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Cecilia M M Motta et al.
Biomaterials, 218, 119335-119335 (2019-07-16)
Neuroregeneration following peripheral nerve injury is largely mediated by Schwann cells (SC), the principal glial cell that supports neurons in the peripheral nervous system. Axonal regeneration in vivo is limited by the extent of SC migration into the gap between
Joong-Hyun Kim et al.
Journal of biomedical materials research. Part A, 106(1), 115-125 (2017-09-08)
Insufficient repair of the bone-to-tendon interface (BTI) with structural/compositional gradients has been a significant challenge in orthopedics. In this study, dual growth factor (platelet-derived growth factor-BB [PDGF-BB] and bone morphogenetic protein-2 [BMP-2])-immobilized polycaprolactone (PCL)/Pluronic F127 asymmetrically porous membrane was fabricated
Stanisław Popiel et al.
Analytica chimica acta, 837, 52-63 (2014-07-09)
Novel solid-phase microextraction (SPME) fibres containing methyl, ethyl, butyl acrylate and methacrylate were first prepared by a sol-gel technique and investigated for determination of selected organoarsenic compounds (lewisite, methyldichloroarsine, phenyldichloroarsine, diphenylchloroarsine and triphenylarsine) from water samples. The influence of sorption
Rieko Asai et al.
Scientific reports, 7(1), 8955-8955 (2017-08-23)
The somatopleure is the amniotic primordium in amniote development, but its boundary to the embryonic body at early embryonic stages and the fate of cells constituting this structure are not well characterized. It also remains unclear how cells behave during
Bi-Yuan Zheng et al.
European journal of medicinal chemistry, 155, 24-33 (2018-06-01)
A series of novel symmetric or unsymmetric silicon (IV) phthalocyanines axially substituted with cyclic Arg-Gly-Asp (cRGD) ligands through different ethylene glycol chains have been synthesized by a facile and mild "click" reaction. All the compounds show efficient photosensitizing activities in
Xi Wang et al.
Dalton transactions (Cambridge, England : 2003), 47(27), 9096-9102 (2018-06-26)
A one-pot hydrothermal approach has been developed to introduce tetraethylene glycol (TEG) molecules into a two-dimensional (2D) layered lanthanide metal-organic framework ([Sm(H5C2P2O7)(H2O)2]·Guest, denoted SmHEDP-Guest). Through the straightforward loading of TEG, the proton conductivity of SmHEDP-TEG (1.21 × 10-3 S cm-1)
Abdelmoneim Mars et al.
Mikrochimica acta, 185(10), 449-449 (2018-09-09)
The authors describe a method for electrochemical determination of the breast cancer biomarker α-lactalbumin (α-LA) using disposable screen-printed carbon electrodes (SPCEs). Lysozyme-conjugated Fe3O4 nanoparticles (Lys-Fe3O4NPs) were used to capture α-LA on the surface of the SPCEs which then is trapped
Giuseppe Antonio Elia et al.
Scientific reports, 5, 12307-12307 (2015-08-05)
Herein we report the characteristics of a lithium-oxygen battery using a solid polymer membrane as the electrolyte separator. The polymer electrolyte, fully characterized in terms of electrochemical properties, shows suitable conductivity at room temperature allowing the reversible cycling of the
Anjali Sharma et al.
Science advances, 6(4), eaay8514-eaay8514 (2020-02-06)
Poor transport of neuropharmaceutics through central nervous system (CNS) barriers limits the development of effective treatments for CNS disorders. We present the facile synthesis of a novel neuroinflammation-targeting polyethylene glycol-based dendrimer (PEGOL-60) using an efficient click chemistry approach. PEGOL-60 reduces
Dong Woo Yeom et al.
International journal of nanomedicine, 10, 3865-3877 (2015-06-20)
In this study, we developed and optimized a self-microemulsifying drug delivery system (SMEDDS) formulation for improving the dissolution and oral absorption of atorvastatin calcium (ATV), a poorly water-soluble drug. Solubility and emulsification tests were performed to select a suitable combination
Nobuko Hada et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 102, 46-54 (2017-02-28)
The delivery of drugs to the brain is a constant challenge due to limitations imposed by the blood-brain barrier (BBB). Various methods of bypassing the BBB are under investigation. One approach is intranasal administration, where the olfactory region of the
Harumi Kaga et al.
Molecules (Basel, Switzerland), 25(8) (2020-04-26)
The microwave-assisted heating reaction of N-acetyl glucosamine (GlcNAc) in sulfolane is described. The reaction produces two major products that are assignable to 1,6-anhydro-2-acetamido-2-deoxy-β-d-glucopyranose (AGPNAc) and 1,6-anhydro-2-acetamido-2-deoxy-β-d-glucofuranose (AGFNAc). In order to reveal a general feature of the system, the 3, 5
Matus E Diveky et al.
Physical chemistry chemical physics : PCCP, 21(9), 4721-4731 (2018-12-20)
Photoacoustic spectroscopy is widely used to measure the light absorption of aerosols. However, the impact of key factors such as the effect of relative humidity and mass exchange on photoacoustic measurements are still poorly understood. We assess such measurement biases
Boitumelo J Matsoso et al.
Nanomaterials (Basel, Switzerland), 10(3) (2020-03-04)
Hexagonal boron nitrite (hBN) is an attractive material for many applications such as in electronics as a complement to graphene, in anti-oxidation coatings, light emitters, etc. However, the synthesis of high-quality hBN at cost-effective conditions is still a great challenge.
Mohamed Basel Bazbouz et al.
