106-23-0

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AcSDKP is down-regulated in anaemia induced by Trypanosoma brucei infection in mice.

Janelisa Musaya et al.

Malawi medical journal : the journal of Medical Association of Malawi, 29(3), 259-264 (2018-06-07)

Anaemia commonly results from destruction of erythrocytes in the peripheral blood and failure of the bone marrow haematopoietic cells to replenish the erythrocytes. The mechanisms involved in trypanosoma-induced anaemia, including the role of the bone marrow haematopoietic cells are incompletely

Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial.

Martin Markowitz et al.

The lancet. HIV, 4(8), e331-e340 (2017-05-27)

Cabotegravir (GSK1265744) is an HIV-1 integrase strand transfer inhibitor with potent antiviral activity and a long half-life when administered by injection that prevented simian-HIV infection upon repeat intrarectal challenge in male macaques. We aimed to assess the safety, tolerability, and

Growth hormone receptor expression in brain tumors.

Tetsuhiko Sakoguchi et al.

Hiroshima journal of medical sciences, 61(1), 1-6 (2012-06-19)

Growth hormone (GH) is essential for quality of life in both children and adults, but it is also believed to enhance the growth of various neoplasms. However, the role of GH in the brain, particularly in brain tumors, has yet

Detection of an MEN1 gene mutation depends on clinical features and supports current referral criteria for diagnostic molecular genetic testing.

S Ellard et al.

Clinical endocrinology, 62(2), 169-175 (2005-01-27)

Diagnostic molecular genetic testing for multiple endocrine neoplasia type 1 (MEN1) has been available since the identification of the MEN1 gene in 1997. Mutation screening of the MEN1 gene has been recommended for patients who meet clinical criteria for MEN1

Aerobic cometabolism of chloroform by butane-grown microorganisms: long-term monitoring of depletion rates and isolation of a high-performing strain.

Dario Frascari et al.

Biodegradation, 16(2), 147-158 (2005-02-26)

The focus of this microcosm study was to monitor the performances of 17 butane-utilizing microcosms during a long-term (100-250 days) aerobic cometabolic depletion of chloroform (CF). The depletion of the contaminant began after a lag-time variable between 0 and 23

Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol.

G Haeseler et al.

European journal of anaesthesiology, 19(8), 571-579 (2002-08-31)

Thymol is a naturally occurring phenol derivative used in anaesthetic practice as a stabilizer and preservative of halothane, usually at a concentration of 0.01%. Although analgesic effects have long been described for thymol and its structural homologue menthol, a molecular

Prevalence and significance of anti-peptidylarginine deiminase 4 antibodies in rheumatoid arthritis.

Jinxia Zhao et al.

The Journal of rheumatology, 35(6), 969-974 (2008-04-10)

To detect anti-peptidylarginine deiminase 4 (PAD4) antibody in patients with rheumatoid arthritis (RA) and to investigate its clinical significance in the pathogenesis of RA. Serum samples were obtained from 109 patients with RA, 67 systemic lupus erythematosus (SLE), 48 primary

Early T precursor acute lymphoblastic leukaemia/lymphoma shows differential immunophenotypic characteristics including frequent CD33 expression and in vitro response to targeted CD33 therapy.

Haitham Khogeer et al.

British journal of haematology, 186(4), 538-548 (2019-05-23)

The differential immunophenotypic characteristics of early T precursor (ETP) acute lymphoblastic leukaemia/lymphoma (ALL) remain incompletely characterized. The study group (n = 142) included 106 (74·7%) men and 36 (25·3%) women with a median age of 34·9 years (range, 2-79) at diagnosis. Patients were

Metabolic disorders in Turkish children with urolithiasis.

Mehmet Halil Celiksoy et al.

Urology, 85(4), 909-913 (2015-03-31)

To review metabolic disorders in Turkish children with urinary tract stone disease. The medical records of 308 pediatric patients with the diagnosis of urolithiasis between 1996 and 2008, whose disease progression was followed in a single tertiary-care center, were reviewed

Endophytic Beauveria bassiana promotes drought tolerance and early flowering in corn.

Laiju Kuzhuppillymyal-Prabhakarankutty et al.

World journal of microbiology & biotechnology, 36(3), 47-47 (2020-03-08)

Beauveria bassiana (Bals.) Vuillemin (B. bassiana) is an entomopathogenic fungus that establishes endophytic symbiosis with plants. In the present study, the effects of B. bassiana strains colonization in growing Zea mays L. (Z. mays), crop production, and drought tolerance were evaluated.

Composition-property relationships for radiopaque composite materials: pre-loaded drug-eluting beads for transarterial chemoembolization.

Nancy Kilcup et al.

Journal of biomaterials applications, 30(1), 93-103 (2015-02-19)

The purpose of this study was to synthesize and optimize intrinsically radiopaque composite embolic microspheres for sustained release of doxorubicin in drug-eluting bead transarterial chemoembolization. Using a design of experiments approach, 12 radiopaque composites composed of polylactic-co-glycolic acid and a

SATB2 in neuroendocrine neoplasms: strong expression is restricted to well-differentiated tumours of lower gastrointestinal tract origin and is most frequent in Merkel cell carcinoma among poorly differentiated carcinomas.

Andrew M Bellizzi

Histopathology, 76(2), 251-264 (2019-06-25)

Special AT-rich sequence-binding protein 2 (SATB2) is a transcriptional regulator with critical roles in brain, craniofacial and skeletal development. It has emerged as a key marker of lower gastrointestinal (GI) tract columnar epithelial and osteoblastic differentiation. Transcription factor immunohistochemistry is

Evaluating the Concordance of Clinician Antiretroviral Prescribing Practices and HIV-ASSIST, an Online Clinical Decision Support Tool.

Jesus A Ramirez et al.

Journal of general internal medicine, 35(5), 1498-1503 (2019-12-04)

Individualized selection of antiretroviral (ARV) therapy is complex, considering drug resistance, comorbidities, drug-drug interactions, and other factors. HIV-ASSIST (www.hivassist.com) is a free, online tool that provides ARV decision support. HIV-ASSIST synthesizes patient and virus-specific attributes to rank ARV combinations based

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial.

Andrew Blauvelt et al.

Lancet (London, England), 389(10086), 2287-2303 (2017-05-10)

Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous allergic diseases ranging from asthma to atopic dermatitis. Previous 16-week monotherapy studies showed that dupilumab substantially improved signs and symptoms of

Thalidomide before and after autologous stem cell transplantation in recently diagnosed multiple myeloma (HOVON-50): long-term results from the phase 3, randomised controlled trial.

Niels Wcj van de Donk et al.

The Lancet. Haematology, 5(10), e479-e492 (2018-10-07)

In patients with recently diagnosed multiple myeloma, the HOVON-50 phase 3 trial showed improved event-free survival for thalidomide-containing induction and maintenance regimens (in conjunction with high-dose melphalan and autologous stem cell transplantation [auto-SCT]) after a median of 52 months of

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