105-57-7

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Long term follow up of 93 families with myeloproliferative neoplasms: life expectancy and implications of JAK2V617F in the occurrence of complications.

Sandra Malak et al.

Blood cells, molecules & diseases, 49(3-4), 170-176 (2012-07-24)

The long-term evolution of familial myeloproliferative neoplasms was studied in 93 families with 227 subjects including 97 with polycythemia vera (PV), 105 essential thrombocythemia (ET), 14 primary myelofibrosis (PMF) and 11 chronic myeloid leukemia (CML). In PV patients, with 12years

M1 muscarinic receptors contribute to, whereas M4 receptors inhibit, dopamine D1 receptor-induced [3H]-cyclic AMP accumulation in rat striatal slices.

Enrique Sánchez-Lemus et al.

Neurochemical research, 31(4), 555-561 (2006-06-08)

In rat striatal slices labelled with [(3)H]-adenine and in the presence of 1 mM 3-isobutyl-1-methylxantine (IBMX), cyclic [(3)H]-AMP ([(3)H]-cAMP) accumulation induced by the dopamine D(1) receptor agonist SKF-81297 (1 microM; 177 +/- 13% of basal) was inhibited by the general

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

P M Siegel et al.

Molecular and cellular biology, 14(11), 7068-7077 (1994-11-01)

Amplification of the Neu/c-erbB-2 receptor tyrosine kinase has been implicated as an important event in the genesis of human breast cancer. Indeed, transgenic mice bearing either an activated form of neu or the wild-type proto-oncogene under the transcriptional control of

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

P M Siegel et al.

Molecular and cellular biology, 14(11), 7068-7077 (1994-11-01)

In vivo echocardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency.

B D Hoit et al.

Circulation research, 77(3), 632-637 (1995-09-01)

We evaluated the ability of M-mode and Doppler echocardiography to assess left ventricular (LV) function reliably and repeatedly in mice and tested whether these techniques could detect physiological alterations in phospholamban (PLB)-deficient mice. Anesthetized wild-type mice (n = 7) and

Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence.

Shinji Yamamoto et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 21(3), 447-452 (2003-02-01)

Valosin-containing protein (VCP; also known as p97) has been shown to be associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. In this study, association of VCP expression with recurrence of hepatocellular carcinoma (HCC) and

Comparison of assays for the detection of West Nile virus antibodies in equine serum after natural infection or vaccination.

Kinga Joó et al.

Veterinary immunology and immunopathology, 183, 1-6 (2017-01-09)

West Nile virus (WNV) mainly infects birds, horses and humans. Outcomes of the infection range from mild uncharacteristic signs to fatal neurologic disease. The main objectives of the present study were to measure serum IgG and IgM antibodies in naturally

Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance.

Maria Laura Bertolaccini et al.

Thrombosis and haemostasis, 90(4), 636-641 (2003-09-30)

Antibodies directed against protein S (anti-ProtS) may be involved in the development of thrombosis in patients with the antiphospholipid syndrome. We assessed the prevalence and clinical significance of anti-ProtS and evaluated their immunological characteristics in 184 patients with SLE and

Chronic activation of endogenous angiotensin-converting enzyme 2 protects diabetic rats from cardiovascular autonomic dysfunction.

Tatiane M Murça et al.

Experimental physiology, 97(6), 699-709 (2012-01-31)

In this study, we evaluated whether the activation of endogenous angiotensin-converting enzyme 2 (ACE2) would improve the cardiovascular autonomic dysfunction of diabetic rats. Ten days after induction of type 1 diabetes (streptozotocin, 50 mg kg(-1) i.v.), the rats were treated

Helicobacter pylori first-line and rescue treatments in the presence of penicillin allergy.

Javier P Gisbert et al.

Digestive diseases and sciences, 60(2), 458-464 (2014-09-23)

Helicobacter pylori eradication is a challenge in penicillin allergy. To assess the efficacy and safety of first-line and rescue treatments in patients allergic to penicillin. Prospective multicenter study. Patients allergic to penicillin were given a first-line treatment comprising (a) 7-day

Personalised chemotherapy based on tumour marker decline in poor prognosis germ-cell tumours (GETUG 13): a phase 3, multicentre, randomised trial.

Karim Fizazi et al.

The Lancet. Oncology, 15(13), 1442-1450 (2014-12-03)

Poor prognosis germ-cell tumours are only cured in about half of patients. We aimed to assess whether treatment intensification based on an early tumour marker decline will improve progression-free survival for patients with germ-cell tumours. In this phase 3, multicentre

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