108-40-7

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Mutational analysis of CDKN2A gene in a group of 390 larynx cancer patients.

Katarzyna Kiwerska et al.

Molecular biology reports, 37(1), 325-332 (2009-08-20)

CDKN2A gene belongs to the genes involved in cell cycle regulation. When is absent or inactivated by mutation or promoter hypermethylation a cell may undertake an uncontrolled proliferation. Inactivation of CDKN2A gene is observed in many human malignancies, including larynx

Quantitative analysis of cell surface-associated SV40 large T antigen using a newly developed 3H-protein A binding assay.

Y Rinke et al.

Virology, 170(2), 424-432 (1989-06-01)

We have established a sensitive assay for the quantitative determination of large T antigen determinants on the surface of living simian virus 40 (SV40)-transformed cells (mKSA). Cells in suspension culture were incubated with monoclonal antibodies specific for large T antigen

[Simultaneous determination of captan and folpet pesticide residues in apples by solid-phase extraction and high performance liquid chromatography].

Shuju Wang et al.

Se pu = Chinese journal of chromatography, 25(2), 226-229 (2007-06-22)

A method for the simultaneous determination of captan and folpet pesticide residues in apples was developed by solid-phase extraction and high performance liquid chromatography. The sample was extracted with acetonitrile and cleaned-up by a mixture of homemade sorbent and silica

FDG uptake observed around the lumbar spinous process: relevance to Baastrup disease.

Kayo Nishimatsu et al.

Annals of nuclear medicine, 29(9), 766-771 (2015-07-15)

In positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG), non-tumorous focal uptake is often observed around the lumbar spinous processes (LSPs). Close approximation of LSPs with sclerosis is often seen, which is called Baastrup disease. The aim of this study was

Simple aspiration and drainage and intrapleural minocycline pleurodesis versus simple aspiration and drainage for the initial treatment of primary spontaneous pneumothorax: an open-label, parallel-group, prospective, randomised, controlled trial.

Jin-Shing Chen et al.

Lancet (London, England), 381(9874), 1277-1282 (2013-03-16)

Simple aspiration and drainage is a standard initial treatment for primary spontaneous pneumothorax, but the rate of pneumothorax recurrence is substantial. We investigated whether additional minocycline pleurodesis after simple aspiration and drainage reduces the rate of recurrence. In our open-label

Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas.

Ping Yang et al.

Cancer, 103(11), 2363-2372 (2005-04-19)

Deletions of 19q have been associated with gliomas, especially oligodendrogliomas. In addition, cases with oligodendrogliomas with the 19q deletion have been observed to have a better survival compared with cases without the 19q deletion. The authors have previously described a

Immunohistochemical analysis of cyclin A, cyclin D1 and P53 in mammary tumors, squamous cell carcinomas and basal cell tumors of dogs and cats.

Y Murakami et al.

The Journal of veterinary medical science, 62(7), 743-750 (2000-08-17)

The involvement of cyclin A, cyclin D1 and p53 proteins in canine and feline tumorigenesis was analyzed immunohistochemically. In the present study, a total of 176 cases were examined, among which there were 108 canine cases (75 mammary lesions, 16

Mobilization of CD34-positive bone marrow-derived cells after coronary stent implantation: impact on restenosis.

Teruo Inoue et al.

Circulation, 115(5), 553-561 (2007-01-31)

Recently, accumulating evidence has indicated that bone marrow-derived stem cells are capable of differentiating into vascular cells. It has been hypothesized that the inflammatory response after vascular injury triggers the mobilization of endothelial and smooth muscle progenitor cells from bone

Polymorphisms of the angiotensin converting enzyme gene in early-onset and late-onset pre-eclampsia.

Ramalingam Uma et al.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 23(8), 874-879 (2010-01-05)

The aim of this study was to investigate differences in maternal and infant ACE genotypes in early-onset and later-onset pre-eclampsia/toxemia (PET). We conducted a case-control study of 22 cases of early-onset pre-eclampsia (before 34 weeks gestation), 38 cases of later-onset

A high incidence of MSH6 mutations in Amsterdam criteria II-negative families tested in a diagnostic setting.

D Ramsoekh et al.

