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关键词:'112-48-1'
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Rille Pullerits et al.
Arthritis research & therapy, 10(3), R72-R72 (2008-06-28)
TNFalpha and high mobility group box chromosomal protein 1 (HMGB1) are two potent proinflammatory cytokines implicated as important mediators of arthritis. Increased levels of these cytokines are found in the joints of rheumatoid arthritis patients, and the cytokines trigger arthritis
Willard Tinago et al.
PloS one, 9(5), e97011-e97011 (2014-05-13)
Although effective antiretroviral therapy(ART) increases CD4+ T-cell count, responses to ART vary considerably and only a minority of patients normalise their CD4+/CD8+ ratio. Although retention of naïve CD4+ T-cells is thought to predict better immune responses, relationships between CD4+ and
Lacy A Holowatz et al.
The Journal of physiology, 581(Pt 2), 863-872 (2007-03-10)
Reflex cutaneous vasodilatation is dependent on nitric oxide (NO), which is diminished in hypertension (HTN). Arginase may be up-regulated with HTN, which preferentially metabolizes L-arginine (L-arg), competing with NO-synthase (NOS)-mediated pathways and limiting NO synthesis. We hypothesized that NO-dependent vasodilatation
Daniel E Jonas et al.
JAMA, 311(18), 1889-1900 (2014-05-16)
Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused. To conduct a systematic review and meta-analysis of the benefits and harms of medications (US FDA-approved and others) for adults with alcohol use
Michael Eckstein et al.
The Israel Medical Association journal : IMAJ, 4(5), 340-344 (2002-06-04)
Genetic factors have been shown to play a major role in the development of peak bone mass, with hereditability accounting for about 50-85% of the variance in bone mass. Numerous candidate genes involved in osteoporosis have been proposed, but the
Paula Esquivias et al.
World journal of gastroenterology, 18(35), 4866-4874 (2012-09-25)
To evaluate the effects of indomethacin [dual cyclooxygenase (COX)-1/COX-2 inhibitor] and 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl) phenyl)-2-(5H)-furanone (MF-tricyclic) (COX-2 selective inhibitor) in a rat experimental model of Barrett's esophagus and esophageal adenocarcinoma. A total of 112 surviving post-surgery rats were randomly divided into three
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