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Keigo Konishi et al.
Biochemical pharmacology, 140, 150-160 (2017-06-14)
Nitrazepam (NZP) is a hypnotic agent that rarely causes liver injuries in humans and teratogenicity in rodents. In humans, NZP is primarily metabolized to 7-aminonitrazepam (ANZP) by reduction and subsequently to 7-acetylamino nitrazepam (AANZP) by acetylation. ANZP can be regenerated
Linda Tjioe et al.
Inorganic chemistry, 51(2), 939-953 (2012-01-10)
Three new metal-coordinating ligands, L(1)·4HCl [1-(2-guanidinoethyl)-1,4,7-triazacyclononane tetrahydrochloride], L(2)·4HCl [1-(3-guanidinopropyl)-1,4,7-triazacyclononane tetrahydrochloride], and L(3)·4HCl [1-(4-guanidinobutyl)-1,4,7-triazacyclononane tetrahydrochloride], have been prepared via the selective N-functionalization of 1,4,7-triazacyclononane (tacn) with ethylguanidine, propylguanidine, and butylguanidine pendants, respectively. Reaction of L(1)·4HCl with Cu(ClO(4))(2)·6H(2)O in basic aqueous solution
Hong-Ying Ma et al.
Toxicology in vitro : an international journal published in association with BIBRA, 44, 280-286 (2017-06-26)
DDAB (6,8-dichloro-9,9-dimethyl-7-oxo-7,9-dihydroacridin-2-yl benzoate) is a newly developed near-infrared fluorescent probe for human carboxylesterase 2 (hCE2), exhibiting high specificity and good reactivity for real-time monitoring the enzymatic activities of hCE2 in complex biological systems. In order to explore the applicability of
Oscar B Torres et al.
Analytical and bioanalytical chemistry, 410(16), 3885-3903 (2018-04-21)
We describe for the first time a method that utilizes microscale thermophoresis (MST) technology to determine polyclonal antibody affinities to small molecules. Using a novel type of heterologous MST, we have accurately measured a solution-based binding affinity of serum antibodies
M-C Chang et al.
Acta biomaterialia, 8(3), 1380-1387 (2011-09-29)
Biocompatibility of dentin bonding agents (DBA) and composite resin may affect the treatment outcome (e.g., healthy pulp, pulpal inflammation, pulp necrosis) after operative restoration. Bisphenol-glycidyl methacrylate (BisGMA) is one of the major monomers present in DBA and resin. Prior studies
Nele Steens et al.
Dalton transactions (Cambridge, England : 2003), (2)(2), 585-592 (2009-12-22)
Hydrolysis of 4-nitrophenyl phosphate (NPP) and bis-4-nitrophenyl phosphate (BNPP), two commonly used DNA model substrates, was examined in vanadate solutions by means of (1)H, (31)P and (51)V NMR spectroscopy. The hydrolysis of the phosphoester bond in NPP at 50 degrees
Jasleen K Sodhi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(6), 908-915 (2015-04-08)
GDC-0834, a Bruton's tyrosine kinase inhibitor investigated as a potential treatment of rheumatoid arthritis, was previously reported to be extensively metabolized by amide hydrolysis such that no measurable levels of this compound were detected in human circulation after oral administration.
Meng Zhao et al.
Dalton transactions (Cambridge, England : 2003), 41(15), 4469-4476 (2012-02-23)
Two N-donor ligands (L(1) and L(2)) derived from a β-cyclodextrin (βCD) monomer and dimer were employed to mediate the hydrolytic activity and stability of the Ce(IV) ion in aqueous solution. Complexes Ce(IV)-L(1) and Ce(IV)-L(2) were prepared in situ and characterized
Yuiko Tasaki-Handa et al.
Chemistry, an Asian journal, 15(17), 2653-2659 (2020-06-06)
A novel crystalline coordination polymer containing Ce3+ and bis(4-nitrophenyl) phosphate (L), CeL3 , was synthesized and its unique transmetalation selectivities toward Yb3+ and Lu3+ in the lanthanide series were evaluated. The relatively large difference in transmetalation selectivity between the neighboring
L Chen et al.
Xenobiotica; the fate of foreign compounds in biological systems, 39(12), 955-963 (2009-10-17)
1. The objective of this study was to investigate the effects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism. 2. After oral administration of diammonium glycyrrhizinate (50 mg kg(-1)), the peak plasma concentration (C(max))
Mitsutoshi Asakura et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(4), 477-484 (2015-01-20)
The major metabolic pathway of vildagliptin in mice, rats, dogs, and humans is hydrolysis at the cyano group to produce a carboxylic acid metabolite M20.7 (LAY151), whereas the major metabolic enzyme of vildagliptin has not been identified. In the present
Allison L Phillips et al.
Toxicological sciences : an official journal of the Society of Toxicology (2019-07-04)
Organophosphate ester (OPE) flame retardants and plasticizers, consumer product additives with widespread human exposure, were evaluated for their effect on the activity of purified human liver carboxylesterase (hCE1). Four of the 15 OPEs tested had IC50 values lower than 100 nM
Hitoshi Katada et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 13(2), 249-255 (2007-11-08)
The structures of Ce(4+) complexes that are active for DNA hydrolysis were determined for the first time by X-ray crystallography. The crystals were prepared from a 1:2 mixture of Ce(NH(4))(2)(NO(3))(6) and dipicolinic acid (2,6-pyridinedicarboxylic acid). Depending on the recrystallization conditions
Altan Ercan et al.