Gut, 57(11), 1539-1544 (2008-07-16)

In Lynch syndrome, the clinical phenotype in MSH6 mutation families differs from that in MLH1 and MSH2 families. Therefore, MSH6 mutation families are less likely to fulfil diagnostic criteria such as the Amsterdam II criteria (AC II) and the revised

Single-nucleotide polymorphisms in base excision repair, nucleotide excision repair, and double strand break genes as markers for response to radiotherapy in patients with Stage I to II head-and-neck cancer.

Joan Carles et al.

International journal of radiation oncology, biology, physics, 66(4), 1022-1030 (2006-09-19)

Polymorphisms in DNA repair genes can influence response to radiotherapy. We analyzed single-nucleotide polymorphisms (SNP) in nine DNA repair genes in 108 patients with head-and-neck cancer (HNSCC) who had received radiotherapy only. From May 1993 to December 2004, patients with

The clinical expression of hemochromatosis in Oslo, Norway. Excessive oral iron intake may lead to secondary hemochromatosis even in HFE C282Y mutation negative subjects.

H Bell et al.

Scandinavian journal of gastroenterology, 35(12), 1301-1307 (2001-02-24)

The prevalence of hereditary hemochromatosis in Norway is one of the highest reported in the world. However, the clinical presentation in patients with hemochromatosis in Norway seems to be different compared with recent studies elsewhere. The aim of this study

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.

K Bettayeb et al.

Oncogene, 27(44), 5797-5807 (2008-06-25)

Among the ten pharmacological inhibitors of cyclin-dependent kinases (CDKs) currently in clinical trials, the purine roscovitine (CYC202, Seliciclib) is undergoing phase 2 trials against non-small-cell lung and nasopharyngeal cancers. An extensive medicinal chemistry study, designed to generate more potent analogues

A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B.

Wai-Kay Seto et al.

PloS one, 7(2), e32622-e32622 (2012-03-06)

We determined the association between various clinical parameters and significant liver injury in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients. From 1994 to 2008, liver biopsy was performed on 319 treatment-naïve CHB patients. Histologic assessment was based on

The effect of hydroxychloroquine on haemostasis, complement, inflammation and angiogenesis in patients with antiphospholipid antibodies.

Karen Schreiber et al.

Rheumatology (Oxford, England), 57(1), 120-124 (2017-10-19)

HCQ has been described as having a beneficial effect in patients with APS but its mechanism of action is unclear. We hypothesized that HCQ may have effects on subnormal angiogenesis, inflammation and haemostatic biomarkers seen in APS. The aim of

Clinical profile and frequency of delta f508 mutation in Indian children with cystic fibrosis.

S K Kabra et al.

Indian pediatrics, 40(7), 612-619 (2003-07-26)

To document clinical profile of cystic fibrosis (CF) in Indian children and the prevalence of delta F508 mutation in these patients. Observational study. Pediatric chest clinic in an urban tertiary care center in north India. July 1995 to June 2002.

[The association between polymorphism of the serotonin 2A, 2C receptor genes and obstructive sleep apnea-hypopnea syndrome in Han population].

Jian-Yong Zhu et al.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 30(12), 912-917 (2008-03-14)

To investigate the association between polymorphisms of the serotonin 2A, 2C receptor genes and obstructive sleep apnea-hypopnea syndrome (OSAHS), and therefore to explore the genotypes related to OSAHS. The T102C and A1438G polymorphisms of the serotonin 2A receptor genes and

Dexamethasone measurement during low-dose suppression test for suspected hypercortisolism: threshold development with and validation.

F Ceccato et al.

Journal of endocrinological investigation, 43(8), 1105-1113 (2020-02-16)

Dexamethasone Suppression Test (DST), recommended for Cushing's Syndrome (CS) diagnosis, explores the pituitary feedback to glucocorticoids. Its diagnostic accuracy could be affected by dexamethasone bioavailability, and therefore, we have developed and validated a dexamethasone threshold after 1-mg DST. We studied

Regulation of renal vitamin D hydroxylase activity in vitamin D deficient rats.

M Warner et al.

