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Ryan L McKimmie et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(9), G620-G627 (2013-09-07)
Intestinal fat absorption is known to be, overall, a highly efficient process, but much less is known about the efficiency with which individual dietary fatty acids (FA) are absorbed by the adult small intestine. We therefore measured the absorption efficiency
Biranchi Bebarta et al.
Food chemistry, 136(2), 889-894 (2012-11-06)
Medium chain (MC) and behenic fatty acids were incorporated into kokum, sal and mango fats using 1,3-specific lipase catalysed acidolysis. The incorporation of fatty acids increased with increase in concentration of fatty acids and duration of reaction. The order of
Nicol Kruska et al.
Biochimica et biophysica acta, 1852(5), 925-936 (2015-01-15)
X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder resulting from defective ABCD1 transport protein. ABCD1 mediates peroxisomal uptake of free very-long-chain fatty acids (VLCFA) as well as their CoA-esters. Consequently, VLCFA accumulate in patients' plasma and tissues, which is considered
Balasubiramanian Kamatchi Kala et al.
International journal of food sciences and nutrition, 61(5), 497-511 (2010-02-05)
Three accessions of the under-utilized legume itching bean (Mucuna pruriens var. pruriens) were analysed for proximate composition, mineral profiles, vitamins (niacin and ascorbic acid), fatty acid profiles, amino acid profiles of total seed protein, in vitro protein digestibility and certain
Lais Alonso et al.
International journal of pharmaceutics, 434(1-2), 391-398 (2012-06-14)
Miltefosine (MT) is an alkylphospholipid approved for breast cancer metastasis and visceral leishmaniasis treatments, although the respective action mechanisms at the molecular level remain poorly understood. In this work, the interaction of miltefosine with the lipid component of stratum corneum
Jaleh Varshosaz et al.
Acta pharmaceutica (Zagreb, Croatia), 62(1), 31-44 (2012-04-05)
The objective of this work was to study the effect of fatty acid chain length grafted to methoxy poly(ethylene glycol) (mPEG) on self assembling properties of micelles for etoposide delivery. Three amphiphilic copolymers were synthesized using mPEG, myristic acid, stearic
Oswald Quehenberger et al.
Journal of lipid research, 51(11), 3299-3305 (2010-07-31)
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test
Krishna Rao Maddipati et al.
Prostaglandins & other lipid mediators, 94(1-2), 59-72 (2011-01-18)
Bioactive lipids derived from polyunsaturated fatty acids constitute an important set of lipid mediators with diverse homeostatic and pathophysiological activities. The role of bioactive lipids in inflammation, active resolution of inflammation, reproduction, cardiovascular biology, chronic diseases such as cancer and
J Davidson et al.
British journal of pharmacology, 166(4), 1193-1210 (2012-03-01)
Disruptions of cell death signalling occur in pathological processes, such as cancer and degenerative disease. Increased knowledge of cell death signalling has opened new areas of therapeutic research, and identifying key mediators of cell death has become increasingly important. Early
Wei Xie et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 31(10), 1510-1512 (2009-02-24)
To study the chemical constituents of Smallanthus sonchifolius. Chemical constituents were separated through chromatographic methods and their structures were elucidated by spectral analysis. Seven compounds were isolated from the chloroform fraction of 75% alcohol extract from the leaves of Smallanthus
Ofentse Mazimba et al.
Bioorganic & medicinal chemistry, 19(17), 5225-5230 (2011-08-05)
The investigation of Tylosema esculentum (Morama) husks, cotyledons, and tuber yielded griffonilide 2, compound 1, griffonin 3, gallic acid 4, protocatechuic acid 5, β-sitosterol 6, behenic acid 7, oleic acid 8, sucrose 9, 2-O-ethyl-α-D-glucopyranoside 10, kaempferol 11 and kaempferol-3-O-β-D-glucopyranoside 12.
Yin Ning Chiang et al.
PLoS genetics, 12(6), e1006126-e1006126 (2016-06-23)
Many of the lipids found on the cuticles of insects function as pheromones and communicate information about age, sex, and reproductive status. In Drosophila, the composition of the information-rich lipid profile is dynamic and changes over the lifetime of an
Jomjai Peerapattana et al.
Bio-medical materials and engineering, 14(3), 293-301 (2004-08-10)
This study aimed to prepare a colon drug delivery system using dry-coated time-controlled disintegration wax matrix tablets. Indomethacin was used as a model drug. Behenic acid and lactose were used as coating materials. The effects of lactose content and pH
N B Cater et al.
The American journal of clinical nutrition, 73(1), 41-44 (2000-12-22)
Dietary behenic acid (22:0) is poorly absorbed. Because of its low bioavailability compared with other fatty acids and because of its very long chain length, the effect of dietary behenic acid (behenate) on serum lipid concentrations in humans is assumed
Mojgan Masoodi et al.
