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L Pang et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 26(6), 781-781 (2019-11-02)
In invasive aspergillosis (IA), monitoring response to antifungal treatment is challenging. We aimed to explore if routine blood parameters help to anticipate outcomes following IA. Post hoc secondary analysis of two multicenter randomized trials was performed. The Global Comparative Aspergillosis
Mariela Bernabe-García et al.
Nutrients, 13(2) (2021-03-07)
Necrotizing enterocolitis (NEC) is an inflammatory bowel disease and a leading cause of morbidity and mortality in preterm infants. In this study, a randomized double-blind parallel-group (1:1) trial was carried out in two neonatal intensive care units of two tertiary
Alba M Redondo et al.
British journal of haematology, 184(5), 797-807 (2018-12-15)
We conducted a phase 2 trial to evaluate the safety and efficacy of bendamustine instead of BCNU (carmustine) in the BEAM (BCNU, etoposide, cytarabine and melphalan) regimen (BendaEAM) as conditioning for autologous stem-cell transplantation (ASCT) in patients with aggressive lymphomas.
Giovanna Crisante et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(11), 4792-4805 (2014-08-21)
Serine proteases, serine protease inhibitors, and protease-activated receptors (PARs) are responsible for several human skin disorders characterized by impaired epidermal permeability barrier function, desquamation, and inflammation. In this study, we addressed the consequences of a catalytically dead serine protease on
Brian R McMinn et al.
Journal of virological methods, 179(2), 423-428 (2011-12-06)
The effective recovery of adenovirus from water is a critical first step in developing a virus occurrence method able to provide accurate data for risk assessments and other applications. During virus concentration, electropositive filters are typically eluted with beef extract
Baris Gencer et al.
Atherosclerosis, 239(1), 118-124 (2015-01-15)
2013 AHA/ACC guidelines on the treatment of cholesterol advised to tailor high-intensity statin after ACS, while previous ATP-III recommended titration of statin to reach low-density lipoprotein cholesterol (LDL-C) targets. We simulated the impact of this change of paradigm on the
Qingnan Liu et al.
The journal of physical chemistry. A, 113(16), 4387-4396 (2009-03-24)
Collision rates and energy transfer distributions are reported for HOD with highly vibrationally excited 2-methylpyridine (2-picoline, E = 38 310 cm(-1)) and 2,6-dimethylpyridine (2,6-lutidine, E = 38 700 cm(-1)). High resolution transient IR absorption is used measured to complete product
V V Pauk et al.
Molekuliarnaia biologiia, 41(4), 601-607 (2007-10-17)
Comparison in genotype and allele frequencies of people groups of younger (from 1 till 20 years), middle (21-55 years), elderly (56-74 years), senile (75-89 years) age and long-livers (90-109 years) have been performed (only 1116 person) with the purpose of
C B Eap et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 802(2), 339-345 (2004-03-17)
Midazolam is a widely accepted probe for phenotyping cytochrome P4503A. A gas chromatography-mass spectrometry (GC-MS)-negative chemical ionization method is presented which allows measuring very low levels of midazolam (MID), 1-OH midazolam (1OHMID) and 4-OH midazolam (4OHMID), in plasma, after derivatization
Marianne O Larsen et al.
American journal of physiology. Endocrinology and metabolism, 282(6), E1342-E1351 (2002-05-15)
Nonrodent models of diabetes are needed for practical and physiological reasons. Induction of mild insulin-deficient diabetes was investigated in male Göttingen minipigs by use of streptozotocin (STZ) alone (75, 100, and 125 mg/kg) or 125 mg/kg combined with pretreatment with
R Holm et al.
Journal of clinical pathology, 61(1), 59-63 (2007-05-01)
To determine the levels of expression of ZNF652 and its relevance to prognosis in vulvar squamous cell carcinomas. 22 cases of vulvar intraepithelial neoplasia (VIN) and tumours from 217 patients with vulvar squamous cell carcinomas were investigated for expression of
Lifen Yan et al.
Se pu = Chinese journal of chromatography, 32(12), 1295-1300 (2015-04-24)
A novel solid-phase microextraction fiber was prepared via simple adhesion process. Fused-silica fiber was used as supporting substrate and the cucurbit[7] uril/Eu coordination polymers induced by [CdCl4]2- anion was affixed onto the surface of fused-silica fiber with high-temperature epoxy resin
Morten Würtz et al.
International journal of cardiology, 175(2), 274-279 (2014-05-28)
Once-daily aspirin is standard treatment, but recent studies point towards increased platelet function at the end of the dosing interval. Stent thrombosis (ST) has been linked with reduced antiplatelet effect of aspirin, so we investigated if platelet inhibition by aspirin
Brahim El Houate et al.
The Journal of urology, 177(5), 1947-1951 (2007-04-18)
Cryptorchidism affects 1% to 9% of full-term male neonates. Hypospadias is the second most frequent congenital anomaly seen in newborn males. These pathological conditions are part of the testicular dysgenesis syndrome. Insulin-like factor 3 and LGR8 (leucine-rich repeat-containing G protein-coupled
Sébastien Albert et al.
European journal of human genetics : EJHG, 14(6), 773-779 (2006-03-30)
Sensorineural hearing loss is the most frequent sensory deficit of childhood and is of genetic origin in up to 75% of cases. It has been shown that mutations of the SLC26A4 (PDS) gene were involved in syndromic deafness characterized by
J Hall et al.