Canadian journal of physiology and pharmacology, 63(8), 978-982 (1985-08-01)

The regulation of renal mitochondrial 1-hydroxylase activity in chronic vitamin D deficiency was studied in male rats. These rats were born of mothers who had been raised from weaning (21 days) on a vitamin D deficient diet and who had

Trypsin and splanchnic protein turnover during feeding and fasting in human subjects.

Stephen J D O'keefe et al.

American journal of physiology. Gastrointestinal and liver physiology, 290(2), G213-G221 (2005-08-27)

Knowledge of the stimulatory effects of enteral and parenteral (intravenous) feeding on the synthesis and turnover of trypsin would help in the management of acute pancreatitis, because the disease is caused by the premature activation of trypsin. To investigate this

GnRH treatment at artificial insemination in beef cattle fails to increase plasma progesterone concentrations or pregnancy rates.

G A Perry et al.

Theriogenology, 71(5), 775-779 (2008-11-14)

Treatment with GnRH at the onset of standing estrus increased pregnancy percentages and circulating concentrations of progesterone in repeat breeder dairy cows. The objective of this study was to determine the effect of treatment with GnRH at AI on concentrations

Relevance of short-term variation of B-type natriuretic peptide in patients with clinically stable heart failure.

Micha Tobias Maeder et al.

Wiener klinische Wochenschrift, 120(21-22), 672-678 (2009-01-01)

In patients with clinically stable chronic heart failure, circulating B-type natriuretic peptide (BNP) levels may exhibit considerable variation over a period of a few days. The aim of this study was to evaluate the clinical impact of this phenomenon. In

Total renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease.

Glaucia L Veiga et al.

Autonomic neuroscience : basic & clinical, 204, 81-87 (2016-12-10)

It is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in

Cellular stretch increases superoxide production in the thick ascending limb.

Jeffrey L Garvin et al.

Hypertension (Dallas, Tex. : 1979), 51(2), 488-493 (2007-12-26)

Superoxide (O(2)(-)) is an important regulator of kidney function. We have recently shown that luminal flow stimulates O(2)(-) production in the thick ascending limb (TAL), attributable in part to mechanical factors. Stretch, pressure and shear stress all change when flow

Low-Volume Lymph Node Metastases in Endometrial Carcinoma.

Lani K Clinton et al.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 27(6), 1165-1170 (2017-06-13)

The aim of this study was to determine the histopathologic characteristics of patients with endometrial carcinoma with low-volume metastases (micrometastases and isolated tumor cells) compared with macrometastases. We performed a retrospective review of patients with endometrial carcinoma. Among 350 robotic-assisted

Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder.

R D Levitan et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 29(1), 179-186 (2003-10-16)

There is significant evidence that altered dopamine activity plays a role in seasonal affective disorder (SAD). The current study examined three separate genetic hypotheses for SAD related to the 7-repeat allele (7R) of the dopamine-4 receptor gene (DRD4), a variant

Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure.

Shi-Zhu Jin et al.

World journal of gastroenterology, 15(21), 2657-2664 (2009-06-06)

To evaluate the number of bone marrow mononuclear cells (BMMC) that are migrated to the liver following transplantation of murine BMMC into mice with acute liver injury. BMMC were isolated from the bone marrow of mice in a lymphocyte separation

Biogenesis of the secretory granule: chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation.

Coleman A Mosley et al.

Biochemistry, 46(38), 10999-11012 (2007-08-28)

The secretory pro-hormone chromogranin A (CHGA) is densely packed into storage granules along with catecholamines, playing a catalytic role in granule biogenesis. 3-Dimensional structural data on CHGA are lacking. We found a superfamily structural homology for CHGA in the tropomyosin

Effect of feeding peroxidized dried distillers grains with solubles to sows and progeny on growth performance and metabolic oxidative status of nursery pigs.

A R Hanson et al.

Journal of animal science, 93(1), 135-146 (2015-01-09)

This experiment evaluated the effects of including peroxidized corn dried distillers grains with solubles (DDGS) in diets for sows and nursery pigs on growth performance, vitamin E (VE), and Se status, and the incidence of mulberry heart disease (MHD) of

Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial.

Gunter von Minckwitz et al.

The Lancet. Oncology, 15(7), 747-756 (2014-05-06)

Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy

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