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Cheng-Yu Lin et al.
Environmental science & technology, 45(17), 7128-7134 (2011-07-27)
In this study we assessed the interaction between glutathione S-transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies (HTLHF). Research participants comprised 347 male workers, and each participant's cumulative
Sasi Sigawi et al.
Journal of biotechnology, 153(3-4), 138-144 (2011-04-21)
Formaldehyde (FA)-containing indoor air has a negative effect on human health and should be removed by intensive ventilation or by catalytic conversion to non-toxic products. FA can be oxidized by alcohol oxidase (AOX) taking part in methanol metabolism of methylotrophic
Yan-Li Yang et al.
Chinese medical journal, 125(3), 450-454 (2012-04-12)
Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies in China and epidermal growth factor receptor (EGFR) is widely distributed in human epithelial cell membrane. The aim of this study was to investigate the protein overexpression and
Simona Grasso et al.
Foods (Basel, Switzerland), 8(12) (2019-12-19)
The objective of this study was to develop a precise and accurate method to quantify cholesterol in turkey meat products using relative response factors, based on a modification of a previously published method for plant sterols determination. Validation was performed
Peter Korytár et al.
Journal of chromatography. A, 958(1-2), 203-218 (2002-07-24)
Comprehensive two-dimensional gas chromatography (GC x GC) with micro electron-capture detection (microECD) has been optimised for the separation of polychlorinated biphenyl congeners with emphasis on the separation of 12 toxic non- and mono-ortho chlorinated biphenyls (CBs), viz. CBs 77, 81
V C Bradley et al.
Talanta, 221, 121622-121622 (2020-10-21)
High-temperature ammonium bifluoride (ABF) fusions were evaluated for potential use in rapid dissolution of post-detonation nuclear debris. The ABF fusion was carried out in a Pt crucible which allowed evaluation of higher fusion and evaporation temperatures. The high-temperature ABF fusion
Anne M Traynor et al.
Investigational new drugs, 28(1), 91-97 (2009-02-25)
The objective of ECOG 1503 was to determine the response rate of this combination in the second-line treatment of advanced NSCLC. Triapine 105 mg/m(2) IV on days 1, 8, and 15, and gemcitabine 1,000 mg/m(2) on days 1, 8, and
T Peláez et al.
Antimicrobial agents and chemotherapy, 49(3), 1157-1159 (2005-02-25)
We evaluated the in vitro activity of ramoplanin, an antimicrobial compound that inhibits cell wall synthesis by acting at the level of lipid intermediate formation, against Clostridium difficile. We included strains with reduced susceptibilities to vancomycin (vancomycin-intermediate [Van(i)] strains) or
Stephen Z Levine et al.
Schizophrenia research, 145(1-3), 125-127 (2013-02-12)
The treatment and measurement of negative symptoms are currently at issue in schizophrenia, but the clinical meaning of symptom severity and change is unclear. To offer a clinically meaningful interpretation of severity and change scores on the Scale for the
Feng Gao et al.
Radiation research, 180(5), 546-552 (2013-10-18)
Victims of a radiological attack or nuclear accident may receive high-dose, heterogeneous exposures from radiation to the chest that lead to lung damage. Our goal is to develop countermeasures to mitigate such injuries. We used WAG/RijCmcr rats receiving 13 Gy
Moniek G P J Cox et al.
Circulation. Arrhythmia and electrophysiology, 3(2), 126-133 (2010-03-11)
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C) Diagnostic Task Force Criteria (TFC) proposed in 1994 are highly specific but lack sensitivity. A new international task force modified criteria to improve diagnostic yield. A comparison of diagnosis by 1994 TFC versus newly proposed
Eiichi Geshi et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 28(9), 719-725 (2006-01-20)
Imidapril is an angiotensin-converting enzyme inhibitor that is widely used in treating hypertension, although the responses vary among individuals. We investigated whether a single nucleotide polymorphism at position -816 of the carboxylesterase 1 (CES1) gene, which activates imidapril in the
Sébastien Bau et al.
Journal of occupational and environmental hygiene, 17(2-3), 59-72 (2019-12-13)
This study aims to characterize airborne particles emitted from a metal additive manufacturing machine and related levels of occupational exposure. To achieve this, a complete measurement methodology was deployed around a direct energy deposition machine. Different operating conditions were investigated
J Andersson et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 16(5), 743-748 (2005-04-02)
TP53 has been described as a prognostic factor in many malignancies, including breast cancer. Whether it also might be a predictive factor with reference to chemo- and endocrine therapy is more controversial. We investigated relapse-free (RFS), breast cancer-corrected (BCCS) and
W G Carter et al.
The Journal of biological chemistry, 263(9), 4193-4201 (1988-03-25)
We previously identified a 90-kDa cell surface glycoprotein, termed the class III collagen receptor (CRIII), that bound to collagen in affinity chromatography experiments (Wayner, E. A., and Carter, W. G. (1987) J. Cell Biol. 105, 1873-1884). Here, we utilize monoclonal
Maureen Elizabeth Trudeau et al.
SpringerPlus, 4, 631-631 (2015-11-07)
This phase I/II neoadjuvant trial (ClinicalTrials.gov identifier NCT00066443) determined maximally-tolerated doses (MTD), dose-limiting toxicities, response-to-therapy, and explored the role of novel response biomarkers. MA.22 accrued T3N0, any N2 or N3, and T4 breast cancer patients. Treatment was 6 cycles of
Maryam Sharifi-Sanjani et al.
