113018

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Expression of the entire polyhydroxybutyrate operon of

Rita Mozes-Koch et al.

Journal of biological engineering, 11, 44-44 (2017-12-05)

Previously we demonstrated that an entire bacterial operon (the PRN operon) is expressible in plants when driven by the Tomato -yellow-leaf-curl-virus (TYLCV) -derived universal vector IL-60.Petroleum-derived plastics are not degradable, and are therefore harmful to the environment. Fermentation of bacteria

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.

Alexander Duscha et al.

Cell, 180(6), 1067-1080 (2020-03-12)

Short-chain fatty acids are processed from indigestible dietary fibers by gut bacteria and have immunomodulatory properties. Here, we investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease. Serum and feces of subjects with MS exhibited significantly

Photosynthetic poly-β-hydroxybutyrate accumulation in unicellular cyanobacterium Synechocystis sp. PCC 6714.

Donya Kamravamanesh et al.

AMB Express, 7(1), 143-143 (2017-07-09)

Poly-β-hydroxybutyrate (PHB) production from CO

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

Brian D Hudson et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(12), 4951-4965 (2012-08-25)

When it is difficult to develop selective ligands within a family of related G-protein-coupled receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (RASSLs) are useful alternatives for probing receptor function. In the present work, we explored whether a

Correlation between 12α-hydroxylated bile acids and insulin secretion during glucose tolerance tests in rats fed a high-fat and high-sucrose diet.

Reika Yoshitsugu et al.

Lipids in health and disease, 19(1), 9-9 (2020-01-17)

Previously, we found a significant relationship in a rat study between energy intake and bile acid (BA) metabolism especially 12α-hydroxylated (12αOH) BAs. The present study was designed to reveal relationships among BA metabolism, glucose tolerance, and cecal organic acids in

Towards sustainable bioplastic production using the photoautotrophic bacterium Rhodopseudomonas palustris TIE-1.

Tahina Onina Ranaivoarisoa et al.

Journal of industrial microbiology & biotechnology, 46(9-10), 1401-1417 (2019-03-31)

Bacterial synthesis of polyhydroxybutyrates (PHBs) is a potential approach for producing biodegradable plastics. This study assessed the ability of Rhodopseudomonas palustris TIE-1 to produce PHBs under various conditions. We focused on photoautotrophy using a poised electrode (photoelectroautotrophy) or ferrous iron

Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase.

Dhara D Shah et al.

Journal of the American Chemical Society, 139(40), 14322-14330 (2017-09-14)

The dehydratase domain FosDH1 from module 1 of the fostriecin polyketide synthase (PKS) catalyzed the stereospecific interconversion of (3R)-3-hydroxybutyryl-FosACP1 (5) and (E)-2-butenoyl-FosACP1 (11), as established by a combination of direct LC-MS/MS and chiral GC-MS. FosDH1 did not act on either

Metabolic flux analysis and the NAD(P)H/NAD(P)

Andres García et al.

Microbial cell factories, 17(1), 10-10 (2018-01-24)

Azotobacter vinelandii is a bacterium that produces alginate and polyhydroxybutyrate (P3HB); however, the role of NAD(P)H/NAD(P) The results reveal that changes in the oxygen availability have an important effect on the metabolic fluxes and intracellular NADPH/NADP We have demonstrated that

Growth performance, rumen fermentation, bacteria composition, and gene expressions involved in intracellular pH regulation of rumen epithelium in finishing Hu lambs differing in residual feed intake phenotype.

Y S Liang et al.

Journal of animal science, 95(4), 1727-1738 (2017-05-04)

The objective of this study was to evaluate the effect of residual feed intake (RFI) on rumen function in finishing lambs. A total of 60 male Hu lambs (average initial BW = 25.2 ± 2.5kg) were used and were offered

Swelling Studies of Copolymeric Acrylamide/Crotonic Acid Hydrogels as Carriers for Agricultural Uses.

Karadag E, et al.

Polymers For Advanced Technologies, 11(2), 59-68 (2000)

Metabolic engineering of Yarrowia lipolytica for the biosynthesis of crotonic acid.

Lei Wang et al.

Bioresource technology, 287, 121484-121484 (2019-05-24)

In this study, Y. lipolytica was engineered to produce crotonic acid via the butanol-forming route. Firstly, the crotonase and 3-hydroxybutyryl-CoA dehydrogenase genes from Clostridium beijerinckii, and the thioesterase gene from Bacteroides thetaiotaomicron were heterologously expressed in Y. lipolytica, the engineered

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

J P D van Veldhoven et al.

