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Rodrigo W A Souza et al.
PloS one, 9(10), e110020-e110020 (2014-10-21)
Heart failure (HF) is associated with cachexia and consequent exercise intolerance. Given the beneficial effects of aerobic exercise training (ET) in HF, the aim of this study was to determine if the ET performed during the transition from cardiac dysfunction
Leona Daniela Jeffery Daim et al.
Electrophoresis, 36(15), 1699-1710 (2015-05-02)
The basidiomycete fungal pathogen Ganoderma boninense is the causative agent for the incurable basal stem rot (BSR) disease in oil palm. This disease causes significant annual crop losses in the oil palm industry. Currently, there is no effective method for
Rachel L Gillespie et al.
Investigative ophthalmology & visual science, 56(2), 883-891 (2015-01-13)
To define the phenotypic manifestation, confirm the genetic basis, and delineate the pathogenic mechanisms underlying an oculoauricular syndrome (OAS). Two individuals from a consanguineous family underwent comprehensive clinical phenotyping and electrodiagnostic testing (EDT). Genome-wide microarray analysis and Sanger sequencing of
Birgit Steinmetz et al.
Cell cycle (Georgetown, Tex.), 13(18), 2931-2943 (2014-12-09)
The product of the ecotropic virus integration site 1 (EVI1) gene, whose overexpression is associated with a poor prognosis in myeloid leukemias and some epithelial tumors, regulates gene transcription both through direct DNA binding and through modulation of the activity
Marina Rolo Pinheiro da Rosa et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 11107-11120 (2014-08-08)
Ameloblastoma is an odontogenic tumor characterized by local invasiveness and frequent recurrence. The surrounding stroma, composed of different cell types and extracellular matrix (ECM), may influence ameloblastoma invasive behavior. Furthermore, tumor and stromal cells secrete matrix metalloproteases (MMPs), which, in
Lindsay M Reynolds et al.
BMC genomics, 16, 333-333 (2015-04-23)
Transcriptomic studies hold great potential towards understanding the human aging process. Previous transcriptomic studies have identified many genes with age-associated expression levels; however, small samples sizes and mixed cell types often make these results difficult to interpret. Using transcriptomic profiles
Benshui Shu et al.
Archives of insect biochemistry and physiology, 89(3), 153-168 (2015-04-02)
The induction of apoptosis by azadirachtin, a well-known botanical tetranortriterpenoid isolated from the neem tree (Azadirachta indica A. Juss) and other members of the Meliaceae, was investigated in Spodoptera frugiperda cultured cell line (Sf9). Morphological changes in Sf9 cells treated
Pablo Emiliano Canton et al.
BMC genomics, 16, 1042-1042 (2015-12-10)
Although much is known about the mechanism of action of Bacillus thuringiensis Cry toxins, the target tissue cellular responses to toxin activity is less understood. Previous transcriptomic studies indicated that significant changes in gene expression occurred during intoxication. However, most
Iman Chouikha et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), 18709-18714 (2014-12-03)
The arthropod-borne transmission route of Yersinia pestis, the bacterial agent of plague, is a recent evolutionary adaptation. Yersinia pseudotuberculosis, the closely related food-and water-borne enteric species from which Y. pestis diverged less than 6,400 y ago, exhibits significant oral toxicity
Vinko Besic et al.
PloS one, 10(3), e0119270-e0119270 (2015-03-06)
Type 2 diabetes mellitus (T2DM) results from a combination of progressive insulin resistance and loss of pancreatic beta cell function and/or mass. Insulin signalling occurs through the insulin receptor, (INSR) which is alternatively spliced into two isoforms: INSRA (-exon 11)
John E Buonora et al.
Journal of neurotrauma, 32(22), 1805-1814 (2015-05-06)
Autoimmune profiling in rats revealed the antioxidant enzyme, peroxiredoxin 6 (PRDX6), as a target for autoantibodies evoked in response to traumatic brain injury (TBI). Consistent with this proposal, immunohistochemical analysis of rat cerebral cortex demonstrated that PRDX6 is highly expressed
Ying Lin et al.
Biomacromolecules, 9(10), 2629-2636 (2008-08-14)
Amphiphilic biodegradable star-shaped polymer was conveniently prepared by the Sn(Oct)2-catalyzed ring opening polymerization of epsilon-caprolactone (CL) with hyperbranched poly(ester amide) (PEA) as a macroinitiator. Various monomer/initiator ratios were employed to vary the length of the PCL arms. (1)H NMR and
Mariana Carneiro et al.
Ecotoxicology and environmental safety, 120, 93-101 (2015-06-06)
Anatoxin-a is a potent neurotoxin produced by several genera of cyanobacteria. Deaths of wild and domestic animals due to anatoxin-a exposure have been reported following a toxic response that is driven by the inhibition of the acetylcholine receptors at neuromuscular
Siao-Syun Guan et al.
Oncotarget, 5(13), 4868-4880 (2014-06-21)
Colorectal cancer (CRC) is known as a common malignant neoplasm worldwide. The role of EGFR/HER2 in CRC is unclear. Afatinib is an irreversible EGFR/HER2 inhibitor. There were few studies of afatinib on CRC. Here, we investigated the protein levels/expressions of
L Félix-Valenzuela et al.
