111-01-3

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Differences in genotype and allele frequency distributions of polymorphic drug metabolizing enzymes CYP2C19 and CYP2D6 in mainland Chinese Mongolian, Hui and Han populations.

S-J Yin et al.

Journal of clinical pharmacy and therapeutics, 37(3), 364-369 (2011-09-15)

Cytochrome P450 2C19 (CYP2C19) and CYP2D6 are important xenobiotic metabolic enzymes and both show considerable genetic variability between Orientals and Caucasians. There are known marked heterogeneity in susceptibility to various cancers and hypertension among Chinese Mongolian, Hui and Han ethnic

Efficacy of intensive chemotherapy for acute myelogenous leukemia associated with a preleukemic syndrome.

J L Gajewski et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 7(11), 1637-1645 (1989-11-01)

One hundred ninety-six patients with acute myelogenous leukemia (AML) were treated with intensive induction chemotherapy using similar daunorubicin/cytarabine/thioguanine regimens. Treatment results of 44 patients who had a documented preleukemic syndrome or cytopenia present for more than 2 months before developing

Porphyromonas gingivalis in the tongue biofilm is associated with clinical outcome in rheumatoid arthritis patients.

F Ceccarelli et al.

Clinical and experimental immunology, 194(2), 244-252 (2018-07-17)

Several studies have suggested a link between human microbiome and rheumatoid arthritis (RA) development. Porphyromonas gingivalis seems involved in RA initiation and progression, as supported by the high occurrence of periodontitis. In this case-control study, we analysed tongue P. gingivalis

Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis.

Nezam Haider et al.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 16(5), 753-762 (2009-08-08)

Macrophage apoptosis and MMP activity contribute to vulnerability of atherosclerotic plaques to rupture. By employing molecular imaging techniques, we investigated if apoptosis and MMP release are interlinked. Atherosclerosis was produced in rabbits receiving high-cholesterol diet (HC), who underwent dual radionuclide

Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene.

P Madeddu et al.

Circulation, 96(10), 3570-3578 (1997-12-13)

To evaluate the role of kinins in the regulation of cardiovascular function, we studied the phenotype of a mouse strain with disruption of the bradykinin B2-receptor gene (Bk 2r-/-). Under basal conditions, tail-cuff blood pressure was higher in Bk2r-/- than

COMT Val158Met Polymorphism and Symptom Improvement Following a Cognitively Focused Intervention for Irritable Bowel Syndrome.

Claire J Han et al.

Nursing research, 66(2), 75-84 (2017-03-03)

Our nurse-delivered comprehensive self-management (CSM) program, a cognitive behavioral therapy intervention, is effective in reducing gastrointestinal and psychological distress symptoms in patients with irritable bowel syndrome (IBS). Findings from non-IBS studies indicate that the catechol-O-methyltransferase (COMT) Val158Met polymorphism may moderate

Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial.

D Nicholas Bateman et al.

Lancet (London, England), 383(9918), 697-704 (2013-12-03)

Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent adverse effects related to concentration, which can cause treatment interruption. We aimed to ascertain whether adverse effects could be

Delivering the Thinking Healthy Programme for perinatal depression through peers: an individually randomised controlled trial in India.

Daniela C Fuhr et al.

The lancet. Psychiatry, 6(2), 115-127 (2019-01-29)

The Thinking Healthy Programme (THP) is a psychological intervention recommended for the treatment of perinatal depression. However, efforts to integrate the intervention at scale into the routines of community health workers who delivered the THP when it was first evaluated

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