Rapid communications in mass spectrometry : RCM, 22(2), 75-83 (2007-12-07)
Bioactive lipid mediators derived from polyunsaturated fatty acids (PUFA) exhibit a range of tissue- and cell-specific activities in many physiological and pathological processes. Electrospray ionisation tandem mass spectrometry coupled to liquid chromatography (LC/ESI-MS/MS) is a sensitive, versatile analytical methodology for
Xiao-mei Wang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(6), 891-893 (2011-10-25)
To study the chemical constituents of Phellinus lonicerinus. The constituents were seperated and purified by silica column chromatography, Sephadex LH-20 and other column chromatography, then their structures were identified by spectral methods. Six compounds were isolated and identified as ergosta-6,22-dien-3beta
Jill Dorsey et al.
Journal of pediatric gastroenterology and nutrition, 50(4), 441-446 (2010-02-25)
The gold standard for the diagnosis of fat malabsorption, the 72-hour fat balance study, requires a 3-day collection to generate a coefficient of fat absorption (CFA). We hypothesized that a new test using behenic acid (behenate test) as a nonabsorbable
Yunbao Liu et al.
Journal of natural products, 73(7), 1193-1195 (2010-06-23)
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of established in vitro cell viability assays. An antioxidant assay
Wei-Yi Hsu et al.
Analytical chemistry, 82(16), 6814-6820 (2010-08-14)
Peroxisomal disorders are characterized biochemically by elevated levels of very long chain fatty acids (VLCFAs) in serum. Herein, we describe a novel approach for quantification of VLCFAs in serum, namely, eicosanoic acid (C20:0), docosanoic acid (C22:0), tetracosanoic acid (C24:0), and
Christoph Wiesinger et al.
The Journal of biological chemistry, 288(26), 19269-19279 (2013-05-15)
X-linked adrenoleukodystrophy (X-ALD), an inherited peroxisomal disorder, is caused by mutations in the ABCD1 gene encoding the peroxisomal ATP-binding cassette (ABC) transporter ABCD1 (adrenoleukodystrophy protein, ALDP). Biochemically, X-ALD is characterized by an accumulation of very long-chain fatty acids and partially
I Rajkovic et al.
Physical review letters, 104(12), 125503-125503 (2010-04-07)
In this Letter, we report the pioneering use of free electron laser radiation for the investigation of periodic crystalline structures. The diffraction properties of silver behenate single nanocrystals (5.8 nm periodicity) with the dimensions of 20 nm x 20 nm
Laura Bannach Jardim et al.
Brain & development, 32(3), 180-190 (2009-03-10)
X-linked adenoleukodystrophy is a genetic disease that affects the degradation of very long-chain fatty acids. In male patients, common pictures are the cerebral form (CALD), myeloneuropathy (AMN), and Addison-only. To describe the clinical course of affected male patients from South
Marian L Neuhouser et al.
Public health nutrition, 6(7), 703-709 (2003-10-14)
To examine associations of biomarkers of nutrient intake with overall diet quality. A convenience sample of 102 healthy postmenopausal women in Seattle, Washington (USA). Participants attended a study centre where they provided fasting blood specimens and completed a 122-item validated
Evaluation of diagnostic markers for measles virus infection in the context of an outbreak in Spain.
María M Mosquera et al.
Journal of clinical microbiology, 43(10), 5117-5121 (2005-10-07)
A measles outbreak occurred from January to July 2003 in Spain, despite the fact that the Plan of Eradication of Measles and its surveillance program had been set up in 2001. Different diagnostic markers for measles virus infection were compared
Sophie Cantin et al.
Langmuir : the ACS journal of surfaces and colloids, 26(2), 830-837 (2009-09-02)
The structure of docosanoic acid monolayers spread over chloride salt solutions of copper was investigated by means of isotherm measurements, grazing incidence X-ray diffraction, and Brewster angle microscopy, as a function of the ion concentration and at two subphase pHs
Mohammad Hossein Morowvat et al.
Bioresource technology, 101(6), 2059-2062 (2009-12-01)
The production of biodiesel from a naturally isolated strain of Chlamydomonas was investigated. The microalgal strain was isolated from the rice paddy-field soil samples during a screening program. The identification was done using physiological and molecular approaches. After reaching the
High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography-mass spectrometry.
Quehenberger O, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1811(11), 648-656 (2011)
Han-shen Zhen et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 33(5), 717-719 (2010-09-30)
To study the chemical constituents of the petroleum ether portion of Nervilia fordii. The constituents were separated and purified by using column chromatography with silica gel. These compounds were identified by their physical and spectral data. Six compounds were isolated
Tang-Chia Chung et al.
Analytica chimica acta, 611(1), 113-118 (2008-02-27)
Docosanoic (C22), tetracosanoic (C24) and hexacosanoic (C26) acids are saturated very-long-chain fatty acids (VLCFA) present at trace levels in biosamples. VLCFA can be used as potential biomarkers for the diagnosis of hereditary diseases such as X-linked adrenoleukodystrophy. Because the analytes
Torben H Jensen et al.
Physics in medicine and biology, 56(6), 1717-1726 (2011-02-25)
We demonstrate high-resolution small-angle x-ray scattering computed tomography (SAXS-CT) of soft matter and soft tissue samples. Complete SAXS patterns over extended ranges of momentum transfer are reconstructed spatially resolved from volumes inside an extended sample. Several SAXS standard samples are
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