Letters in applied microbiology, 61(4), 367-373 (2015-07-16)
The fruit juice industry recognizes Alicyclobacillus as a major quality control target micro-organism. In this study, we analysed 19 bacterial isolates to identify Alicyclobacillus species by polymerase chain reaction (PCR) and sequencing analyses. Phenotypic and genomic diversity among isolates were
Wei Xiong et al.
Clinical and experimental pharmacology & physiology, 42(7), 780-787 (2015-05-08)
Neuropathic pain is a common and severely disabling state that affects millions of people worldwide. The P2X3 receptor plays a crucial role in facilitating pain transmission. Intermedin (IMD), which is also known as adrenomedullin 2 (AMD2) is a newly discovered
M Cheema et al.
Journal of dairy science, 98(8), 5155-5163 (2015-06-16)
The agreed biological function of the casein micelles in milk is to carry minerals (calcium, magnesium, and phosphorus) from mother to young along with amino acids for growth and development. Recently, native and modified casein micelles were used as encapsulating
Aline K A L Cipriano et al.
Journal of proteomics, 113, 90-109 (2014-10-08)
Gummosis is an aggressive disease caused by the necrotrophic fungus Lasiodiplodia theobromae (Pat.) Griffon & Maubl that threatens commercial cashew orchads in Brazil. To study the molecular mechanisms involved in the cashew response to L. theobromae, a proteomic analysis of
Akul Y Mehta et al.
Cell chemical biology, 27(9), 1207-1219 (2020-07-02)
Glycan recognition is typically studied using free glycans, but glycopeptide presentations represent more physiological conditions for glycoproteins. To facilitate studies of glycopeptide recognition, we developed Glyco-SPOT synthesis, which enables the parallel production of diverse glycopeptide libraries at microgram scales. The
Caiyi C Li et al.
PLoS biology, 13(10), e1002269-e1002269 (2015-10-07)
Sepsis, an exaggerated systemic inflammatory response, remains a major medical challenge. Both hyperinflammation and immunosuppression are implicated as causes of morbidity and mortality. Dendritic cell (DC) loss has been observed in septic patients and in experimental sepsis models, but the
A L Mayburd et al.
Archives of biochemistry and biophysics, 378(1), 40-44 (2000-06-28)
An unusual complex has been observed between the common electrophoresis tracer bromophenol blue (BPB) and the cytochrome c' from Chromatium vinosum during polyacrylamide gel electrophoresis. Complex formation results in a shift and increase in the intensity of the visible absorption
Marion Cortier et al.
Oncotarget, 6(9), 6877-6886 (2015-03-13)
High doses of the organic nitrate glyceryl trinitrate (GTN), a nitric oxide (NO) donor, are known to trigger apoptosis in human cancer cells. Here, we show that such a cytotoxic effect can be obtained with subtoxic concentrations of GTN when
Takaya Shimura et al.
Cancer prevention research (Philadelphia, Pa.), 8(3), 240-248 (2015-01-17)
Although the early diagnosis of gastric cancer provides the opportunity for curative endoscopic resection, comprehensive screening endoscopy would be invasive and expensive. To date, there is a complete absence of clinically useful gastric cancer biomarkers. With the goal of discovering
Mayra Denisse Ramírez-Quijas et al.
Microbial pathogenesis, 87, 1-12 (2015-07-19)
In order for Candida species to adhere and colonize human host cells they must express cell wall proteins (CWP) and adapt to reactive oxygen species (ROS) generated by phagocytic cells of the human host during the respiratory burst. However, how
Carlos Eduardo Braga de Abreu et al.
Plant cell reports, 33(8), 1289-1306 (2014-04-29)
Cowpea cultivars differing in salt tolerance reveal differences in protein profiles and adopt different strategies to overcome salt stress. Salt-tolerant cultivar shows induction of proteins related to photosynthesis and energy metabolism. Salinity is a major abiotic stress affecting plant cultivation
Susanne Mueller et al.
Molecular biology of the cell, 26(14), 2596-2608 (2015-05-23)
Protein degradation is essential for cellular homeostasis. We developed a sensitive approach to examining protein degradation rates in Saccharomyces cerevisiae by coupling a SILAC approach to selected reaction monitoring (SRM) mass spectrometry. Combined with genetic tools, this analysis made it
Shaoping Wu et al.
Gut, 64(7), 1082-1094 (2014-08-01)
Vitamin D and the vitamin D receptor (VDR) appear to be important immunological regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been implicated in IBD, where interestingly, polymorphisms of genes such as ATG16L1 have been associated with increased
Xian-Jun Sun et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(2), 707-718 (2015-09-12)
The microRNA (miR) 29 family has been studied extensively for its involvement in several diseases, and aberrant expression of its members is associated with tumorigenesis and cancer progression. Here, we examined the role of miR-29a in pancreatic cancer and the
Miroslaw Ksiazek et al.
Biological chemistry, 396(3), 261-275 (2014-11-14)
The genome of Tannerella forsythia, an etiological factor of chronic periodontitis, contains several genes encoding putative proteases. Here, we characterized a subtilisin-like serine protease of T. forsythia referred to as mirolase. Recombinant full-length latent promirolase [85 kDa, without its signal
Harris Pratsinis et al.
BioMed research international, 2015, 427138-427138 (2015-11-20)
Intervertebral disc (IVD) degeneration is strongly associated with low back pain, a major cause of disability worldwide. An in-depth understanding of IVD cell physiology is required for the design of novel regenerative therapies. Accordingly, aim of this work was the
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