subsequent uptake of free fatty acids by muscle and adipose tissue is dependent on the enzyme lipoprotein lipase (LPL). To better understand the regulation of this enzyme, we have isolated and characterized the

Polymorphisms in the APOA1/C3/A4/A5 gene cluster and cholesterol responsiveness to dietary change.

Jaroslav A Hubacek et al.

Clinical chemistry and laboratory medicine, 45(3), 316-320 (2007-03-24)

The relationship between dietary composition and plasma lipids is to some extent genetically determined. It has been found that variants of some genes (e.g., apolipoprotein E and cholesterol 7-alpha hydroxylase) play an important role in changes in plasma lipid levels

Systemic hypotensive effects of testosterone are androgen structure-specific and neuronal nitric oxide synthase-dependent.

Mercedes Perusquía et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 309(2), R189-R195 (2015-05-08)

Testosterone (TES) and other androgens exert a direct vasorelaxing action on the vasculature in vitro that is structurally specific and independent of cytosolic androgen receptor (AR). The effects of intravenous androgen infusions on mean arterial blood pressure (BP) and heart

Adjuvant capecitabine plus bevacizumab versus capecitabine alone in patients with colorectal cancer (QUASAR 2): an open-label, randomised phase 3 trial.

Rachel S Kerr et al.

The Lancet. Oncology, 17(11), 1543-1557 (2016-09-24)

Antiangiogenic agents have established efficacy in the treatment of metastatic colorectal cancer. We investigated whether bevacizumab could improve disease-free survival in the adjuvant setting after resection of the primary tumour. For the open-label, randomised, controlled QUASAR 2 trial, which was

SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity.

Abbas Agaimy et al.

The American journal of surgical pathology, 41(4), 458-471 (2017-03-16)

To more fully characterize the clinical and pathologic spectrum of a recently described tumor entity of the sinonasal tract characterized by loss of nuclear expression of SMARCB1 (INI1), we analyzed 39 SMARCB1-deficient sinonasal carcinomas collected from multiple medical centers. The

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