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Danny L Costantini et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 51(7), 1084-1091 (2010-06-18)
(111)In-nuclear localization sequence-trastuzumab is a radioimmunotherapeutic agent consisting of trastuzumab modified with NLS peptides (CGYGPKKKRKVGG) and labeled with the Auger electron emitter (111)In. Our objectives were to evaluate the tumor growth-inhibitory properties and normal-tissue toxicity of (111)In-NLS-trastuzumab in mice after
Y Zheng et al.
Carcinogenesis, 22(12), 2005-2008 (2001-12-26)
Checkpoint kinase 2 (hCHK2/hCds1) is a tumor suppressor gene involved in cell-cycle control. A hCHK2/hCds1 polymorphism in codon 84 (A-->G at nucleotide 252) was recently identified in Li-Fraumeni syndrome patients. Because cell cycle regulates DNA repair that is associated with
Loes Van Keimpema et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(1), 92-98 (2010-04-23)
Isolated polycystic liver disease (PCLD) is characterized by the presence of multiple cysts in the liver in the absence of polycystic kidneys. The clinical profile of PCLD is poorly defined and we set up a study for the clinical characteristics
N Koyanagi et al.
Cancer research, 54(7), 1702-1706 (1994-04-01)
The search for compounds active against solid tumors has led us to the discovery of a novel sulfonamide, E7010 (N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4- methoxybenzenesulfonamide), which inhibits tubulin polymerization. When administered orally, E7010 showed good antitumor activity against various rodent tumors and human tumor
Richard C Bell et al.
The Journal of chemical physics, 127(2), 024704-024704 (2007-07-21)
An ion soft-landing approach was applied to study the motion of hydronium (D(3)O(+)) and cesium (Cs(+)) ions from 84 to 104 K in glassy 3-methyl-pentane (3MP) films vapor deposited on Pt(111). Both ions were found to have very similar mobilities
Iraj Saadat et al.
Molecular vision, 18, 1996-2000 (2012-08-10)
To investigate whether genetic polymorphisms of glutathione S-transferases (GSTM1, GSTT1, and GSTO2) in relation to the work place contribute to the development of cataract. The present case-control study consisted of 186 patients (108 females, 78 males) with cataract and 195
P. Askerlund
Plant physiology, 110(3), 913-922 (1996-03-01)
The effect of controlled trypsin digestion of a calmodulin-stimulated Ca2+-ATPase in low-density intracellular membranes from cauliflower (Brassica oleracea L.) inflorescences was investigated. Ca2+ uptake into vesicles was measured either continuously with the fluorescent Ca2+ indicator Calcium Green-5N or with a
F Lozano et al.
Tissue antigens, 66(2), 131-135 (2005-07-21)
The lectin pathway of the complement system is activated when mannan-binding lectin (MBL) in complex with MBL-associated serine protease 2 (MASP-2) binds to carbohydrate structures on microorganisms. Structural gene mutations and promoter polymorphisms in the MBL2 gene responsible for low-MBL
J Alvarez Sabín et al.
Revista de neurologia, 27(160), 951-955 (1999-02-10)
Different studies have shown that aspirin (AAS), in low doses, may lead to a considerable frequency of hemorrhagic complications when used in the long term. We compare the long-term occurrence of hemorrhagic complications with low doses of AAS and high
Jianyou Gu et al.
Veterinary immunology and immunopathology, 134(3-4), 230-238 (2009-11-20)
Interleukin 2 (IL-2) is an essential cytokine that plays a pivotal role in the replication, maturation and differentiation of lymphocytes. In this study, the functional domains of chicken IL-2 (chIL-2) were mapped with monoclonal antibodies (mAb), a synthetic peptide, and
Jacqueline M Vaughn et al.
Microbial pathogenesis, 144, 104171-104171 (2020-04-01)
Staphylococcus aureus is one of the major bacterial mastitis pathogens with significant effects on animal and human health. Some studies showed that S. aureus strains that infect different host species are genetically distinct, although most strains can infect a wide
Howard J Green et al.
International journal of general medicine, 2, 227-242 (2009-01-01)
The objective of this paper is to provide an overview of the recent developments in muscle physiology and biochemistry in general, and with respect to chronic obstructive pulmonary disease (COPD) specifically. As a way of illustration, we have presented data
Raluca Pais et al.
European journal of internal medicine, 26(1), 30-36 (2015-01-03)
The association of NAFLD with chronic hepatitis C (CHC) has been extensively studied but little is known about its coexistence with chronic hepatitis B (CHB). To investigate the prevalence and determinants of steatosis and insulin resistance (IR) in CHB and
James W F Catto et al.
International journal of cancer, 105(4), 484-490 (2003-04-25)
Defects in the DNA mismatch repair proteins result in microsatellite instability and malignancy in hereditary non-polyposis colorectal carcinoma (HNPCC). However, the role of mismatch repair (MMR) proteins and microsatellite instability (MSI) in transitional cell carcinoma of the bladder is less
Antonis Elia et al.
European journal of applied physiology, 121(3), 827-838 (2020-12-30)
This study examined the influence of dynamic apnoea training on splenic volume and haematological responses in non-breath-hold divers (BHD). Eight non-BHD performed ten maximal dynamic apnoeas, four times a week for six weeks. Splenic volumes were assessed ultrasonically, and blood
Ivan Cakulev et al.
Journal of cardiovascular electrophysiology, 22(11), 1266-1273 (2011-05-28)
Vanoxerine is a promising, new, investigational antiarrhythmic drug. The purpose of this study was to test the hypothesis that oral dosing of vanoxerine would first terminate induced atrial flutter (AFL) and atrial fibrillation (AF), and then prevent their reinduction. In
Daniela C Fuhr et al.
The lancet. Psychiatry, 6(2), 115-127 (2019-01-29)
The Thinking Healthy Programme (THP) is a psychological intervention recommended for the treatment of perinatal depression. However, efforts to integrate the intervention at scale into the routines of community health workers who delivered the THP when it was first evaluated
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