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Manutsanun Sumonwiriya et al.
PLoS neglected tropical diseases, 11(9), e0005846-e0005846 (2017-09-12)
Scrub typhus is a febrile infection caused by the obligate intracellular bacterium Orientia tsutsugamushi, which causes significant morbidity and mortality across the Asia-Pacific region. The control of this vector-borne disease is challenging due to humans being dead-end hosts, vertical maintenance
Isaac James et al.
The Journal of surgical research, 229, 243-253 (2018-06-26)
Adipose-derived stem cells (ASCs) are capable of secreting regenerative growth factors and replacing multiple tissue types. Although current literature suggests that ASCs accelerate wound healing and reduce scarring, the dose-response relationship has not been adequately investigated in large animals. We
Ulrike Lass et al.
PloS one, 7(7), e41298-e41298 (2012-07-31)
To investigate the dynamics of inter- and intratumoral molecular alterations during tumor progression in recurrent gliomas. To address intertumoral heterogeneity we investigated non-microdissected tumor tissue of 106 gliomas representing 51 recurrent tumors. To address intratumoral heterogeneity a set of 16
Yao Wang et al.
Oncoimmunology, 7(7), e1440169-e1440169 (2018-06-15)
Expressed by cancer stem cells of various epithelial cell origins, CD133 is an attractive therapeutic target for cancers. Autologous chimeric antigen receptor-modified T-cell directed CD133 (CART-133) was first tested in this trial. The anti-tumor specificity and the postulated toxicities of
David R Snydman et al.
The Journal of antimicrobial chemotherapy, 73(8), 2078-2084 (2018-05-03)
We evaluated the antimicrobial susceptibility and ribotypes of Clostridium difficile isolates from participants in a Phase 2 study of ridinilazole, a novel targeted-spectrum agent for treatment of C. difficile infection. Participants received ridinilazole (200 mg twice daily) or vancomycin (125 mg four
J T Jang et al.
The Journal of nutrition, 130(5), 1291-1296 (2000-05-10)
In view of evidence that nutritional status of iron and vitamin A may affect the other nutrient's metabolism, we used model-based compartmental analysis to examine effects of iron deficiency on whole-body vitamin A dynamics in rats. Weanling male Sprague-Dawley rats
Jennifer Dunlap et al.
American journal of clinical pathology, 135(5), 709-719 (2011-04-20)
Myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms are heterogeneous disorders. JAK2 mutation testing and karyotyping are routinely used for diagnosis but have not been incorporated into risk stratification in Philadelphia chromosome-negative myeloproliferative neoplasms. This study correlated cytogenetic abnormalities with disease stage and
Thierry Burnouf et al.
Analytical biochemistry, 389(1), 69-73 (2009-03-24)
The capacity of hydrophobic octadecyl (C18) and SDR HyperD materials to remove the combination of 1% (v/v) solvent (tri-n-butyl phosphate, TnBP) with 1% (v/v) nonionic detergents (Triton X-100 and Triton X-45) used for viral inactivation of plasma-derived polyvalent intravenous immunoglobulin
Paulo Castro-Chaves et al.
European journal of pharmacology, 544(1-3), 91-96 (2006-07-18)
We analyzed the influence of endothelin-1 and endocardial endothelium on the myocardial effects of angiotensin-II. Angiotensin-II (10(-9)-10(-5) M) was tested in rabbit right papillary muscles in absence (Protocol-A) or presence of PD-145065 (10(-7) M; Protocol-B), BQ-123 (10(-7) M; Protocol-C) or
Mengchun Gao et al.
Journal of basic microbiology, 44(6), 424-429 (2004-11-24)
A novel analytical method was applied for identification of isoprenoid quinones in Escherichia coli by liquid chromatography atmospheric press chemical ionization mass spectrometry in negative mode (LC-NI-APCI-MS). Extraction and clean-up of sample were carried out on Sep-Pak Plus Silica solid-phase
Bei Jia et al.
Chemotherapy, 56(4), 285-290 (2010-08-18)
Biapenem is an injectable carbapenem antibiotic. A clinical study was designed to evaluate its efficacy and safety in the treatment of respiratory and urinary infections compared to imipenem/cilastatin. A total of 216 patients with respiratory or urinary tract infections were
Patrick S Lown et al.
Protein engineering, design & selection : PEDS, 34 (2021-04-22)
Selections of yeast-displayed ligands on mammalian cell monolayers benefit from high target expression and nanomolar affinity, which are not always available. Prior work extending the yeast-protein linker from 40 to 80 amino acids improved yield and enrichment but is hypothesized
Li-feng Huang et al.
Cytokine, 53(1), 29-34 (2010-10-29)
The study was performed to observe the systemic release and kinetics of high mobility group box-1 protein (HMGB1) in burned patients. 106 patients were included, and they were divided into three groups with different burn sizes: group I, group II
Ryota Tsunekuni et al.
Avian diseases, 61(3), 296-306 (2017-09-29)
Recombinant Newcastle disease virus (rNDV) expressing the hemagglutinin of highly pathogenic avian influenza virus (HPAIV HA) induces protective immunity against HPAIV in chickens. However, the efficacy of rNDV vectors is hampered when chickens are pre-immune to NDV, and most commercial
Minoru Yoshida et al.
Genes, chromosomes & cancer, 35(4), 359-364 (2002-10-16)
It has been documented that renal cell carcinomas (RCCs) occur frequently in patients treated with long-term dialysis, especially in cases of end-stage renal disease (ESRD)/acquired cystic disease of the kidney (ACDK). To address the molecular pathogenesis of ESRD/ACDK-associated RCCs, we
Daniela Cabibi et al.
