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Evaluation of worker exposure to TDI, MOCA, and methylene chloride.
Richard Fairfax et al.
Journal of occupational and environmental hygiene, 3(6), D50-D53 (2006-04-20)
P Vineis et al.
Cancer causes & control : CCC, 8(3), 346-355 (1997-05-01)
Epidemiological evidence on the relation between aromatic amines and cancer risk is reviewed. In particular, cancer risk in humans resulting from exposure to aromatic amines from occupational sources and tobacco smoking is assessed with reference to ecologic, cohort, and case-control
A Jeżewska et al.
Toxicology mechanisms and methods, 21(7), 554-560 (2011-04-09)
A new procedure has been developed for the assay of 2,2'-dichloro-4,4'-methylenedianiline (MOCA) using high-performance liquid chromatography with diode array detector. MOCA was sampled from workplace air and derivative before determination using 3,5-dinitrobenzoyl chloride. The determination was carried out in the
Hong-I Chen et al.
Urology, 66(2), 305-310 (2005-08-16)
Transitional cell carcinoma of the urinary bladder is associated with occupational exposure to 4,4'-methylenebis(2-chloroaniline) (MBOCA). A program to monitor MBOCA levels in the work environment and to screen for bladder cancer was performed at four MBOCA manufacturing factories. The U.S.
T M Reid et al.
Toxicology letters, 95(3), 205-210 (1998-08-15)
The genotoxic potential of two occupationally significant chemicals, 4,4'-methylene-bis-2-chloroaniline (MOCA) and 2-phenyl-1,4-benzoquinone (PBQ), was explored by monitoring the induction of mutations at the HPRT locus of AHH-1 human lymphoblastoid cells. Exposure of AHH-1 cells to the putative carcinogenic metabolite of
Bogusław Buszewski et al.
Talanta, 93, 117-121 (2012-04-10)
Extraction techniques for 4,4'-methylenebis(2-chloroaniline) (MOCA) in air samples and water solutions were developed and compared. Classic techniques for air sampling of MOCA were enhanced by incorporating a derivatization step (3,5-dinitrobenzoyl chloride solution in toluene), thus increasing the limit of detection
J Cocker et al.
The Annals of occupational hygiene, 53(5), 499-507 (2009-05-19)
The main objective of the study was to gather information about the current controls and levels of exposure to 4,4'-methylene-bis (2-chloroaniline) (MbOCA) in a representative cross section of workplaces that use it to manufacture polyurethane elastomers. The study also aimed
A Robert et al.
International archives of occupational and environmental health, 72(4), 229-237 (1999-09-24)
The objectives of the study were to investigate the best urinary marker of exposure to MOCA in urine samples of exposed workers and to study its applicability in exposure evaluation in polyurethane resin production plants. In addition, our intention was
M Schuler et al.
Mutation research, 392(1-2), 81-95 (1997-08-01)
The in vitro micronucleus assay in conjunction with CREST-staining and fluorescence in situ hybridization (FISH) with centromere-specific DNA probes is being increasingly utilized for the detection of clastogenic and aneuploidy-inducing agents. Although potentially powerful techniques, both methods have unique characteristics
L Luukkanen et al.
Pharmacology & toxicology, 80(3), 152-158 (1997-03-01)
Rats were treated with acetone, pyrazole, phenobarbital, 4,4'-methylenebis-(2-chloroaniline) (MOCA), 3-methylcholanthrene, creosote oil, or a mixture of polychlorinated biphenyls (Aroclor 1254) to study the inducibility and enzyme kinetics of UDP-glucuronosyltransferases towards 1-hydroxypyrene, which is a human metabolite and a urinary biomarker
Wei-Chung Shih et al.
Rapid communications in mass spectrometry : RCM, 21(24), 4073-4078 (2007-11-17)
Analysis of 4,4'-methylenebis(2-cholroaniline) (MOCA) or its metabolites in urine has been considered as the appropriate method to assess MOCA exposures through inhalation and skin absorption. MOCA and its metabolite, N-acetyl 4,4'-methylenebis(2-chloroaniline) (acetyl-MOCA), are analyzed using methods either limited by sensitivity
E B Murray et al.
