122-62-3

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An insertion/deletion polymorphism at the microRNA-122 binding site in the interleukin-1α 3'-untranslated region is associated with a risk for osteoarthritis.

Fan Yang et al.

Molecular medicine reports, 12(4), 6199-6206 (2015-08-05)

Polymorphisms located at microRNA (miRNA) binding sites may affect the expression of genes. The present study aimed to identify the association between an insertion/deletion (Ins/Del) polymorphism (rs3783553) in the 3'‑untranslated region (3'‑UTR) of interleukin‑1α (IL‑1A) and the risk for osteoarthritis

Cellular cofactors affecting hepatitis C virus infection and replication.

Glenn Randall et al.

Proceedings of the National Academy of Sciences of the United States of America, 104(31), 12884-12889 (2007-07-10)

Recently identified hepatitis C virus (HCV) isolates that are infectious in cell culture provide a genetic system to evaluate the significance of virus-host interactions for HCV replication. We have completed a systematic RNAi screen wherein siRNAs were designed that target

Utility of Stimulated Thyroglobulin in Reclassifying Low Risk Thyroid Cancer Patients' Following Thyroidectomy and Radioactive Iodine Ablation: A 7-Year Prospective Trial.

Anwar A Jammah et al.

Frontiers in endocrinology, 11, 603432-603432 (2021-03-16)

Following total thyroidectomy and radioactive iodine (RAI) ablation, serum thyroglobulin levels should be undetectable to assure that patients are excellent responders and at very low risk of recurrence. To assess the utility of stimulated (sTg) and non-stimulated (nsTg) thyroglobulin levels

Characterisation of 96 mutations in 128 unrelated severe haemophilia A patients from France. Description of 62 novel mutations.

Christine Vinciguerra et al.

Thrombosis and haemostasis, 95(4), 593-599 (2006-04-08)

Direct sequencing of the coding region of factor VIII (F8) gene was used to determine the mutations responsible for severe haemophilia A (FVIII<1%) in 128 unrelated haemophiliacs A, negative for intron 22 and intron 1 inversions. A mutation was found

C-reactive protein 3' UTR +1444C>T polymorphism in patients with spontaneous venous thromboembolism.

R Vormittag et al.

Atherosclerosis, 188(2), 406-411 (2005-12-15)

Data on C-reactive protein (CRP) as a risk indicator of venous thromboembolism are conflicting. A recent study reported higher CRP levels in homozygous carriers of a novel CRP gene polymorphism at the 3' UTR (CRP +1444C>T). We investigated, whether homozygosity

Glycemic control and survival of diabetic hemodialysis patients--importance of lower hemoglobin A1C levels.

E Ishimura et al.

Diabetes research and clinical practice, 83(3), 320-326 (2009-01-13)

The significance of hemoglobin A1C (HbA1C) on the survival of diabetic hemodialysis patients still remains controversial. We investigated the impact of HbA1C on the survival. A total of 122 diabetic patients on maintenance hemodialysis (age, 59.9+/-11.9 years [mean+/-SD]; hemodialysis duration:

DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection.

Todd M Everson et al.

Genome medicine, 7, 89-89 (2015-08-22)

The prevalence of allergic diseases are increasing worldwide, emphasizing the need to elucidate their pathogeneses. The aims of this study were to use a two-stage design to identify DNA methylation levels at cytosine-phosphate-guanine (CpG) sites across the genome associated with

Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.

Andrei V Ougolkov et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 12(17), 5074-5081 (2006-09-05)

We have shown recently that glycogen synthase kinase-3 (GSK-3) beta regulates nuclear factor-kappaB (NF-kappaB)-mediated pancreatic cancer cell survival and proliferation in vitro. Our objective was to determine the localization of GSK-3beta in pancreatic cancer cells and assess the antitumor effect

NANOG modulates stemness in human colorectal cancer.

J Zhang et al.

Oncogene, 32(37), 4397-4405 (2012-10-23)

NANOG is a stem cell transcription factor that is essential for embryonic development, reprogramming normal adult cells and malignant transformation and progression. The nearly identical retrogene NANOGP8 is expressed in multiple cancers, but generally not in normal tissues and its

Isotope concentrations from 24-h urine and 3-h serum samples can be used to measure intestinal magnesium absorption in postmenopausal women.