Bioorganic & medicinal chemistry letters, 21(9), 2736-2739 (2010-12-21)

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids and esters such as methyl fumarate also interact with the

Two-stage (photoautotrophy and heterotrophy) cultivation enables efficient production of bioplastic poly-3-hydroxybutyrate in auto-sedimenting cyanobacterium.

Tanakarn Monshupanee et al.

Scientific reports, 6, 37121-37121 (2016-11-16)

Sustainable production of bioplastics by heterotrophic microbes has been restricted by the limited resources of organic substrates and the energy required for biomass harvest. Here, the easy-to-harvest cyanobacterium (Chlorogloea fritschii TISTR 8527), from which the biomass instantaneously settled to the

Molecular mass of Poly-3-hydroxybutyrate (P3HB) produced by Azotobacter vinelandii is influenced by the polymer content in the inoculum.

Modesto Millán et al.

Journal of biotechnology, 259, 50-55 (2017-08-24)

Poly-3-hydroxybutyrate (P3HB) is a biopolymer produced by Azotobacter vinelandii. The physicochemical properties and applications of P3HB are strongly influenced by its weight-average molecular mass (Mw), and in A. vinelandii, it could be influenced by the culture conditions. The aim of

Computational redesign of enzymes for regio- and enantioselective hydroamination.

Ruifeng Li et al.

Nature chemical biology, 14(7), 664-670 (2018-05-23)

Introduction of innovative biocatalytic processes offers great promise for applications in green chemistry. However, owing to limited catalytic performance, the enzymes harvested from nature's biodiversity often need to be improved for their desired functions by time-consuming iterative rounds of laboratory

Paracoccus indicus sp. nov., isolated from surface seawater in the Indian Ocean.

Danqiu Lin et al.

Antonie van Leeuwenhoek, 112(6), 927-933 (2019-02-10)

Strain IO390502T, isolated from surface seawater in the Indian Ocean, was characterised using a polyphasic taxonomy approach. Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain IO390502T belongs to the genus Paracoccus and is closely related to Paracoccus

Single-dose infusion of sodium butyrate, but not lactose, increases plasma β-hydroxybutyrate and insulin in lactating dairy cows.

K J Herrick et al.

Journal of dairy science, 100(1), 757-768 (2016-11-14)

Several studies have identified beneficial effects of butyrate on rumen development and intestinal health in preruminants. These encouraging findings led to further investigations related to butyrate supplementation in the mature ruminant. However, the effects of elevated butyrate concentrations on rumen

Anti-obesity effects of α-amylase inhibitor enriched-extract from white common beans (Phaseolus vulgaris L.) associated with the modulation of gut microbiota composition in high-fat diet-induced obese rats.

Zhenxing Shi et al.

Food & function, 11(2), 1624-1634 (2020-02-06)

α-Amylase inhibitors (α-AI) have great potential to treat obesity. In this study, an α-AI enriched extract (α-AIE) with a specific activity of 1027.1 ± 154.2 (U per mg protein) was prepared from white common bean (Phaseolus vulgaris L.) seeds. Its

Chemical renal medullectomy. Effect on urinary prostaglandin E2 and plasma renin in response to variations in sodium intake and in relation to blood pressure.

R F Bing et al.

Hypertension (Dallas, Tex. : 1979), 5(6), 951-957 (1983-11-01)

We have studied the possible vasodepressor role of the renal medulla by chemical medullectomy. Bromoethylamine hydrobromide (200 mg/kg) was injected to induce selective renal medullary necrosis in rats. The acute effects on sodium balance and long-term effects on blood pressure

Overexpression of luxS Promotes Stress Resistance and Biofilm Formation of Lactobacillus paraplantarum L-ZS9 by Regulating the Expression of Multiple Genes.

Lei Liu et al.

Frontiers in microbiology, 9, 2628-2628 (2018-11-30)

Probiotics have evoked great interest in the past years for their beneficial effects. The aim of this study was to investigate whether luxS overexpression promotes the stress resistance of Lactobacillus paraplantarum L-ZS9. Here we show that overexpression of luxS gene

Microwave-assisted synthesis of porphyrin conjugated microporous polymers for microextraction of volatile organic acids in tobaccos.

