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显示 1-30 共 188 条结果 关于 "105228" 范围 论文
Daniel Kanmert et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(30), 10851-10865 (2015-08-01)
Recent evidence suggests that tau aggregation may spread via extracellular release and subsequent uptake by synaptically connected neurons, but little is known about the processes by which tau is released or the molecular forms of extracellular tau. To gain insight
Sarah Tschirner et al.
Molecules (Basel, Switzerland), 23(8) (2018-07-28)
A mixture of hexafluoroisopropanol (HFIP) and water was used as a new and unknown monophasic reaction solvent for fructose dehydration in order to produce HMF. HFIP is a low-boiling fluorous alcohol (b.p. 58 °C). Hence, HFIP can be recovered cost
Monica Dettin et al.
PloS one, 10(9), e0137505-e0137505 (2015-09-12)
The design of hybrid poly-ε-caprolactone (PCL)-self-assembling peptides (SAPs) matrices represents a simple method for the surface functionalization of synthetic scaffolds, which is essential for cell compatibility. This study investigates the influence of increasing concentrations (2.5%, 5%, 10% and 15% w/w
Lara Dresser et al.
Methods (San Diego, Calif.), 193, 80-95 (2020-06-17)
A major hallmark of Alzheimer's disease is the misfolding and aggregation of the amyloid- β peptide (Aβ). While early research pointed towards large fibrillar- and plaque-like aggregates as being the most toxic species, recent evidence now implicates small soluble Aβ
Jie Wang et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(27), 9632-9637 (2015-06-03)
Protein misfolding and abnormal assembly could lead to aggregates such as oligomer, proto-fibril, mature fibril, and senior amyloid plaques, which are associated with the pathogenesis of many amyloid diseases. These irreversible amyloid aggregates typically form in vivo and researchers have
He Xu et al.
ACS applied materials & interfaces, 7(16), 8706-8718 (2015-04-01)
The development of vascular scaffolds with controlled mechanical properties and stimulatory effects on biological activities of endothelial cells still remains a significant challenge to vascular tissue engineering. In this work, we reported an innovative approach to prepare a new type
Huan Zhang et al.
Journal of molecular recognition : JMR, 31(6), e2697-e2697 (2018-01-11)
Dysfunctional accumulation of amyloid β-protein (Aβ) mediated by Cu2+ exhibits higher neurotoxicity and accelerates the progress of Alzheimer's disease, so inhibition of Cu2+ -mediated Aβ aggregation and cytotoxicity has been considered as a therapeutic strategy for the disease. Herein, a
Asta Lučiūnaitė et al.
Journal of neurochemistry, 155(6), 650-661 (2019-12-25)
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder causing memory loss, language problems and behavioural disturbances. AD is associated with the accumulation of fibrillar amyloid-β (Aβ) and the formation of neurofibrillary tau tangles. Fibrillar Aβ itself represents a danger-associated
Janka Kubincová et al.
Journal of chromatography. A, 1219, 173-176 (2011-12-06)
The developed method for trace analysis of volatile components in plasma allows direct injection of up to 150 samples to the GC-MS/MS system without injector cleaning. This method requires no modification of plasma and the working environment does not interfere
Timothy L Downing et al.
Journal of controlled release : official journal of the Controlled Release Society, 161(3), 910-917 (2012-05-29)
Spinal cord injury (SCI) remains a major challenge for regenerative medicine. Following SCI, axon growth inhibitors and other inflammatory responses prevent functional recovery. Previous studies have demonstrated that rolipram, an anti-inflammatory and cyclic adenosine monophosphate preserving small molecule, improves spinal
Daniel J Whitcomb et al.
Scientific reports, 5, 10934-10934 (2015-06-10)
The acute neurotoxicity of oligomeric forms of amyloid-β 1-42 (Aβ) is implicated in the pathogenesis of Alzheimer's disease (AD). However, how these oligomers might first impair neuronal function at the onset of pathology is poorly understood. Here we have examined
K Hoehlig et al.
British journal of pharmacology, 172(12), 3086-3098 (2015-02-11)
Calcitonin gene-related peptide (CGRP) plays an important role in the pathology of migraine, and recent clinical trials suggest the inhibition of CGRP-mediated processes as a new therapeutic option in migraine. In this study, we describe the generation of NOX-L41, a
Leyuan Xu et al.
Pharmaceutical research, 32(1), 275-285 (2014-07-18)
This work was aimed at developing a semi-interpenetrating network (sIPN) co-electrospun gelatin/insulin fiber scaffold (GIF) formulation for transbuccal insulin delivery. Gelatin was electrospun into fibers and converted into an sIPN following eosin Y-initiated polymerization of polyethylene glycol diacrylate (PEG-DA). The
Shujun Xu et al.
Neuroscience letters, 578, 7-11 (2014-06-17)
Rosiglitazone has been known to attenuate neurodegeneration in Alzheimer's disease (AD), but the underlying mechanisms remain unclear. In this study, Morris water maze test, ELISA and electrophysiological methods were used to examine the role and underling mechanisms of rosiglitazone on
Lawrence W Dick et al.
Human vaccines & immunotherapeutics, 11(6), 1518-1525 (2015-05-23)
The development of a multivalent outer membrane vesicle (OMV) vaccine where each strain contributes multiple key protein antigens presents numerous analytical challenges. One major difficulty is the ability to accurately and specifically quantitate each antigen, especially during early development and
Hyo Geun Kim et al.