Sensors (Basel, Switzerland), 19(5) (2019-03-01)
The spread of antimicrobial resistance calls for chronic wound management devices that can engage with the wound exudate and signal infection by prompt visual effects. Here, the manufacture of a two-layer fibrous device with independently-controlled exudate management capability and visual
Rachel E Whitmire et al.
Biomaterials, 33(30), 7665-7675 (2012-07-24)
Intra-articular delivery of therapeutics to modulate osteoarthritis (OA) is challenging. Delivery of interleukin-1 receptor antagonist (IL-1Ra), the natural protein inhibitor of IL-1, to modulate IL-1-based inflammation through gene therapy or bolus protein injections has emerged as a promising therapy for
Doh Young Lee et al.
Biomaterials, 44, 134-142 (2015-01-27)
Although several studies have been successfully undertaken of tracheal reconstruction in terms of the maintaining the framework of the graft, most cases of reconstruction failure have resulted from delayed mucosal regeneration. The purposes of this study were to evaluate whether
Marta Worzakowska
Molecules (Basel, Switzerland), 20(6), 10594-10603 (2015-06-11)
Cinnamyl long chain aroma esters were prepared by using the conventional and microwave-assisted methods. The esterification reaction of naturally occurring 3-phenyl-prop-2-en-1-ol and different chain lengths acidic and diol reagents was carried out at the temperature of 140 °C under solvent
Yang Li et al.
The journal of physical chemistry letters, 8(17), 4218-4225 (2017-08-22)
Redox mediators (RMs) have been widely applied to reduce the charge overpotential of nonaqueous lithium-oxygen (Li-O
Imran Nazir et al.
International journal of pharmaceutics, 561, 197-205 (2019-03-06)
The aim of this study was to evaluate the impact of stability of hydrophobic ion pairs (HIPs) in gastrointestinal (GI) fluids on their release from self-emulsifying drug delivery systems (SEDDS). HIPs of leuprolide (LEU), insulin (INS) and bovine serum albumin
Rahul A Patil et al.
Analytical and bioanalytical chemistry, 410(19), 4645-4655 (2018-01-31)
The rapid expansion in the study and use of ionic liquids (ILs) is a result of their unique properties including negligible volatility, high thermal stability, and ability to dissolve disparate compounds. However, because ILs have infinitely variable structures (often referred
Kurinji Krishnamoorthy et al.
ACS nano, 13(10), 11382-11391 (2019-09-13)
Label-free in situ X-ray scattering from protein spherical nucleic acids (Pro-SNAs, consisting of protein cores densely functionalized with covalently bound DNA) was used to elucidate the enzymatic reaction pathway for the DNase I-induced degradation of DNA. Time-course small-angle X-ray scattering
Mary Caldorera-Moore et al.
Journal of drug targeting, 27(5-6), 582-589 (2018-11-21)
Whereas significant advancements have been made in our fundamental understanding of cancer, they have not yet translated into effective clinical cancer treatments. One of the areas that has the potential to improve the efficacy of cancer therapies is the development
Vanitha Venkoba Rao et al.
Journal of cellular biochemistry (2019-02-13)
Akirin1 is a highly conserved ubiquitously expressed nuclear protein. Owing to its strong nuclear localization signal and protein-protein interaction properties, Akirin1 has been speculated to regulate transcription of target genes as a cofactor. Previous studies have reported Akirin1 as a
Bhawana Pandey et al.
Bioconjugate chemistry, 30(3), 633-646 (2018-12-29)
Glycopolypeptide-based nanocarriers are an attractive class of drug delivery vehicles because of the involvement of carbohydrates in the receptor-mediated endocytosis process. To enhance their efficacy toward controlled and programmable drug delivery, we have prepared stable glycopolypeptide-based bioactive dual-stimuli-responsive (redox and
Leslie S Hamachi et al.
Chemical science, 10(26), 6539-6552 (2019-08-02)
We report a method to control the composition and microstructure of CdSe1-x S x
Michael C Koetting et al.
International journal of pharmaceutics, 471(1-2), 83-91 (2014-05-24)
pH-Responsive hydrogels comprised of itaconic acid copolymerized with N-vinylpyrrolidone (P(IA-co-NVP)) were synthesized and tested as carriers for the oral delivery of high isoelectric point (pI) exhibiting therapeutic proteins. Swelling studies show that P(IA-co-NVP) hydrogels exhibit significantly greater and faster pH-responsive
Aijaz Ahmad Dar et al.
Physical chemistry chemical physics : PCCP, 19(35), 23747-23761 (2017-06-20)
A delicate balance-of-forces governs the interactions responsible for surfactant self-assembly and chemical reactivity within them. Chemical reactions in micellar media generally occur in the interfacial region of micelles that is a complex mixture of: water, headgroups, counterions, co-ions, acids or
Nuria Navarrete et al.
Scientific reports, 7(1), 17580-17580 (2017-12-16)
Nanofluids using nanoencapsulated Phase Change Materials (nePCM) allow increments in both the thermal conductivity and heat capacity of the base fluid. Incremented heat capacity is produced by the melting enthalpy of the nanoparticles core. In this work two important advances
Klara Altintoprak et al.
Beilstein journal of nanotechnology, 6, 1399-1412 (2015-07-23)
The coating of regular-shaped, readily available nanorod biotemplates with inorganic compounds has attracted increasing interest during recent years. The goal is an effective, bioinspired fabrication of fiber-reinforced composites and robust, miniaturized technical devices. Major challenges in the synthesis of applicable
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