Yi Peng et al.

Journal of chromatography. A, 1594, 45-53 (2019-02-26)

Conjugated microporous polymers (CMPs) with permanent microporosity and extended p-conjugated skeletons have recently shown the fascinating application in separation and enrichment. In this report, porphyrin CMP that possessed microporous structure and nitrogen-rich pyrrole building blocks was successfully synthesized by microwave-assisted

Identification of the toxic trigger in mushroom poisoning.

Masanori Matsuura et al.

Nature chemical biology, 5(7), 465-467 (2009-05-26)

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum

Characterization of heterotrophic growth and sesquiterpene production by Rhodobacter sphaeroides on a defined medium.

Enrico Orsi et al.

Journal of industrial microbiology & biotechnology, 46(8), 1179-1190 (2019-06-13)

Rhodobacter sphaeroides is a metabolically versatile bacterium capable of producing terpenes natively. Surprisingly, terpene biosynthesis in this species has always been investigated in complex media, with unknown compounds possibly acting as carbon and nitrogen sources. Here, a defined medium was

The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen.

Qi Wang et al.

Cell reports, 31(3), 107528-107528 (2020-04-23)

Identification of multiple histone acylations diversifies transcriptional control by metabolism, but their functions are incompletely defined. Here we report evidence of histone crotonylation in the human fungal pathogen Candida albicans. We define the enzymes that regulate crotonylation and show its

The bacterial and archaeal community structures and methanogenic potential of the cecal microbiota of goats fed with hay and high-grain diets.

Wei Jin et al.

Antonie van Leeuwenhoek, 111(11), 2037-2049 (2018-05-19)

The cecum plays an important role in the feed fermentation of ruminants. However, information is very limited regarding the cecal microbiota and their methane production. In the present study, the cecal content from twelve local Chinese goats, fed with either

Correlations between Structure and Near-Infrared Spectra of Saturated and Unsaturated Carboxylic Acids. Insight from Anharmonic Density Functional Theory Calculations.

Justyna Grabska et al.

The journal of physical chemistry. A, 121(18), 3437-3451 (2017-04-18)

By near-infrared (NIR) spectroscopy and anharmonic density functional theory (DFT) calculations, we investigate five kinds of saturated and unsaturated carboxylic acids belonging to the group of short-chain fatty acids: propionic acid, butyric acid, acrylic acid, crotonic acid, and vinylacetic acid.

Enhancement of FK520 production in Streptomyces hygroscopicus by combining traditional mutagenesis with metabolic engineering.

Zhituo Yu et al.

Applied microbiology and biotechnology, 103(23-24), 9593-9606 (2019-11-13)

FK520 (ascomycin), a 23-membered macrolide with immunosuppressive activity, is produced by Streptomyces hygroscopicus. The problem of low yield and high impurities (mainly FK523) limits the industrialized production of FK520. In this study, the FK520 yield was significantly improved by strain

Functional Oocytes Derived from Granulosa Cells.

Chenglei Tian et al.

Cell reports, 29(13), 4256-4267 (2019-12-26)

The generation of genomically stable and functional oocytes has great potential for preserving fertility and restoring ovarian function. It remains elusive whether functional oocytes can be generated from adult female somatic cells through reprogramming to germline-competent pluripotent stem cells (gPSCs)

Fatty acid profile, physicochemical composition and sensorial attributes of salted and sun-dried meat from young Nellore bulls supplemented with condensed tannins.

Susana Melo Gesteira et al.

PloS one, 14(4), e0216047-e0216047 (2019-04-27)

The objective of this study was to evaluate the effect of condensed tannin inclusion (0, 10, 30 or 50 g/kg of dry matter (DM) total) from Acacia mearnsii extract on the fatty acid profile, physicochemical quality and sensorial analysis of

Polyhydroxybutyrate production by an extremely halotolerant Halomonas elongata strain isolated from the hypersaline meromictic Fără Fund Lake (Transylvanian Basin, Romania).

A Cristea et al.

Journal of applied microbiology, 125(5), 1343-1357 (2018-06-22)

This study aimed at unprecedented physical and chemical evaluation of the 'green plastics' polyhydroxyalkanoates (PHAs), in an extremely halotolerant Halomonas elongata strain 2FF under high-salt concentration. The investigated bacterial strain was isolated from the surface water of the hypersaline Fără

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