Canadian journal of physiology and pharmacology, 92(6), 429-437 (2014-05-14)
Microglia-mediated inflammation is a major pathological mechanism contributing to Alzheimer's disease (AD), and has been proposed as a potential therapeutic target. Chunghyuldan (CHD; Qingxue-dan in Chinese and Daio-Orengedokuto in Japanese) possesses wide-ranging biological effects, including anti-hyperlipidemic, anti-stroke, anti-inflammatory, and antioxidant
Junlong Song et al.
Journal of colloid and interface science, 454, 89-96 (2015-05-26)
The adsorption of polyalkylene glycols and co-polymers of ethylene oxide and propylene oxide on substrates relevant to textiles with varying surface energies (cellulose, polypropylene, nylon and polyester) was studied by using quartz crystal microgravimetry. Langmuirian-type isotherms were observed for the
Noboru Kuboyama et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 101(2), 295-302 (2012-11-06)
Porous scaffolds were prepared using regenerated Bombyx mori silk fibroin dissolved in water or hexafluoroisopropanol (HFIP). The effects of these two preparations on the formation and growth of new bone on implantation into the rabbit femoral epicondyle was examined. The
Sara Vieira et al.
Colloids and surfaces. B, Biointerfaces, 167, 310-317 (2018-04-22)
Fish sarcoplasmic proteins (FSP) constitute around 25-30% of the total fish muscle protein. As the FSP are water soluble, FSP were isolated from fresh cod (Gadus morhua) by centrifugation. By SDS-PAGE, it was possible to determine the composition of FSP
Chinnasamy Gandhimathi et al.
Materials science & engineering. C, Materials for biological applications, 49, 776-785 (2015-02-18)
Mimicking native extracellular matrix with electrospun porous bio-composite nanofibrous scaffolds has huge potential in bone tissue regeneration. The aim of this study is to fabricate porous poly(l-lactic acid)-co-poly-(ε-caprolactone)/silk fibroin/ascorbic acid/tetracycline hydrochloride (PLACL/SF/AA/TC) and nanohydroxyapatite (n-HA) was deposited by calcium-phosphate dipping
Koutaro Takamatsu et al.
Stem cell research, 13(3 Pt A), 442-453 (2014-12-03)
The purpose of this study was to evaluate the therapeutic potential of human induced pluripotent stem (iPS) cell-derived macrophage-like cells for Alzheimer's disease (AD). In previous studies, we established the technology to generate macrophage-like myeloid lineage cells with proliferating capacity
Jessica Perkins et al.
Journal of biomedical materials research. Part A, 102(12), 4290-4300 (2014-02-06)
The surface modification of metallic biomaterials is of critical importance to enhance the biocompatibility of surgical implant materials and devices. This article investigates the use of a direct-write inkjet technique for multilayer coatings of a biodegradable polymer (polyester urethane urea
Haiqiang Wu et al.
PloS one, 9(10), e109438-e109438 (2014-10-03)
Inhibition of β-amyloid (Aβ) aggregation is an attractive therapeutic and preventive strategy for the discovery of disease-modifying agents in Alzheimer's disease (AD). Phomopsis occulta is a new, salt-tolerant fungus isolated from mangrove Pongamia pinnata (L.) Pierre. We report here the
Yosef Koronyo et al.
Brain : a journal of neurology, 138(Pt 8), 2399-2422 (2015-06-07)
Weekly glatiramer acetate immunization of transgenic mice modelling Alzheimer's disease resulted in retained cognition (Morris water maze test), decreased amyloid-β plaque burden, and regulation of local inflammation through a mechanism involving enhanced recruitment of monocytes. Ablation of bone marrow-derived myeloid
Yi-An Lin et al.
ACS nano, 8(12), 12690-12700 (2014-11-22)
Mixing of oppositely charged amphiphilic molecules (catanionic mixing) offers an attractive strategy to produce morphologies different from those formed by individual molecules. We report here on the use of catanionic mixing of anticancer drug amphiphiles to construct multiwalled nanotubes containing
Yong Cheol Shin et al.
International journal of nanomedicine, 9, 4067-4078 (2014-09-05)
This study concentrates on the development of biodegradable nanofiber membranes with controlled drug release to ensure reduced tissue adhesion and accelerated healing. Nanofibers of poly(lactic-co-glycolic acid) (PLGA) loaded with epigallocatechin-3-O-gallate (EGCG), the most bioactive polyphenolic compound in green tea, were
Elham Vatankhah et al.
Biopolymers, 101(12), 1165-1180 (2014-07-22)
Tissue engineering techniques particularly using electrospun scaffolds have been intensively used in recent years for the development of small diameter vascular grafts. However, the development of a completely successful scaffold that fulfills multiple requirements to guarantee complete vascular regeneration remains
Zachery Moore et al.
Scientific reports, 10(1), 3153-3153 (2020-02-23)
Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogenesis. Critical to the process of neuroinflammation are the type-I interferon (IFN) family of cytokines. Efforts to phenotypically characterize microglia within AD identify distinct populations
Yadong Liu et al.
Acta biomaterialia, 10(12), 5074-5080 (2014-09-10)
Blends of aniline pentamer-graft-gelatin (AP-g-GA) and poly(l-lactide) (PLLA) were electrospun to prepare uniform nanofibers as biomimetic scaffolds. The nanofibers exhibited good electroactivity, thermal stability and biodegradability. The biocompatibility of the nanofibers in vitro was evaluated by the adhesion and proliferation
P Sun et al.
British journal of pharmacology, 172(22), 5390-5402 (2015-09-13)
Stroke and Alzheimer's disease (AD) are related pathologies in which the cerebrovascular system is involved. Plasma levels of semicarbazide-sensitive amine oxidase/vascular adhesion protein 1 (SSAO/VAP-1, also known as Primary Amine Oxidase -PrAO) are increased in both stroke and AD patients
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