112-16-3

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Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India.

Abraham Koshy et al.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 25(3), 140-142 (2006-08-01)

Factor V Leiden has been reported in 2%-30% of patients with portal vein thrombosis. This wide variation makes it difficult to assess the importance of factor V Leiden as a predisposing factor. Factor V Leiden was determined by restriction fragment

Identification and typing of Brucella spp. in stranded harbour porpoises (Phocoena phocoena) on the Dutch coast.

Elisa Maio et al.

Veterinary microbiology, 173(1-2), 118-124 (2014-08-15)

The presence of Brucella (B.) spp. in harbour porpoises stranded between 2008 and 2011 along the Dutch coast was studied. A selection of 265 tissue samples from 112 animals was analysed using conventional and molecular methods. In total, 4.5% (5/112)

Effects of fatty acids and calf starter form on intake, growth, digestion, and selected blood metabolites in male calves from 0 to 4 months of age.

J D Quigley et al.

Journal of dairy science, 102(9), 8074-8091 (2019-07-22)

The objective of this research was to determine if form of calf starter (CS) and addition of a fatty acid blend (FA) influenced intake, growth, digestion, and indices of immune status and stress in calves from 0 to 4 mo

Homogeneous EGFR amplification defines a subset of aggressive Barrett's adenocarcinomas with poor prognosis.

Andreas H Marx et al.

Histopathology, 57(3), 418-426 (2010-09-16)

The epidermal growth factor receptor (EGFR) is a tyrosine kinase (TK) involved in the tumour progression of many cancer types and may serve as an important therapeutic target (erlotinib, cetuximab). Heterogeneity of EGFR amplification and expression could represent a major

PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses.

Eisaburo Ichikawa et al.

Journal of human genetics, 51(1), 38-46 (2005-10-26)

The prevalence of nonsyndromic cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO) are believed to be higher in the Japanese than in Americans, Europeans or Africans. The purpose of this study was to investigate, in

Diagnostic value of immunohistochemical IMP3 expression in core needle biopsies of pancreatic ductal adenocarcinoma.

David Lukas Wachter et al.

The American journal of surgical pathology, 35(6), 873-877 (2011-05-14)

The oncofetal protein, insulin-like growth factor II messenger ribonucleic acid-binding protein 3 (IMP3), has been analyzed in many different tumors. Various studies have found that IMP3 is a marker for malignancy and is correlated with increased tumor aggressiveness and reduced

Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats.

Drew A Graham et al.

Journal of applied physiology (Bethesda, Md. : 1985), 107(4), 1059-1067 (2009-08-22)

Cyclooxygenase (COX)-derived vasoconstrictory prostanoids contribute to impaired endothelium-dependent vasorelaxation in aging male (m) spontaneously hypertensive rats (SHR); however, vasomotor responses in aging female (f) SHR and sex differences in aging SHR are unknown. Examining mechanisms governing dysfunction in aging fSHR

Video corroboration of player incurred impacts using trunk worn sensors among national ice-hockey team members.

Aaron Pilotti-Riley et al.

PloS one, 14(6), e0218235-e0218235 (2019-06-25)

Video corroboration of player incurred impacts (PII) using trunk-worn wearable sensors (WS) among national ice-hockey team members. 23 members of the U.S. National (NTDP) U18 team consented to procedures approved by EMU Human Subjects Committee. Bioharness-3 (Zephyr, MD) WS recorded

Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta integrin antagonist, in patients with solid tumours.

M E Cianfrocca et al.

British journal of cancer, 94(11), 1621-1626 (2006-05-18)

To evaluate the toxicity, pharmacological and biological properties of ATN-161, a five -amino-acid peptide derived from the synergy region of fibronectin, adult patients with advanced solid tumours were enrolled in eight sequential dose cohorts (0.1-16 mg kg(-1)), receiving ATN-161 administered

Sustained reduction in methane production from long-term addition of 3-nitrooxypropanol to a beef cattle diet.

A Romero-Perez et al.

Journal of animal science, 93(4), 1780-1791 (2015-05-29)

The objective was to evaluate whether long-term addition of 3-nitrooxypropanol (NOP) to a beef cattle diet results in a sustained reduction in enteric CH4 emissions in beef cattle. Eight ruminally cannulated heifers (637 ± 16.2 kg BW) were used in

Relation between angiotensin-converting enzyme II genotype and atrial fibrillation in Japanese patients with hypertrophic cardiomyopathy.

Akiyoshi Ogimoto et al.