American journal of physiology. Heart and circulatory physiology, 304(10), H1294-H1301 (2013-03-26)
Myocardial metabolites such as adenosine mediate reactive hyperemia, in part, by activating ATP-dependent K(+) (K(ATP)) channels in coronary smooth muscle. In this study, we investigated the role of adenosine A(2A) and A(2B) receptors and their signaling mechanisms in reactive hyperemia.
William J Jo Siu et al.
Antimicrobial agents and chemotherapy, 57(4), 1610-1616 (2013-01-16)
Onychomycosis is a common fungal nail infection in adults that is difficult to treat. The in vitro antifungal activity of efinaconazole, a novel triazole antifungal, was evaluated in recent clinical isolates of Trichophyton rubrum, Trichophyton mentagrophytes, and Candida albicans, common
Herbert L Bonkovsky et al.
The American journal of medicine, 127(12), 1233-1241 (2014-07-13)
Recent descriptions of the clinical and laboratory features of subjects with acute porphyrias in the US are lacking. Our aim was to describe clinical, biochemical, and genetic features of 108 subjects. Between September 2010 and December 2012, 108 subjects with
Tobias Traupe et al.
Journal of cardiovascular pharmacology, 44 Suppl 1, S113-S116 (2005-04-20)
Endothelin has been implicated in arrhythmogenesis. Amiodarone, initially developed for the treatment of angina pectoris, is a potent inhibitor of ventricular arrhythmias. We investigated whether amiodarone (34 microg/mL) affects the vascular endothelin system of healthy Wistar-Kyoto rats. Contractility to big
Sarah Turner et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 23(11), 2462-2472 (2014-08-07)
There is much interest in the development of a cellular therapy for the repair or regeneration of degenerate intervertebral discs (IVDs) utilising autologous cells, with some trials already underway. Clusters of cells are commonly found in degenerate IVDs and are
Trinity Vera et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 292(4), R1472-R1478 (2006-12-30)
Heme oxygenase-1 (HO-1) induction can attenuate the development of angiotensin II (ANG II)-dependent hypertension. However, the mechanism by which HO-1 lowers blood pressure in this model is not clear. The goal of this study was to test the hypothesis that
Tao Yang et al.
Heart rhythm, 7(9), 1246-1252 (2010-07-20)
Emerging evidence has strongly implicated hereditary determinants for atrial fibrillation (AF). Loss-of-function mutations in KCNA5 encoding the ultrarapid delayed rectifier potassium current I(Kur) have been identified in AF families. The purpose of this study was to determine the clinical and
Robert C Barber et al.
Shock (Augusta, Ga.), 30(6), 705-713 (2008-05-08)
Signaling through toll-like receptor 4 (TLR4) plays an obligate role in burn-related myocardial dysfunction. We hypothesized that signaling through CD14, a cellular receptor for endotoxin that lacks a transmembrane domain but is coupled to TLR4, also plays a role in
Simon N Muchohi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(2), 146-152 (2010-12-28)
Clinical pharmacokinetic studies of ciprofloxacin require accurate and precise measurement of plasma drug concentrations. We describe a rapid, selective and sensitive HPLC method coupled with fluorescence detection for determination of ciprofloxacin in human plasma. Internal standard (IS; sarafloxacin) was added
Alberto Farolfi et al.
European journal of cancer (Oxford, England : 1990), 51(14), 1874-1881 (2015-07-25)
To evaluate the optimal time interval from definitive surgery to commencing chemotherapy in early breast cancer (EBC). The relationship between time to initiation of adjuvant chemotherapy (TTC), calculated in weeks, and disease-free (DFS) or overall survival (OS), was assessed in
Rikkert L Snoeckx et al.
American journal of human genetics, 77(6), 945-957 (2005-12-29)
Hearing impairment (HI) affects 1 in 650 newborns, which makes it the most common congenital sensory impairment. Despite extraordinary genetic heterogeneity, mutations in one gene, GJB2, which encodes the connexin 26 protein and is involved in inner ear homeostasis, are
B R Wagle et al.
Poultry science, 99(9), 4566-4577 (2020-09-02)
Campylobacter jejuni is a major foodborne pathogen that causes gastroenteritis in humans. Chickens act as the reservoir host for C. jejuni, wherein the pathogen asymptomatically colonizes the ceca leading to contamination of carcasses during slaughter. The major colonization factors in
Yanghee Woo et al.
Journal of the American College of Surgeons, 230(4), 709-717 (2020-02-08)
Peritoneal carcinomatosis (PC) from pancreatic ductal adenocarcinoma (PDAC) is fatal. Our preclinical study presents an effective treatment against PDAC PC using a novel oncolytic viral agent, CF33-hNIS-antiPDL1. CF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium
Anton Gruber et al.
The Journal of biological chemistry, 279(27), 28475-28482 (2004-04-28)
The receptor complex resulting from association of MD-2 and the ectodomain of Toll-like receptor 4 (TLR4) mediates lipopolysaccharide (LPS) signal transduction across the cell membrane. We prepared a tertiary structure model of MD-2, based on the known structures of homologous
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