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Paola Mura et al.
International journal of pharmaceutics, 547(1-2), 530-536 (2018-06-17)
The work was aimed at developing an in vitro method able to provide rapid and reliable evaluation of drug absorption through buccal mucosa. Absorption simulator apparatus endowed with an artificial membrane was purposely developed by experimental design. The apparent permeation
N Kawamura et al.
The Biochemical journal, 283 ( Pt 3), 705-712 (1992-05-01)
The third component of complement (C3) is an important mediator of inflammation. Murine and human genomic cosmid clones were isolated, characterized and sequenced 5' to the complement C3 gene transcriptional initiation sites to determine cis elements that participate in constitutive
Xia Kong et al.
Molecular medicine reports, 12(1), 895-904 (2015-03-12)
Previous studies investigating the role of toll-like receptors (TLRs) in asthma have been inconclusive. It has remained elusive whether the toll-like receptors (TLR2)/mycloid differentiation factor 88 (MyD88)/nuclear factor (NF)-κB signaling pathway is involved in lipoxin A4 (LXA4)-induced protection against asthma.
Gerhard Binder et al.
Clinical endocrinology, 82(1), 100-105 (2014-09-11)
The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in
Wilfredo F Garcia-Beltran et al.
Cell, 185(3), 457-466 (2022-01-08)
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we measured the neutralization potency of sera
M L Katz et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 10(11), 1050-1053 (1999-11-11)
Late-infantile ceroid-lipofuscinosis (CLN2) is an autosomal recessively inherited, neurodegenerative disease in humans. The CLN2 locus has been mapped to Chromosome (Chr) 11p15, and its sequence and genomic organization have recently been reported. In the present study, the cDNA sequence, exon/intron
R E Reiter et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(4), 1735-1740 (1998-03-21)
The identification of cell surface antigens is critical to the development of new diagnostic and therapeutic modalities for the management of prostate cancer. Prostate stem cell antigen (PSCA) is a prostate-specific gene with 30% homology to stem cell antigen 2
David Akhavan et al.
Cancer biotherapy & radiopharmaceuticals, 35(1), 10-15 (2020-01-08)
Background: M5A is a humanized monoclonal antibody (mAb) directed against carcinoembryonic antigen (CEA) The purpose of this first in
M Asefi et al.
The British journal of dermatology, 167(6), 1279-1286 (2012-07-28)
Paraoxonase 1 (PON1) is a serum high-density lipoprotein-bound enzyme with antioxidant function. It hydrolyses lipid peroxides, protecting low-density lipoproteins from oxidative modifications. Patients with psoriasis are at greater risk of oxidative stress, which is associated with abnormal plasma lipid metabolism.
K Guzman et al.
DNA and cell biology, 10(8), 593-601 (1991-10-01)
Follicle-stimulating hormone (FSH), the primary stimulus for egg and sperm maturation in mammals, is an alpha/beta heterodimer. Each subunit is encoded by a single-copy gene in the human, bovine, and rat genomes. Transcription of both subunits is inhibited by estradiol
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