12024AST

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Chiral separation of thiazide diuretics by HPLC on Chiralcel OD-RH, Chiralcel OJ-R and Chirobiotic-T phases.

Balázs Visegrády et al.

Journal of biochemical and biophysical methods, 53(1-3), 15-24 (2002-10-31)

This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R) and teicoplanin (Chirobiotic T) phases. All columns showed good chiral recognition ability for this class of compounds. Out

Super/subcritical fluid chromatography chiral separations with macrocyclic glycopeptide stationary phases.

Ying Liu et al.

Journal of chromatography. A, 978(1-2), 185-204 (2002-12-03)

The chiral recognition capabilities of three macrocyclic glycopeptide chiral selectors, namely teicoplanin (Chirobiotic T), its aglycone (Chirobiotic TAG) and ristocetin (Chirobiotic R), were evaluated with supercritical and subcritical fluid mobile phases. A set of 111 chiral compounds including heterocycles, analgesics

Chromatographic Separations and Analysis: Macrocyclic Glycopeptide Chiral Stationary Phases

Berthod, A.

Comprehensive Chirality, 8, 227-262 (2012)

Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core.

Felikss Mutulis et al.

Bioorganic & medicinal chemistry, 15(17), 5787-5810 (2007-07-10)

Two hundred and ten tertiary amides were prepared on solid phase. Diamines were coupled to activated carboxylated Wang polymer, and the polymeric substituted benzyloxycarbonyl protected diamines obtained were reacted with aldehydes or ketones in trimethyl orthoformate giving resin attached Schiff

Insights into the retention mechanism of neutral organic compounds on polar chemically bonded stationary phases in reversed-phase liquid chromatography.

Zahid Ali et al.

Journal of chromatography. A, 1052(1-2), 199-204 (2004-11-06)

The solvation parameter model is used to characterize the retention properties of a 3-aminopropylsiloxane-bonded (Alltima amino), three 3-cyanopropylsiloxane-bonded (Ultrasphere CN, Ultremex-CN and Zorbax SB-CN), a spacer bonded propanediol (LiChrospher DIOL) and a multifunctional macrocyclic glycopeptide (Chirobiotic T) silica-based stationary phases

Enantioseparation and chiral recognition mechanism of new chiral derivatives of xanthones on macrocyclic antibiotic stationary phases.

Carla Fernandes et al.

Journal of chromatography. A, 1241, 60-68 (2012-05-04)

A chiral HPLC method using four macrocyclic antibiotic chiral stationary phases (CSPs) has been investigated for determination of the enantiomeric purity of fourteen new chiral derivatives of xanthones (CDXs). The separations were performed with the CSPs Chirobiotic T, Chirobiotic TAG

Enantiomeric impurities in chiral catalysts, auxiliaries, and synthons used in enantioselective syntheses. Part 4

Qui, Haiziao, et al.

Tetrahedron Asymmetry, 24 (18), 1134-1141 (2013)

High-performance liquid chromatographic enantioseparation of bicalutamide and its related compounds.

Roland Török et al.

Journal of chromatography. A, 1098(1-2), 75-81 (2005-11-30)

Direct high-performance liquid chromatographic methods were developed for the enantioseparation of (R,S)-bicalutamide (1) and its analogs (+/-)-3-chloro-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide (2), (+/-)-N-(4-cyano-3-(trifluoro-methyl)phenyl)-2-methyloxirane-2-carboxamide (3), (+/-)-4-fluorophenylsulfonyl-2-hydroxy-2-methylpropionic acid (4) and (+/-)-3-hydroxy-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide (5). The methods involved the use of a cellulose-based Chiralcel OD-H, macrocyclic glycopeptide-based Chirobiotic T

High-performance liquid chromatographic enantioseparation of monoterpene-based 2-amino carboxylic acids on macrocyclic glycopeptide-based phases.

László Sipos et al.

Journal of chromatography. A, 1217(44), 6956-6963 (2010-09-25)

The enantiomers of five monoterpene-based 2-amino carboxylic acids were directly separated on chiral stationary phases containing macrocyclic glycopeptide antibiotics such as teicoplanin (Astec Chirobiotic T and T2) and teicoplanin aglycone (Chirobiotic TAG) as chiral selectors. The effects of pH, the

Enantiomeric separation of metoprolol and alpha-hydroxymetoprolol by liquid chromatography and fluorescence detection using a chiral stationary phase.