Journal of human genetics, 47(4), 184-189 (2002-08-09)

Atrial fibrillation (AF) occurs in about 20% of patients with hypertrophic cardiomyopathy (HCM). HCM patients with AF have an increased risk for clinical decline and thromboembolism. In addition, AF is known to be associated with the atrial renin-angiotensin system (RAS).

MAP0004, orally inhaled dihydroergotamine for acute treatment of migraine: efficacy of early and late treatments.

Stewart J Tepper et al.

Mayo Clinic proceedings, 86(10), 948-955 (2011-10-04)

To evaluate the efficacy of MAP0004, an orally inhaled dihydroergotamine, for acute treatment of migraine when administered at various time points from within 1 hour to more than 8 hours after migraine onset. This post hoc subanalysis was conducted using

MALDI-TOF mass spectrometry screening of cholelithiasis risk markers in the gene of HNF1alpha.

Dominique Richter et al.

Journal of proteomics, 75(12), 3386-3399 (2012-05-10)

In recent years MALDI-TOF MS gained importance for high-throughput DNA analysis. In the present study this technique was used for the pathogenetic analysis of gallstone disease. The intestinal apical sodium-dependent bile acid transporter (ASBT) shows a genetic association with gallstone

Endothelin-1 attenuates apoptosis in cultured trophoblasts from term human placentas.

M Cervar-Zivkovic et al.

Reproductive sciences (Thousand Oaks, Calif.), 14(5), 430-439 (2007-10-05)

The authors test the hypothesis that endothelin-1 (ET-1) modulates apoptosis in human term trophoblasts. Primary cultures of cytotrophoblasts from term human placentas (n = 5) were cultured for 16 hours total or 24 hours prior to harvest at 72 hours

Unexplained extreme hyperbilirubinemia among neonates in a multihospital healthcare system.

Robert D Christensen et al.

Blood cells, molecules & diseases, 50(2), 105-109 (2012-11-06)

We report a series of neonates who developed a total serum bilirubin (TSB) >20mg/dL during a recent ten-year period in a multihospital healthcare system. The incidence of a TSB >20mg/dL fell after instituting a pre-hospital discharge bilirubin screening program in

Effectiveness and adverse effects of the use of apomorphine and 3% hydrogen peroxide solution to induce emesis in dogs.

Safdar A Khan et al.

Journal of the American Veterinary Medical Association, 241(9), 1179-1184 (2012-10-20)

To determine the effectiveness and adverse effects of apomorphine and 3% hydrogen peroxide solution used for emesis in dogs. Prospective observational study. 147 dogs that received apomorphine (IV or placed in the conjunctival sac) or 3% hydrogen peroxide solution (PO)

A functionally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated beta1 integrin.

Maria Dolores Gutierrez-Lopez et al.

The Journal of biological chemistry, 278(1), 208-218 (2002-11-02)

Tetraspanins associate on the cell membrane with several transmembrane proteins, including members of the integrin superfamily. The tetraspanin CD9 has been implicated in cell motility, metastasis, and sperm-egg fusion. In this study we characterize the first CD9 conformation-dependent epitope (detected

Effects of activation with a Ca ionophore and roscovitine on the development of human oocytes that failed to fertilize after ICSI.

Ayako Suto et al.

The journal of medical investigation : JMI, 70(3.4), 321-324 (2023-11-09)

The effects of oocyte activation with a Ca ionophore and roscovitine (Ca+R), a selective inhibitor of M-phase promoting factor, on unfertilized oocytes after intracytoplasmic sperm injection (ICSI) or testicular sperm extraction (TESE)-ICSI were evaluated. Oocytes without pronuclei at 18 hours

Implications of NRAS mutations in AML: a study of 2502 patients.

Ulrike Bacher et al.

Blood, 107(10), 3847-3853 (2006-01-26)

We analyzed 2502 patients with acute myeloid leukemia at diagnosis for NRAS mutations around the hot spots at codons 12, 13, and 61 and correlated the results to cytomorphology, cytogenetics, other molecular markers, and prognostic relevance of these mutations. Two

Dihydropyrimidine dehydrogenase circadian rhythm in mouse liver: comparison between enzyme activity and gene expression.

B Porsin et al.

European journal of cancer (Oxford, England : 1990), 39(6), 822-828 (2003-03-26)

Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (FU) catabolism. The relevance of the measurement of DPD activity for identifying DPD-deficient patients is lessened by circadian variability in DPD activity. Our purpose was to determine whether or not DPD

Moderate caloric restriction during gestation results in lower arcuate nucleus NPY- and alphaMSH-neurons and impairs hypothalamic response to fed/fasting conditions in weaned rats.

A P García et al.

