Emily Miedel et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(6), 935-943 (2013-01-03)
Thrombospondin-2 (TSP2) is a matricellular protein that is highly up-regulated during fracture healing. TSP2 negatively regulates vascularity, vascular reperfusion following ischemia, and cutaneous wound healing. As well, TSP2-null mice show increased endocortical bone formation due to an enhanced number of