B Mistry et al.

Journal of chromatography. B, Biomedical sciences and applications, 758(2), 153-161 (2001-08-07)

A sensitive and stereoselective high-performance liquid chromatographic assay for the determination of the enantiomers of metoprolol (R- and S-) and the diastereoisomers of alpha-hydroxymetoprolol (IIA, IIB) in plasma is reported. Chromatography involved direct separation of enantiomers using a Chirobiotic T

Enantioselective high-performance liquid chromatographic method for the determination of baclofen in human plasma.

Mohamed M Hefnawy et al.

Talanta, 61(5), 667-673 (2008-10-31)

A new analytical method for the separation and determination of R-(-)- and S-(+)- baclofen enantiomers in human plasma by high-performance liquid chromatography (HPLC) with UV detection was developed. Enantioselective resolution of the baclofen enantiomers was achieved by using teicoplanin macrocyclic

High-performance liquid chromatographic enantioseparation of beta-amino acids.

A Péter et al.

Journal of chromatography. A, 926(2), 229-238 (2001-09-15)

Direct and indirect high-performance liquid chromatographic methods were developed for the enantioseparation of beta-amino acids (beta-substituted-beta-alanines). Direct separation involved the application of chiral columns: Crownpak CR(+), Chirobiotic T and Chirobiotic R. Indirect separation was based on precolumn derivatization with 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl

Chromatography Liquid Chiral Separations

Xiao, T.L., et al.

Encyclopedia of Separation Science, 1-15 (2000)

High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.

Róbert Berkecz et al.

Journal of chromatography. A, 1216(6), 927-932 (2008-12-27)

The direct separation of the enantiomers of four 2-aminomono- or dihydroxycyclopentanecarboxylic acids and four 2-aminodihydroxycyclohexanecarboxylic acids was performed on chiral stationary phases containing macrocyclic glycopeptide antibiotics such as teicoplanin (Astec Chirobiotic T and T2), teicoplanin aglycone (Chirobiotic TAG) or ristocetin

Methotrexate determination in pharmaceuticals by enantioselective HPLC.

D Abd el-Hady et al.

Journal of pharmaceutical and biomedical analysis, 37(5), 919-925 (2005-05-03)

A simple, sensitive and selective high performance liquid chromatographic method with UV detection for the chiral separation of racemic methotrexate (rac-Mtx) and enantiomeric purity of L-methotrexate in pharmaceutical formulations was developed and validated. The chiral separation was optimized studying both

Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma.

Berit P Jensen et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 865(1-2), 48-54 (2008-03-07)

A stereoselective liquid chromatography-tandem mass spectrometry assay was developed and validated for quantification of S- and R-metoprolol at concentrations of 0.5-50 microg/L in human plasma. Metoprolol was extracted from plasma by liquid-liquid extraction with ethyl acetate (82% recovery). Chromatographic separation

Comparative study of the instrumental couplings of high performance liquid chromatography with microwave-assisted digestion hydride generation atomic fluorescence spectrometry and inductively coupled plasma mass spectrometry for chiral speciation of selenomethionine in breast and formula milk

Gomez-Ariza, J.L,, et al.

Analytica Chimica Acta, 520 (1-2), 229-235 (2004)

Shortcut method for evaluation and design of a hybrid process for enantioseparations.

Malte Kaspereit et al.

Journal of chromatography. A, 1092(1), 43-54 (2005-09-29)

Hybrid processes for enantioseparations have a considerable potential for reducing investment and operational costs. An example is the combination of simulated moving bed (SMB) chromatography and selective crystallisation. However, the design of integrated processes is a difficult task. A shortcut

Recent advances in the direct and indirect liquid chromatographic enantioseparation of amino acids and related compounds: a review.

István Ilisz et al.

Journal of pharmaceutical and biomedical analysis, 69, 28-41 (2012-02-22)

Amino acids are essential for life, and have many functions in metabolism. One particularly important function is to serve as the building blocks of peptides and proteins, giving rise to complex three dimensional structures through disulfide bonds or crosslinked amino

Chiral speciation of selenoamino acids in biological samples.

Beibei Chen et al.

Journal of chromatography. A, 1363, 62-70 (2014-08-19)

In this paper, the "state of the art" of chiral speciation of selenoamino acids (SeAAs) in biological samples is critically reviewed. The significance and the features of such studies are highlighted. A special focus lies on chiral speciation of SeAAs

Effects of a strongly adsorbed additive on process performance in chiral preparative chromatography.