Diabetes, obesity & metabolism, 12(5), 403-413 (2010-04-27)

We aimed to characterize the developmental programming effects of moderate caloric restriction during early pregnancy on factors involved in hypothalamic control of energy balance. Twenty-five-days-old offspring Wistar rats from 20% caloric restricted dams (from 1 to 12 days of pregnancy)

The comparative metabolic response of Bactrocera dorsalis larvae to azadirachtin, pyriproxyfen and tebufenozide.

You Zhou et al.

Ecotoxicology and environmental safety, 189, 110020-110020 (2019-12-07)

Azadirachtin, as the most promising and effective botanical insecticide, exhibits significant growth inhibition activity against agricultural and forestry pests. However, its biochemical effects at the metabolic level compared with those of other insect growth regulators have not been studied. Therefore

Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice.

Daniel Teupser et al.

Proceedings of the National Academy of Sciences of the United States of America, 103(1), 123-128 (2005-12-29)

Atherosclerosis is a complex disease that is affected by environmental as well as genetic factors. The aim of the present study was to identify loci of atherosclerosis susceptibility in a cross of atherosclerosis-susceptible C57BL/6 and atherosclerosis-resistant FVB/N mice on the

Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rats: a comparative study.

Iraj Yazdani et al.

BMC pharmacology & toxicology, 23(1), 59-59 (2022-08-06)

Testicular torsion is a pathological condition which needs emergency surgical intervention. However, after surgical reperfusion, oxidative stress factors cause to germ cell apoptosis. The study was planned to evaluate the efficacy of simultaneous use of Cyclosporine A (CsA) and Nortriptyline (Nort)

Effect of Low-Intensity Pulsed Ultrasound After Autologous Adipose-Derived Stromal Cell Transplantation for Bone-Tendon Healing in a Rabbit Model.

Can Chen et al.

The American journal of sports medicine, 47(4), 942-953 (2019-03-15)

Low-intensity pulsed ultrasound (LIPUS), as a safe biophysiotherapy, can enhance bone-tendon (B-T) healing in vivo and induce osteogenic or chondrogenic differentiation of mesenchymal stromal cells in vitro. This study aimed to determine whether LIPUS can improve the efficacy of transplanted

Expression of a novel oncofetal mRNA-binding protein IMP3 in endometrial carcinomas: diagnostic significance and clinicopathologic correlations.

Cuizhen Li et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 20(12), 1263-1268 (2007-09-22)

Insulin-like growth factor-II mRNA-binding protein 3 (IMP3) is a newly identified oncofetal mRNA-binding protein that is involved in embryogenesis and carcinogenesis of some malignant neoplasms. To investigate the diagnostic and clinicopathologic significance of this protein in endometrial carcinomas, we evaluated

Amino acid limitation and flow to the duodenum at four stages of lactation. 2. Extent of lysine limitation.

C G Schwab et al.

Journal of dairy science, 75(12), 3503-3518 (1992-12-01)

Four multiparous Holstein cows with ruminal and duodenal cannulas were assigned to 4 x 4 Latin squares at peak (wk 4), early (wk 14 to 16), mid (wk 21 to 23), and late (wk 29 to 31) lactation to determine

Danger-recognizing proteins, β-defensin-128 and histatin-3, as potential biomarkers of recurrent coronary events.

Madankumar Ghatge et al.

International journal of molecular medicine, 40(2), 531-538 (2017-06-20)

Conventional risk factors have limited ability to predict recurrent events in subjects with first-time coronary artery disease (CAD). This aim of this study was to identify novel biomarkers using comparative global proteome analysis to improve the risk assessment for recurrent coronary

Linkage mapping in 29 Bardet-Biedl syndrome families confirms loci in chromosomal regions 11q13, 15q22.3-q23, and 16q21.

E A Bruford et al.

Genomics, 41(1), 93-99 (1997-04-01)

Bardet-Biedl syndrome (BBS) is a clinically and genetically heterogeneous autosomal recessive disorder characterized by retinitis pigmentosa, polydactyly, obesity, hypogenitalism, mental retardation, and renal anomalies. To detect linkage to BBS loci, 29 BBS families, of mixed but predominantly European ethnic origin

Normal insulin-like peptide-3 levels despite low testosterone in adult males with Prader-Willi syndrome: variations in Leydig cell function from infancy through adulthood.

Harry J Hirsch et al.

The Journal of clinical endocrinology and metabolism, 98(1), E135-E143 (2012-11-15)

Cryptorchidism, incomplete pubertal development, and low testosterone are manifestations of hypogonadism in Prader-Willi syndrome (PWS). Insulin-like peptide-3 (INSL3) facilitates testicular descent in the fetus and reflects Leydig cell number in adults. INSL3 levels in PWS have not been previously reported.

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