The Journal of biological chemistry, 262(23), 11046-11051 (1987-08-15)
In order to define the interaction domain on Rhodospirillum rubrum cytochrome c2 for the photosynthetic reaction center, positively charged lysine amino groups on cytochrome c2 were modified to form negatively charged carboxydinitrophenyl lysines. The reaction mixture was separated into six
Jamie N Bakkum-Gamez et al.
Gynecologic oncology, 108(1), 141-148 (2007-11-09)
Müllerian inhibiting substance type II receptor (MISIIR) is expressed by ovarian, breast, and prostate cancers [Masiakos PT, et al. Human ovarian cancer, cell lines, and primary ascites cells express the human Mullerian inhibiting substance (MIS) Type II Receptor, bind, and
Anna B Roehl et al.
BMC neurology, 12, 81-81 (2012-08-28)
Neuroprotective strategies after cardiopulmonary resuscitation are currently the focus of experimental and clinical research. Levosimendan has been proposed as a promising drug candidate because of its cardioprotective properties, improved haemodynamic effects in vivo and reduced traumatic brain injury in vitro.
J Marín et al.
British journal of pharmacology, 124(3), 473-478 (1998-07-01)
1. The aim of the present study was to explore the contribution of adrenergic, sensory and nitrergic innervations to the inhibitory effects of the beta2-adrenoceptor agonist clenbuterol on responses to electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz
Lionel D Lewis et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(11), 3302-3311 (2007-06-05)
Increased clearance of drugs, such as oral cyclosporine, that are CYP3A and/or ABCB1 (P-gp/MDR1) substrates was reported in African-American compared with Caucasian patients. We hypothesized that the pharmacokinetics and pharmacodynamics of docetaxel, an i.v. administered cytotoxic and substrate for CYP3A4
Carrie E Gifford et al.
Cytometry. Part B, Clinical cytometry, 86(4), 263-271 (2014-03-13)
X-linked lymphoproliferative disease is caused by mutations in two genes, SH2D1A and XIAP/BIRC4. Flow cytometric methods have been developed to detect the gene products, SAP and XIAP. However, there is no literature describing the accuracy of flow cytometric screening performed
Kristian B Buhl et al.
Hypertension (Dallas, Tex. : 1979), 60(5), 1346-1351 (2012-09-19)
In nephrotic syndrome, plasminogen is aberrantly filtered from plasma to the urinary space and activated along the tubular system. In vitro, plasmin increases ENaC current by proteolytic cleavage of the γ-subunit. It was hypothesized that preeclampsia is associated with plasmin-dependent
D Steinberg
Revista espanola de anestesiologia y reanimacion, 56(10), 604-611 (2010-02-16)
The correlation between gender and the potency of certain neuromuscular blockers, including rocuronium, has been investigated. However, the methods used have been inconsistent. This study aimed to look further at the role of gender in order to arrive at definitive
Howard Trachtman et al.
Journal of the American Society of Nephrology : JASN, 29(11), 2745-2754 (2018-10-27)
We evaluated and compared the effects of sparsentan, a dual endothelin type A (ETA) and angiotensin II type 1 receptor antagonist, with those of the angiotensin II type 1 receptor antagonist irbesartan in patients with primary FSGS. In this phase
D Stanislaus et al.
Endocrinology, 139(6), 2710-2717 (1998-06-02)
In this study, we used mice lacking the G11alpha [G11 knockout (KO)] or Gqalpha gene (Gq KO) to examine LH release in response to a metabolically stable GnRH agonist (Buserelin). Mice homozygous for the absence of G11alpha and Gqalpha appear
Dominik Braun et al.
Frontiers in chemistry, 8, 423-423 (2020-06-09)
Exposure to natural food contaminants during infancy may influence health consequences later in life. Hence, breast milk may serve as a vehicle to transport these contaminants, including mycotoxins, from mothers to their infants. Analytical methods mostly focused on single exposures
Stephan Gruber et al.
Investigative radiology, 52(10), 631-639 (2017-05-02)
The aim of this study was to compare high-resolution free induction decay magnetic resonance spectroscopic imaging (FID-MRSI) at 3 T and 7 T in the brain of healthy subjects and to showcase the clinical potential of accelerated FID-MRSI at 7
Sergi Veloso et al.
BMC medical genetics, 11, 63-63 (2010-04-28)
Tumor necrosis factor alpha (TNF-alpha) is thought to be involved in the various immunogenetic events that influence HIV-1 infection. We aimed to determine whether carriage of the TNF-alpha-238G>A, -308G>A and -863 C>A gene promoter single nucleotide polymorphisms (SNP) and the
Daniel P Petrylak et al.
The Lancet. Oncology, 16(4), 417-425 (2015-03-07)
Patients with metastatic castration-resistant prostate cancer have few treatment options. We investigated the safety and efficacy of lenalidomide, an immunomodulatory agent with anti-angiogenic properties, in combination with docetaxel and prednisone in chemotherapy-naive patients with metastatic castration-resistant prostate cancer. In this
The Lancet. Neurology, 14(1), 39-47 (2014-12-04)
PBT2 is a metal protein-attenuating compound that might reduce metal-induced aggregation of mutant huntingtin and has prolonged survival in a mouse model of Huntington's disease. We aimed to assess the safety, tolerability, and efficacy of PBT2 in patients with Huntington's
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