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Masatsugu Ueda et al.
Human cell, 22(2), 49-54 (2009-04-22)
A functional T to G germline polymorphism in the promoter region of murine double-minute 2 homolog single nucleotide polymorphism 309 (MDM2-SNP309) has been reported to profoundly accelerate tumor formation, suggesting that it may also represent a powerful cancer predisposing allele.
P B Eisenhauer et al.
Infection and immunity, 60(9), 3556-3565 (1992-09-01)
Paneth cells are specialized small intestine epithelial cells that contain lysozyme, possess phagocytic properties, and secrete cytoplasmic granules into the intestinal crypt lumen after the entry of bacteria. Recent studies by Ouellette and associates (A. J. Ouellette, R. M. Greco
Jiaoyang Yin et al.
Gene, 524(2), 228-231 (2013-04-30)
The pathogenesis of lung cancer in the never-smokers could possibly be different from the one in smokers. PPP1R13L and CD3EAP on chromosome 19q13.3 are mainly involved in apoptosis and transcription. PPP1R13L and CD3EAP variants may be associated with cancer risk.
Klaus Golka et al.
Journal of toxicology and environmental health. Part A, 75(8-10), 572-581 (2012-06-13)
Apart from genetics, nutrition, and environment, occupational factors also play an important role in colon and rectal cancer development. The aim of this study was to examine these cancer types in an area of former coal, iron, and steel industries
K Alagarasu et al.
Journal of clinical immunology, 29(2), 196-204 (2008-08-21)
Vitamin D receptor (VDR) gene polymorphisms in the 5' regulatory region (Cdx2 and A-1012G), coding region (FokI), and 3' untranslated region (UTR; BsmI, ApaI, and TaqI) were studied to find out whether these polymorphisms are associated with susceptibility to or
Pia R Kamstrup et al.
JAMA, 301(22), 2331-2339 (2009-06-11)
High levels of lipoprotein(a) are associated with increased risk of myocardial infarction (MI). To assess whether genetic data are consistent with this association being causal. Three studies of white individuals from Copenhagen, Denmark, were used: the Copenhagen City Heart Study
Dimitry A Chistiakov et al.
Acta diabetologica, 48(3), 227-235 (2011-05-26)
On chromosome 6q22.3, a cluster of single-nucleotide polymorphisms located in intron 5 of the cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 (CDKAL1) gene were shown to confer susceptibility to type 2 diabetes in multiple ethnic groups. The diabetogenic
Neill R Graff-Radford et al.
Archives of neurology, 59(4), 594-600 (2002-04-10)
The association between Alzheimer disease (AD) and genotypes at the apolipoprotein E (APOE) locus has been confirmed in numerous populations worldwide, but appears to be inconsistent in African American subjects. To investigate the association between APOE genotypes and AD in
Ye-Sheng Wei et al.
Clinica chimica acta; international journal of clinical chemistry, 380(1-2), 165-169 (2007-03-21)
Nasopharyngeal cancer (NPC) is multifactorial, and the genetic background may be a crucial etiologic factor. Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine, it promotes tumor growth and metastasis in later stages of phase of cancer development. Variations in the
Hideto Yamada et al.
Journal of gastrointestinal and liver diseases : JGLD, 21(2), 139-143 (2012-06-22)
Histamine plays important physiological roles in upper gastrointestinal tract and acts via the H2 receptor. A polymorphism -1018 G>A (rs2067474) was identified in an enhancer element of the HRH2 promoter. We attempted to clarify the associations of this polymorphism with
Hong-Hu Zhu et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(33), 4215-4221 (2013-10-16)
This randomized, multicenter, phase III noninferiority trial was designed to test the efficacy and safety of an oral tetra-arsenic tetra-sulfide (As4S4) -containing formula named the Realgar-Indigo naturalis formula (RIF) compared with intravenous arsenic trioxide (ATO) as both induction and maintenance
[Correlation of interleukin-13 gene - 1112c/T polymorphism with asthma and total plasma IgE levels].
Bin Wu et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 27(10), 668-671 (2005-10-05)
To investigate the correlation of - 1112C/T polymorphism of Interleukin-13 (IL-13) gene promoter with asthma and its effect on total plasma IgE levels. One hundred asthmatic patients (the asthma group) and 100 healthy controls (the control group) were recruited. Polymerase
Antonio Cuadrado-Lavín et al.
The Journal of antimicrobial chemotherapy, 70(8), 2376-2381 (2015-04-10)
Helicobacter pylori eradication remains a challenge. Non-bismuth-based quadruple regimens (NBQR) have shown high eradication rates (ER) elsewhere that need to be locally confirmed. The objective of this study was to compare the first-line ER of a hybrid therapy (20 mg
Elena Piazuelo et al.
Clinical therapeutics, 30(1), 121-130 (2008-03-18)
Previous studies have reported a potential genetic predisposition to NSAID-related upper gastrointestinal (GI) bleeding. This study evaluated whether there was an association between 2 polymorphisms--the platelet glycoprotein (GP) IIIa PlA1/A2 polymorphism and the 27-bp VNTR (variable number of tandem repeats)
Shuichi Hironaka et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(35), 4438-4444 (2013-11-06)
This phase III study compared treatment with weekly paclitaxel and biweekly irinotecan in patients with advanced gastric cancer refractory to treatment with fluoropyrimidine plus platinum. Patients were randomly assigned to receive either paclitaxel (80 mg/m(2) on days 1, 8, and
Jennifer A Rymer et al.