Karen E Hansen et al.

The Journal of nutrition, 144(4), 533-537 (2014-02-07)

Studies suggest a link between magnesium status and osteoporosis. One barrier to more conclusive research on the potential relation is measuring intestinal magnesium absorption (MgA), which requires the use of stable isotopes and a ≥6-d stool or 3-d urine collection.

Exclusion of the ACE D/I gene polymorphism as a determinant of endothelial dysfunction.

G P Rossi et al.

Hypertension (Dallas, Tex. : 1979), 37(2), 293-300 (2001-03-07)

A deletion/insertion (D/I) polymorphism within the ACE gene may increase the risk of cardiovascular events through still unknown mechanisms. The latter may involve increased angiotensin II-induced NO breakdown and/or reduced agonist-mediated NO release. We therefore investigated whether the D allele

Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine effects of transforming growth factor beta and connective tissue growth factor.

Jonathan Slawik et al.

European journal of heart failure, 21(4), 482-491 (2019-01-25)

Atrial fibrillation is the most prevalent sustained arrhythmia associated with arrhythmic ventricular contractions, incident heart failure, increased morbidity and mortality. The relationship between arrhythmic contractions and ventricular remodelling is incompletely understood. The aim of this study was to characterize the

Structural Variations of the Prostatic Urethra Within the Prostate Predict the Severities of Obstructive Symptoms: A Prospective Multicenter Observational Study.

Young Hwii Ko et al.

Urology, 104, 160-165 (2017-03-23)

To describe distinctive morphologic variations of the prostate associated with the prostatic urethra, and to determine whether structural changes of the urethra within the prostate resulting from gland enlargement, rather than prostrate volume itself, lead to male lower urinary tract

Gene-environment interactions between HLA B7/A2, EBV antibodies are associated with MRI injury in multiple sclerosis.

Robert Zivadinov et al.

Journal of neuroimmunology, 209(1-2), 123-130 (2009-02-24)

To determine the role of gene-environmental interactions between the Class I and Class II HLA alleles and the humoral anti-Epstein-Barr Virus (EBV) responses in the development of brain injury and clinical disability in multiple sclerosis (MS) patients. A total of

Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice.

Kinga Sałat et al.

Pharmacology, biochemistry, and behavior, 122, 173-181 (2014-04-15)

Anticancer drugs - oxaliplatin (OXPT) and paclitaxel (PACLI) cause painful peripheral neuropathy activating Transient Receptor Potential (TRP) channels. Here we investigated the influence of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one (LPP1) and pregabalin on nociceptive thresholds in neuropathic pain models elicited by these drugs. Pharmacokinetics

Effect of early neonatal vitamin A supplementation on mortality during infancy in Ghana (Neovita): a randomised, double-blind, placebo-controlled trial.

Karen M Edmond et al.

Lancet (London, England), 385(9975), 1315-1323 (2014-12-17)

Results of randomised controlled trials of newborn (age 1-3 days) vitamin A supplementation have been inconclusive. The WHO is coordinating three large randomised trials in Ghana, India, and Tanzania (Neovita trials). We present the findings of the Neovita trial in

Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma.

Baoguo Ren et al.

Journal of the National Cancer Institute, 99(11), 868-880 (2007-06-07)

Integrins are the major adhesive molecules in mammalian cells. Each integrin subtype plays a unique role in cell differentiation and embryo development. However, integrin involvement in carcinogenesis has not been well defined. We identified mutations in integrin alpha7 by sequencing

Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial.

Jeffrey A Cohen et al.

Lancet (London, England), 380(9856), 1819-1828 (2012-11-06)

The anti-CD52 monoclonal antibody alemtuzumab reduced disease activity in a phase 2 trial of previously untreated patients with relapsing-remitting multiple sclerosis. We aimed to assess efficacy and safety of first-line alemtuzumab compared with interferon beta 1a in a phase 3

EGFR and erbB2 mutation status in Japanese lung cancer patients.

Hidefumi Sasaki et al.

International journal of cancer, 118(1), 180-184 (2005-07-09)

Much evidence has accumulated that the epidermal growth factor receptor (EGFR) and its family members are strongly implicated in the development and progression of lung cancers. Somatic mutations of the EGFR gene were found in about 25-40% of Japanese lung

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