110-75-8

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Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.

James M Bullock et al.

Neurobiology of aging, 34(4), 1309-1309 (2012-10-06)

Despite recent discoveries in the genetics of sporadic Alzheimer's disease, there remains substantial "hidden heritability." It is thought that some of this missing heritability may be because of gene-gene, i.e., epistatic, interactions. We examined potential epistasis between 110 candidate polymorphisms

A naturalistic evaluation and audit database of agomelatine: clinical outcome at 12 weeks.

A Sparshatt et al.

Acta psychiatrica Scandinavica, 128(3), 203-211 (2012-12-18)

To determine the effectiveness of agomelatine in routine clinical practice and explore factors associated with response and continuation. Consecutive patients prescribed agomelatine in participating psychiatric services were included. Patient demographic and outcome data were collected at treatment initiation and then

The consequence of nucleotide substitutions in the triosephosphate isomerase (TPI) gene promoter.

A Humphries et al.

Blood cells, molecules & diseases, 25(3-4), 210-217 (1999-11-27)

Mutations at -5A-->G, -8-->GA within the cap proximal element (CPE), and -24T-->G within the TATA box of the triosephosphate isomerase (TPI) gene promoter have been identified in populations with a wide geographical distribution. These mutations lie within, or in close

Genetic heterogeneity of beta-thalassemia at Cukurova in southern Turkey.

M A Cürük et al.

Hemoglobin, 25(2), 241-245 (2001-08-02)

Beta-thalassemia is the most common genetic abnormality causing health problems worldwide. Cukurova, in the southern part of Turkey, being on the Mediterranean, is in the thalassemic belt. Since there is no cure for the disease at present, the frequency of

Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas.

Markus Vogt et al.

Virchows Archiv : an international journal of pathology, 458(3), 313-322 (2011-01-13)

The microRNA encoding genes miR-34a and miR-34b/c represent direct p53 target genes and possess tumor suppressive properties as they mediate apoptosis, cell cycle arrest, and senescence. We previously reported that the miR-34a gene is subject to epigenetic inactivation by CpG

Population-based newborn screening for genetic disorders when multiple mutation DNA testing is incorporated: a cystic fibrosis newborn screening model demonstrating increased sensitivity but more carrier detections.

Anne Marie Comeau et al.

Pediatrics, 113(6), 1573-1581 (2004-06-03)

Newborn screening for cystic fibrosis (CF) provides a model to investigate the implications of applying multiple-mutation DNA testing in screening for any disorder in a pediatric population-based setting, where detection of affected infants is desired and identification of unaffected carriers

Elevation of expression of Smads 2, 3, and 4, decorin and TGF-beta in the chronic phase of myocardial infarct scar healing.

J Hao et al.

Journal of molecular and cellular cardiology, 31(3), 667-678 (1999-04-13)

We have previously shown that non-myocytes present in healed 8-week infarct scar overexpress transduction proteins required for initiating the elevated deposition of structural matrix proteins in this tissue. Other work suggests that TGF-beta 1 may be involved in cardiac fibrosis

Herbal preparation extract for skin after radiotherapy treatment. Part One--Preclinical tests.

Agnieszka Skalska-Kamińska et al.

Acta poloniae pharmaceutica, 71(5), 781-788 (2014-11-05)

Naran R is a herbal composition made of Plantago lanceolate folium, Malvae arboreae flos, Calendulae flos, Chamomillae inflorescentia, Lamii albi flos to prepare compresses or to wash skin with inflammations. The extract of this preparation is mixed to be applied

Safety and efficacy of exercise training in adults with Pompe disease: evalution of endurance, muscle strength and core stability before and after a 12 week training program.

Linda E M van den Berg et al.

Orphanet journal of rare diseases, 10, 87-87 (2015-07-19)

Pompe disease is a proximal myopathy. We investigated whether exercise training is a safe and useful adjuvant therapy for adult Pompe patients, receiving enzyme replacement therapy. Training comprised 36 sessions of standardized aerobic, resistance and core stability exercises over 12

Assessment of indications for percutaneous endoscopic gastrostomy--development of a predictive model.

Marianne Udd et al.

Scandinavian journal of gastroenterology, 50(2), 245-252 (2014-12-30)

Percutaneous endoscopic gastrostomy (PEG) is used for long-term enteral nutrition in neurological patients with dysphagia (NEUR), in head and neck cancer patients prior to chemoradiation therapy (head and neck malignancy group [HNM]), or in cases of oropharyngeal or esophageal tumor

Simultaneous determination of ethidimuron, methabenzthiazuron, and their two major degradation products in soil.

Florence Lagarde et al.

Journal of agricultural and food chemistry, 54(20), 7450-7459 (2006-09-28)

An analytical method has been developed for the quantification of two herbicides (ethidimuron and methabenzthiazuron) and their two main soil derivatives. This method involves fluidized-bed extraction (FBE) prior to cleanup and analysis by reverse-phase liquid chromatography with UV detection at

[Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial].