Journal of the American Heart Association, 8(10), e012236-e012236 (2019-05-10)
Background Although recommended in the guidelines, the safety of chronic P2Y12 inhibitor therapy in patients with chronic kidney disease ( CKD ) after an acute myocardial infarction ( MI ) is not well studied. Methods and Results The TRANSLATE -ACS
Tobias Winkler et al.
Journal of cachexia, sarcopenia and muscle, 9(5), 880-897 (2018-09-20)
No regenerative approach has thus far been shown to be effective in skeletal muscle injuries, despite their high frequency and associated functional deficits. We sought to address surgical trauma-related muscle injuries using local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent
J Sehouli et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 14(10), 1501-1504 (2003-09-25)
Different studies indicate that immunological components play a key role in the development of cancer. Interleukin-1 (IL-1) is known to be critically involved in ovarian carcinogenesis and in other solid tumors. Therefore, we investigated the possible influence of the polymorphism
Jean-Yves Douillard et al.
The New England journal of medicine, 369(11), 1023-1034 (2013-09-13)
Patients with metastatic colorectal cancer that harbors KRAS mutations in exon 2 do not benefit from anti-epidermal growth factor receptor (EGFR) therapy. Other activating RAS mutations may also be negative predictive biomarkers for anti-EGFR therapy. In this prospective-retrospective analysis, we
Dilek Telci et al.
American journal of nephrology, 33(4), 337-343 (2011-03-23)
KLOTHO, a type-1 transmembrane protein with glucurodinase activity, is expressed in tissues responsible for calcium homeostasis such as the kidney, parathyroid gland and the epithelium of the choroid plexus in the brain. Given the emerging evidence indicating a novel regulatory
Shiao-Pei Weathers et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(14), 3565-3577 (2020-04-18)
Cytomegalovirus (CMV) antigens occur in glioblastoma but not in normal brains, making them desirable immunologic targets. Highly functional autologous polyclonal CMV pp65-specific T cells from patients with glioblastoma were numerically expanded under good manufacturing practice compliant conditions and administered after
Ji Hyeon Lee et al.
PloS one, 12(12), e0188925-e0188925 (2017-12-06)
The association between the 6-thioguanine nucleotide (6-TGN) level and clinical remission in Crohn's disease (CD) remains controversial. Thiopurine-induced leukopenia is a life-threatening complication of CD in Asians that was recently shown to strongly correlate with NUDT15 genetic variants. This study
Iraj Saadat et al.
Molecular vision, 18, 1996-2000 (2012-08-10)
To investigate whether genetic polymorphisms of glutathione S-transferases (GSTM1, GSTT1, and GSTO2) in relation to the work place contribute to the development of cataract. The present case-control study consisted of 186 patients (108 females, 78 males) with cataract and 195
Mwiche N P Siame et al.
Malaria journal, 14, 190-190 (2015-05-07)
Sulphadoxine-pyrimethamine (SP) is the recommended drug for intermittent preventive treatment in pregnancy (IPTp) in most African countries, including Zambia. However, malaria is still one of the leading causes of morbidity and mortality in pregnant women despite reports of greater than
David A Halon et al.
JACC. Cardiovascular imaging, 12(7 Pt 2), 1353-1363 (2018-05-21)
The authors used coronary computed tomography angiography (CTA) to determine plaque characteristics predicting individual late plaque events precipitating acute coronary syndromes (ACS) in a cohort of asymptomatic type 2 diabetic patients. In patients with coronary artery disease, CTA plaque characteristics may predict mid-term
Satoshi Ikeda et al.
Acta cytologica, 53(1), 29-35 (2009-03-03)
To investigate immunochemical markers of assisting cytologic diagnosis to evade the inaccuracy to be caused by alteration of urinary samples. We used p53 and epidermal growth factor receptor (EGFR) in an immunostaining cocktail for the differential diagnosis of urine cytology.
Wendy De Roock et al.
The Lancet. Oncology, 11(8), 753-762 (2010-07-14)
Following the discovery that mutant KRAS is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies, the tumours of patients with metastatic colorectal cancer are now profiled for seven KRAS mutations before receiving cetuximab or panitumumab. However, most patients
Saila Lappalainen et al.
Metabolism: clinical and experimental, 58(9), 1263-1269 (2009-06-06)
Premature adrenarche (PA) has been associated with increased body mass index. Our aim was to determine whether the obesity-associated variant at fat mass and obesity gene (FTO) is more frequent in PA subjects. Furthermore, we hypothesized that altered Wnt signaling
Detlef K Bartsch et al.
International journal of cancer, 117(5), 718-722 (2005-06-28)
The RNASEL (encoding ribonuclease L) gene Glu265X mutation has been implicated in familial prostate cancer, and an association between the RNASEL Arg462Gln variant and sporadic and familial prostate cancer, has also been suggested. Because prostate cancer occurs in some familial
Mirjana Novkovic et al.
European journal of clinical pharmacology, 74(4), 443-451 (2017-12-21)
Bleeding is one of the possible adverse events during clopidogrel therapy. The CYP2C19 gene is the most significant genetic factor which influences response to clopidogrel treatment. We aimed to examine the contribution of the CYP2C19 gene to bleeding occurrence during
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