Medical science monitor : international medical journal of experimental and clinical research, 15(5), CR203-CR210 (2009-04-28)
The role of Barrett esophagus in carcinogenesis is widely accepted, but the significance of esophageal columnar mucosa without histological intestinal metaplasia, known as columnar-lined esophagus, is debated. We studied 128 patients free of Helicobacter pylori with reflux-related symptoms and columnar
Jin-Shing Chen et al.
Lancet (London, England), 381(9874), 1277-1282 (2013-03-16)
Simple aspiration and drainage is a standard initial treatment for primary spontaneous pneumothorax, but the rate of pneumothorax recurrence is substantial. We investigated whether additional minocycline pleurodesis after simple aspiration and drainage reduces the rate of recurrence. In our open-label
M R Davis et al.
International journal of cancer, 52(6), 881-886 (1992-12-02)
Malignant mesothelioma (MM) is an aggressive tumour of the serosal cavities which is associated with previous asbestos exposure and is generally found to be resistant to conventional forms of therapy. Adequate scientific and clinical assessment of this disease has been
E M Costa et al.
The Journal of clinical endocrinology and metabolism, 86(6), 2680-2686 (2001-06-09)
Several point mutations in the GnRH receptor gene have been described in an autosomal recessive form of congenital isolated hypogonadotropic hypogonadism (HH). We investigated 17 Brazilian patients (10 males and 7 females) from 14 different families, with HH and normal
L B Jensen et al.
Cancer biomarkers : section A of Disease markers, 5(1), 41-49 (2009-02-27)
Uncontrolled growth of cancer cells can be related to dysfunctional cell cycle control, including entry into S-phase, initiating cell division. Cyclin CCND3 and CCNE1 along with CDK2 and CDK6 regulate this checkpoint, and genetic changes, detectable by fluorescence in situ
Siew-Kim Khoo et al.
The Journal of allergy and clinical immunology, 113(3), 475-481 (2004-03-10)
The IL12B gene encodes the p40 chain of IL-12, a proinflammatory cytokine that antagonizes TH2 expression and hence may play a critical role in the pathogenesis of airway inflammation observed in asthma. A promoter polymorphism of the gene was recently
Lieke W J van den Elsen et al.
The Journal of nutrition, 144(12), 1970-1976 (2014-10-25)
Supplementation with long-chain n-3 polyunsaturated fatty acids (LCPUFAs) has been found to reduce the development of allergic disease. The aim of this study was to compare the effectiveness of fish oil diets rich in eicosapentaenoic acid (20:5n-3; EPA) or docosahexaenoic
J-E Eom et al.
Vox sanguinis, 107(2), 181-187 (2014-02-13)
Transplantation of cryopreserved umbilical cord blood (UCB) can be used to treat a multitude of haematologic and immunological diseases. In this study, we examined the quality of UCB cryopreserved for 2 (group I), 4 (group II) and 6 (group III)
Laiju Kuzhuppillymyal-Prabhakarankutty et al.
World journal of microbiology & biotechnology, 36(3), 47-47 (2020-03-08)
Beauveria bassiana (Bals.) Vuillemin (B. bassiana) is an entomopathogenic fungus that establishes endophytic symbiosis with plants. In the present study, the effects of B. bassiana strains colonization in growing Zea mays L. (Z. mays), crop production, and drought tolerance were evaluated.
Rupal P Soder et al.
Stem cell reviews and reports, 16(5), 979-991 (2020-08-03)
Because of their well-described immunosuppressive properties, allogeneic adult human mesenchymal stromal cells (MSC) derived from bone marrow have demonstrated safety and efficacy in steroid refractory acute graft versus host disease (SR aGVHD). Clinical trials have resulted in variable success and
Marianita Perez-Gonzalez et al.
Journal of AOAC International, 98(6), 1752-1759 (2015-12-15)
An ultra-performance LC (UPLC) method was developed to determine the manufacturing intermediates and subsidiary colors in the monosulfo monoazo color additives D&C Red No. 6 and D&C Red No. 7 and their lakes. This method is intended for use in
Emma Jane Gault et al.
BMJ (Clinical research ed.), 342, d1980-d1980 (2011-04-16)
To examine the effect of oxandrolone and the timing of pubertal induction on final height in girls with Turner's syndrome receiving a standard dose of growth hormone. Randomised, double blind, placebo controlled trial. Setting 36 paediatric endocrinology departments in UK
Guoping Zheng et al.
Respiratory research, 18(1), 119-119 (2017-06-18)
Long-term survival of lung transplantation is hindered by the development of obliterative bronchiolitis (OB). Adipose-derived stem cells (ASCs) were documented to have more potent immunosuppressive ability than mesenchymal stem cells (MSCs) from bone marrow and placenta. The goal of our
Shangkui Xie et al.
Arthritis and rheumatism, 52(2), 659-667 (2005-02-05)
(SWR x NZB)F(1) (or SNF(1)) hybrid mice succumb to lupus nephritis. A previous analysis of SNF(1) x NZB backcross mice revealed the existence of 4 SWR loci (H2 on chromosome 17, Swrl-1 on chromosome 1, Swrl-2 on chromosome 14, and
Omkar Byadgi et al.
Veterinary immunology and immunopathology, 234, 110217-110217 (2021-03-02)
The ectoparasite protozoan Amyloodinium ocellatum (AO) is the causative agent of amyloodiniosis in European seabass (ESB, Dicentrarchus labrax). There is a lack of information about basic molecular immune response mechanisms of ESB during AO infestation. Therefore, to compare gene expression
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