Xiao-li Wang et al.

Zhonghua xin xue guan bing za zhi, 34(4), 338-340 (2006-06-17)

To compare the safety and efficacy of midazolam and estazolam in hypertensive patients with chronic insomnia. In this multicentre, open labeled, randomized clinical trial, 217 adult (18 - 75 years) hypertensive patients (BP range 140 mm Hg <or= SBP <

Cytokeratin-19 and mammaglobin gene expression in circulating tumor cells from metastatic breast cancer patients enrolled in North Central Cancer Treatment Group trials, N0234/336/436/437.

Monica M Reinholz et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 17(22), 7183-7193 (2011-10-07)

To investigate the associations between baseline and posttreatment circulating tumor cell (CTC) gene expression and outcome of patients enrolled in four North Central Cancer Treatment Group metastatic breast cancer (MBC) trials in which specimens were shipped (at 4°C) from community-based

Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers.

Mathewos Tessema et al.

Carcinogenesis, 35(6), 1248-1257 (2014-01-09)

Lung cancer in never smokers (NS) shows striking demographic, clinicopathological and molecular distinctions from the disease in smokers (S). Studies on selected genetic and epigenetic alterations in lung cancer identified that the frequency and profile of some abnormalities significantly differ

IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: role in the course of chronic viral hepatitis and the development of HCC.

Carlo Fabris et al.

Journal of hepatology, 54(4), 716-722 (2010-12-15)

A single nucleotide polymorphism (rs12979860 C/T) 3kb upstream of the interleukin 28B (IL-28B) gene was shown to be associated with hepatitis C clearance. We verified whether this association also translates into a different genotype distribution at the end of the

High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas.

Zahra Madjd et al.

Breast cancer research : BCR, 7(5), R780-R787 (2005-09-20)

There is sufficient evidence that blood group related Lewis antigens are tumour-associated molecules. The Lewisy and Lewisb antigens are complex carbohydrates that are over-expressed by breast, lung, colon and ovarian cancers. The SC101 mAb is a unique Lewisy/b binding antibody

Combining insulin-like growth factor derivatives plus caffeinol produces robust neuroprotection after stroke in rats.

Xiurong Zhao et al.

Stroke, 36(1), 129-134 (2004-12-01)

Insulin-like growth factor-1 (IGF-1) and caffeinol are both neuroprotective and probably have different mechanisms of action; therefore, they may be more effective in combination. We tested the N-terminal tripeptide of IGF-1, Gly-Pro-Glu (GPE), and its analogue, G2MePE, alone and with

Influence of the alpha-adducin and ACE gene polymorphism on the progression of autosomal-dominant polycystic kidney disease.

M Merta et al.

Kidney & blood pressure research, 26(1), 42-49 (2003-04-17)

A significant phenotypical variability is observed in autosomal dominant polycystic kidney disease (ADPKD). The variability can not be fully explained by the genetic heterogeneity of the disease. We examined the influence of the ACE I/D polymorphism, adducin Trp460Gly polymorphism and

Effect of infarct severity on regional and global left ventricular remodeling in patients with successfully reperfused ST segment elevation myocardial infarction.

Rolf Symons et al.

Radiology, 274(1), 93-102 (2014-09-11)

To evaluate the relationship between myocardial infarction ( MI myocardial infarction ) severity at magnetic resonance (MR) imaging and regional and global postinfarction left ventricular ( LV left ventricular ) remodeling. This HIPAA-compliant study was institutional review board approved. In

Off-the-Shelf Devices for Treatment of Thoracic Aortic Diseases: Midterm Follow-up of TEVAR With Chimneys or Physician-Made Fenestrations.

Lei Zhang et al.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 27(1), 132-142 (2019-12-04)

Purpose: To evaluate the midterm outcomes of thoracic endovascular aortic repair (TEVAR) using chimney grafts (ch-TEVAR) or thoracic stent-grafts with fenestrations made on the back table (f-TEVAR) to treat thoracic aortic dissection (TAD) and thoracic aortic aneurysm (TAA). Materials and

cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase.

T Suzuki et al.

The Journal of biological chemistry, 274(1), 241-248 (1998-12-29)

Prostaglandin (PG) F synthase catalyzes the reduction of PGD2 to 9alpha,11beta-PGF2 and that of PGH2 to PGF2alpha on the same molecule. PGF synthase has at least two isoforms, the lung-type enzyme (Km value of 120 microM for PGD2 (Watanabe, K.

The use of MElatonin in children with neurodevelopmental disorders and impaired sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS).

R E Appleton et al.

Health technology assessment (Winchester, England), 16(40), i-239 (2012-10-27)

Difficulties in initiating and maintaining sleep are common in children with neurodevelopmental disorders. Melatonin is unlicensed in children yet widely prescribed for sleep problems. To determine whether or not immediate-release melatonin is beneficial compared with placebo in improving total duration

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