103-44-6

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Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children.

Jenneke J Keizer-Garritsen et al.

Annals of clinical biochemistry, 40(Pt 1), 86-93 (2003-01-25)

Monitoring 6-thiopurine S-methyltransferase (TPMT; EC 2.1.1.67) activity is especially important when patients are treated with 6-thiopurine drugs, since severe bone marrow toxicity may be induced if patients have deficient TPMT activity. We have developed a method based on high-performance liquid

Frequent expression of CD99 in anaplastic large cell lymphoma: a clinicopathologic and immunohistochemical study of 160 cases.

Daniel Buxton et al.

American journal of clinical pathology, 131(4), 574-579 (2009-03-18)

Originally described as a diagnostically useful marker for Ewing sarcoma, CD99 immunoreactivity has also been documented in a variety of other tumors, including hematopoietic neoplasms. By using conventional paraffin immunoperoxidase staining and tissue microarrays, we retrospectively investigated CD99 expression in

Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.

Emi Hamano et al.

Biochemical and biophysical research communications, 329(4), 1234-1239 (2005-03-16)

We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein

Genetic variation of the platelet- surface integrin GPIIb-IIIa (PIA1/A2-SNP) shows a high association with Type 2 diabetes mellitus.

D Tschoepe et al.

Diabetologia, 46(7), 984-989 (2003-06-27)

The gene encoding the beta(3)-subunit (GPIIIa) of the platelet alpha(2)beta(3)-integrin (fibrinogen receptor) shows a polymorphism PlA1/A2 with the A2 allele putatively associated with an increased risk of acute ischaemic events. This study investigated whether Type 2 diabetes as a particular

Relevance of the inner mitochondrial membrane enzyme F1F0-ATPase as an autoantigen in autoimmune liver disorders.

Beate Preuss et al.

Liver international : official journal of the International Association for the Study of the Liver, 32(2), 249-257 (2011-11-22)

Recently, a non-M2-related mitochondrial 60 kDa protein found to be recognized by antimitochondrial antibody (AMA) negative sera from patients with primary biliary cirrhosis (PBC) has been shown to contain parts of the five F(1)-ATPase subunits α, β, γ, δ and

The anti-inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant.

Jenny-Maria Brozinski et al.

Environmental science & technology, 47(1), 342-348 (2012-11-29)

Pharmaceutical residues are ubiquitous in rivers, lakes, and at coastal waters affected by discharges from municipal wastewater treatment plants. In this study, the presence of 17 different pharmaceuticals and six different phase I metabolites was determined in the bile of

COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils.

Osama Eltboli et al.

BMC pulmonary medicine, 14, 112-112 (2014-07-11)

Eosinophilic airway inflammation is observed in 10-30% of COPD subjects. Whether increased eosinophils or impairment in their clearance by macrophages is associated with the severity and frequency of exacerbations is unknown. We categorised 103 COPD subjects into 4 groups determined

Half-fluence photodynamic therapy in chronic central serous chorioretinopathy.

Eva Smretschnig et al.

Retina (Philadelphia, Pa.), 33(2), 316-323 (2013-01-15)

To evaluate the results of indocyanine green angiography (ICGA)-guided verteporfin (Visudyne®; Novartis Pharma, Switzerland) photodynamic therapy (PDT) with half-fluence rate in the treatment of chronic central serous chorioretinopathy. A retrospective review was conducted of 20 eyes of 19 consecutive patients

Provocation of atrial fibrillation triggers during ablation: does the use of general anesthesia affect inducibility?

Stavros E Mountantonakis et al.

Journal of cardiovascular electrophysiology, 26(1), 16-20 (2014-08-12)

The autonomic nervous system exerts important effects upon atrial fibrillation (AF) initiation. The strategy of anesthesia used during AF ablation may impact the provocation of AF triggers. We hypothesized that the use of general anesthesia (GA) would reduce the incidence

Improved respiratory motion tracking through a novel fiducial marker placement guidance system during electromagnetic navigational bronchoscopy (ENB).

Hayley Stowe et al.

Radiation oncology (London, England), 14(1), 124-124 (2019-07-13)

Stereotactic ablative radiotherapy (SABR) is a treatment option for patients with early stage non-small cell lung cancer (NSCLC) and recurrent or oligometastatic disease who are not surgical candidates. Due to the continuous motion of tumors within the lungs, implementing a

Evaluation of the induction of immune memory following infant immunisation with serogroup C Neisseria meningitidis conjugate vaccines--exploratory analyses within a randomised controlled trial.

Ameneh Khatami et al.

PloS one, 9(7), e101672-e101672 (2014-07-16)

We measured meningococcal serogroup C (MenC)-specific memory B-cell responses in infants by Enzyme-Linked Immunospot (ELISpot) following different MenC conjugate vaccine schedules to investigate the impact of priming on immune memory. Infants aged 2 months were randomised to receive 1 or

Increased risk of breakthrough infection among cytomegalovirus donor-positive/recipient-negative kidney transplant recipients receiving lower-dose valganciclovir prophylaxis.

D R Stevens et al.

Transplant infectious disease : an official journal of the Transplantation Society, 17(2), 163-173 (2015-02-11)

We compared the effectiveness of lower-dose (LD) (450 mg/day for 6 months) to standard-dose (SD) (900 mg/day for 6 months) valganciclovir (VGCV) prophylaxis for prevention of cytomegalovirus (CMV) infection and disease in high-risk CMV donor-positive/recipient-negative (D+/R-) kidney recipients. We performed a single-center, retrospective cohort

Cryopreservation of mobilized blood stem cells at a higher cell concentration without the use of a programmed freezer.

Yoshifumi Kawano et al.

Annals of hematology, 83(1), 50-54 (2003-11-15)

Cryopreservation of peripheral blood stem cells (PBSC) mobilized by chemotherapy combined with or without granulocyte colony-stimulating factor (G-CSF) is an essential part of procedure for anti-cancer strategies. We evaluated whether a higher cell concentration (2 x 10(8)/ml) without the use

Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.

Margaret M Redfield et al.

JAMA, 309(12), 1268-1277 (2013-03-13)

Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF). To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on

Thermal Ablation Induces Transitory Metastatic Growth by Means of the STAT3/c-Met Molecular Pathway in an Intrahepatic Colorectal Cancer Mouse Model.

Haixing Liao et al.

Radiology, 294(2), 464-472 (2019-12-18)

Background Systemic protumorigenic effects have been noted after radiofrequency ablation (RFA) of normal liver and have been linked to an interleukin 6/signal transducer and activator of transcription 3 (STAT3)/hepatocyte growth factor (HGF)/tyrosine-protein kinase Met (c-Met)/vascular endothelial growth factor (VEGF) cytokinetic

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