Reviews on environmental health, 20(3), 163-176 (2005-12-13)
Cytogenetic end-points used to estimate risk of genotoxic events in workers include the measurement of micronuclei (MN) in exfoliated cells, lymphocytes, and other tissues. Micronuclei are chromatin-containing bodies outside the cell nucleus resulting from contaminant-induced DNA damage. A review of
4,4'-Methylenebis(2-chloroaniline).
Report on carcinogens : carcinogen profiles, 10, 149-151 (2004-08-26)
Hong-I Chen et al.
Journal of occupational health, 49(5), 389-398 (2007-10-24)
Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between
Carmen E Perrone et al.
Archives of toxicology, 78(10), 589-598 (2004-05-29)
Avian embryos are a potential alternative model for chemical toxicity and carcinogenicity research. Because the toxic and carcinogenic effects of some chemicals depend on bioactivation, activities of biotransformation enzymes and formation of DNA adducts in embryonic turkey liver were examined.
A Robert et al.
International archives of occupational and environmental health, 72(4), 223-228 (1999-09-24)
The objective of the study was to validate a new and simple method to determine MOCA in the urine of exposed workers. The separation, identification and quantification of urinary MOCA were performed in spiked urines by a sensitive and practical
4,4'-Methylenebis(2-chloroaniline).
Report on carcinogens : carcinogen profiles, 11, III167-III168 (2004-01-01)
[Resolution of overlapping mass spectra of azobiphenyl dyes by subwindow factor analysis technique].
X G Shao et al.
Se pu = Chinese journal of chromatography, 19(2), 184-187 (2003-01-25)
Subwindow factor analysis(SWFA) has been proven to be an effective data processing technique. In this paper, it is applied to the resolution of overlapping GC-MS peaks. A two-component sample of azobiphenyl dyes (3,3'-dichlorobenzidine, 4,4'-methylene-bis-(2-chloroaniline)) was prepared and a data set
4,4'-Methylenebis(2-chloroaniline).
Report on carcinogens : carcinogen profiles, 12, 262-264 (2011-08-24)
C Keen et al.
Toxicology letters, 213(1), 3-8 (2011-04-20)
This is a follow up survey of exposure to 4,4'-methylene-bis(2-chloroaniline) (MbOCA) and isocyanates in the UK polyurethane industry. Urine samples (n=446) were collected from 90 different workers. MbOCA levels were below the limit of detection in 170 samples and 26
J Cocker et al.
International journal of hygiene and environmental health, 210(3-4), 383-386 (2007-02-27)
The UK Health and Safety Laboratory (HSL) provides research and analytical support to the Health and Safety Executive, other Government Departments and employers. In the area of biomonitoring HSL conducts research studies and provides an analytical service for regular surveillance
Abid Dost et al.
Occupational medicine (Oxford, England), 59(6), 402-405 (2009-07-01)
To monitor the occurrence of cancer in a recently defined cohort of UK workers engaged in the manufacture of polyurethane elastomers using 4,4'-methylene-bis-ortho-chloroaniline. A cohort of 308 male production workers from seven factories have been enumerated. All employees had a
R E Savage et al.
Journal of occupational and environmental medicine, 40(2), 125-135 (1998-03-21)
Many bladder cancers are indolent, and since there are no biomarkers to predict progression, the prognosis is problematic. Utilizing an in vitro/in vivo human uroepithelial cell (SV-HUC.PC) transformation system, we investigated several molecular events occurring along the continuum of exposure
E B Murray et al.
Mutation research, 446(2), 175-180 (2000-01-15)
4,4'-Methylenebis-(2-chloroaniline) (MOCA) is used in the manufacture of polyurethane. The IARC classifies MOCA as a probable human carcinogen. Suggested changes to guidelines for health surveillance of MOCA-exposed workers in Australia include a reduction in acceptable levels of urinary MOCA to
Chiu-Shong Liu et al.
Environmental health perspectives, 113(6), 771-774 (2005-06-03)
A 52-year-old male chemical worker was admitted to the hospital with a history of paroxysmal microscopic hematuria for about 2 years and nocturia with gross hematuria about five times per night for 2 months. He was a nonsmoker and denied
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