P Forssén et al.

Journal of chromatography. A, 1212(1-2), 89-97 (2008-10-31)

The shapes of elution profiles are often significantly influenced by the presence of strongly adsorbed additives in the mobile phase. This aspect needs to be considered in quantitative optimization of preparative chromatography. The theoretical study carried out here is based

Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry.

Xingxing Diao et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 939, 67-72 (2013-10-10)

A novel and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to determine the exposure of 3-n-butylphthalide (NBP) enantiomers in human plasma. The NBP enantiomers were extracted from human plasma using methyl tert-butyl ether. The baseline separation

Enantioselective high-performance liquid chromatographic separation of N-methyloxycarbonyl unsaturated amino acids on macrocyclic glycopeptide stationary phases.

J M M Boesten et al.

Journal of chromatography. A, 1108(1), 26-30 (2006-01-31)

This paper describes the enantiomeric resolution of a series of unsaturated N-methyloxycarbonyl-alpha-H-alpha-amino acids (N-MOC-alpha-amino acids) on macrocyclic glycopeptide stationary phases by means of high-performance liquid chromatography (HPLC). Three types of glycopeptide phases, i.e. Chirobiotic T, V and R, were evaluated

Natural terpene derivatives as new structural task-specific ionic liquids to enhance the enantiorecognition of acidic enantiomers on teicoplanin-based stationary phase by high-performance liquid chromatography.

Jolanta Flieger et al.

Journal of separation science, 40(11), 2374-2381 (2017-04-21)

We present the specific cooperative effect of a semisynthetic glycopeptide antibiotic teicoplanin and chiral ionic liquids containing the (1R,2S,5R)-(-)-menthol moiety on the chiral recognition of enantiomers of mandelic acid, vanilmandelic acid, and phenyllactic acid. Experiments were performed chromatographically on an

Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry

Diao, Xingxing, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 939, 67-72 (2013)

Enantioselective analysis of (R)- and (S)-atenolol in urine samples by a high-performance liquid chromatography column-switching setup.

G Lamprecht et al.

Journal of chromatography. B, Biomedical sciences and applications, 740(2), 219-226 (2000-05-23)

An HPLC column-switching method for the enantioselective determination of (R,S)-atenolol in human urine was developed and validated. Diluted urine samples were injected onto a LiChrospher ADS restricted access column and atenolol was separated from most of the matrix components using

High-performance liquid chromatographic enantioseparation of unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids on macrocyclic glycopeptide-based chiral stationary phases.

László Sipos et al.

Journal of chromatography. A, 1232, 142-151 (2011-12-20)

The enantiomers of four unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids were directly separated on chiral stationary phases containing macrocyclic glycopeptide antibiotics teicoplanin (Astec Chirobiotic T and T2), teicoplanin aglycone (Chirobiotic TAG), vancomycin (Chirobiotic V) and vancomycin aglycone (Chirobiotic VAG) as chiral selectors.

Syntheses of racemic and non-racemic silicon- and germanium-containing a-amino acids of the formula type H2NCH(CH2ElR3)COOH (El=Si, Ge; R=organyl) and incorporation of d-H2NCH(CH2SiMe3)COOH and d-H2NCH(CH2GeMe3)COOH into biologically active decapeptides: a study on C/Si/Ge bioisosterism

Merget, Markus, et al.

Journal of Organometallic Chemistry, 628 (2), 183-194 (2001)

Comparative HPLC methods for β-blockers separation using different types of chiral stationary phases in normal phase and polar organic phase elution modes. Analysis of propranolol enantiomers in natural waters.

Sonia Morante-Zarcero et al.

Journal of pharmaceutical and biomedical analysis, 62, 33-41 (2012-01-24)

The enantioselectivities of β-blockers (propranolol, metoprolol, atenolol and pindolol) on four different types of chiral stationary phases (CSPs): Chiralpak AD-H, Lux Cellulose-1, Chirobiotic T and Sumichiral OA-4900 were compared using polar organic (PO) elution mode and normal phase (NP) elution

Enantioselective separation of unusual amino acids by high performance liquid chromatography

Kucerova, Gabriela, et al.

Separation and Purification Technology, 119, 123-128 (2013)

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