Journal of inorganic biochemistry, 104(1), 19-29 (2009-11-03)
The dinuclear aminopeptidase from Streptomyces griseus (SgAP) and its metal derivatives catalyze the hydrolysis of the phosphoester bis(p-nitrophenyl) phosphate (BNPP) and the phosphonate ester p-nitrophenyl phenylphosphonate with extraordinary rate enhancements at pH 7.0 and 25 degrees C [A. Ercan, H.
Xiao-Yi Yi et al.
Inorganic chemistry, 49(5), 2232-2238 (2010-02-06)
The treatment of HfCl(4) with NaL(OEt) (L(OEt)(-) = [(eta(5)-C(5)H(5))Co{P(O)(OEt)(2)}(3)](-)) in nitric acid afforded L(OEt)Hf(NO(3))(3) (1). Hydrolysis of 1 in acetone/water (4:1, v/v) yielded the hydroxy-bridged dimer [(L(OEt))(2)Hf(2)(H(2)O)(4)(mu-OH)(2)][NO(3)](4) (2). The treatment of (NH(4))(2)[Ce(NO(3))(6)] with 2 equiv of NaL(OEt) in water afforded
Takaya Kurokawa et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1218-1225 (2015-05-17)
Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyldiltiazem to diltiazem
Andrea Erxleben et al.
Journal of inorganic biochemistry, 104(4), 390-396 (2009-12-29)
The interaction of the antitumoural metallocene dihalides, titanocene dichloride (Cp(2)TiCl(2)) and Titanocene Y (bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) chloride), with bis(4-nitrophenyl) phosphate (BNPP), which is a widely used model for the phosphate diester linkages in DNA, has been studied. Cp(2)TiCl(2) has been shown to
Olga E Petrova et al.
Journal of bacteriology, 197(1), 174-187 (2014-10-22)
Biofilm dispersion is a highly regulated process that allows biofilm bacteria to respond to changing environmental conditions and to disseminate to new locations. The dispersion of biofilms formed by the opportunistic pathogen Pseudomonas aeruginosa is known to require a number
Peter C Griffiths et al.
Advances in colloid and interface science, 144(1-2), 13-23 (2008-09-25)
Incorporation of d- or f-block metals into ligand systems that renders a metal complex surface-active or drives its partitioning into surfactant phases enables the localisation of chemical functionality at interfaces. This article discusses a number of fundamental aspects of these
Yan-wei Ren et al.
Dalton transactions (Cambridge, England : 2003), 40(6), 1372-1381 (2010-12-25)
A novel asymmetric phenol-based 'end-off' dinucleating ligand 2-{[(2-piperidylmethyl)amino]methyl}-4-bromo-6-[(1-methylhomopiperazine-4-yl)methyl]phenol (HL) and three dinuclear nickel(II) complexes, [Ni₂L(μ-OH)] (ClO₄)₂ (1), [Ni₂L(DNBA)₂(CH₃CN)₂]BPh₄ (2) and [Ni₂L(BPP)₂(CH₃CN)₂]BPh₄ (3) have been synthesized and characterized by a variety of techniques including: NMR, infrared and UV-vis spectroscopies, mass spectrometry
Studies on the reaction kinetics and the mechanism of hydrolysis of bis (4-nitrophenyl) phosphate (BNPP) catalyzed by oxamido-bridged dinuclear copper (II) complexes in micellar solution.
Xie J, et al.
Transition Met. Chem. (London), 28(7), 782-787 (2003)
Stef Vanhaecht et al.
Dalton transactions (Cambridge, England : 2003), 41(33), 10028-10034 (2012-05-19)
In this study we report the first example of phosphoester bond hydrolysis in 4-nitrophenyl phosphate (NPP) and bis-4-nitrophenyl phosphate (BNPP), two commonly used DNA model substrates, promoted by metal-substituted polyoxometalates (POMs). Different transition metal and lanthanide ions were incorporated into
Helen Wiersma-Koch et al.
Biochemistry, 52(51), 9167-9176 (2013-11-23)
Catalytic promiscuity, an evolutionary concept, also provides a powerful tool for gaining mechanistic insights into enzymatic reactions. Members of the alkaline phosphatase (AP) superfamily are highly amenable to such investigation, with several members having been shown to exhibit promiscuous activity
Youli Lu et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(5), 796-802 (2011-02-25)
Ethyl piperate is an effective lipid-lowering drug candidate synthesized from piperine. However, its pharmacokinetic characteristics and oral absorption process remain unclear. A liquid chromatography-tandem mass spectrometry method was applied to determine the oral bioavailability of ethyl piperate. Simulated gastrointestinal pH
Khalid Mohammed Khan et al.
Bioorganic & medicinal chemistry, 22(22), 6509-6514 (2014-12-03)
A series of Schiff base triazoles 1–25 was synthesized and evaluated for their nucleotide pyrophosphatase/phosphodiesterase-1 inhibitory activities. Among twenty-five compounds, three compounds 10 (IC50 = 132.20 ± 2.89 lM), 13 (IC50 = 152.83 ± 2.39 lM), and 22 (IC50 =
Luigi Mandrich et al.
Biochemistry, 48(24), 5602-5612 (2009-05-15)
The recent specialization for utilization of pesticides reported for Pseudomonas diminuta phosphotriesterase (pPTE) strongly suggests that this activity evolved from an enzyme endowed with promiscuous phosphotriesterase activity. Such a putative "generalist" enzyme was recently proposed to be a member of
Hitomi Ozaki et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 86, 116-123 (2015-09-01)
Salicylates are used as fragrance and flavor ingredients for foods, as UV absorbers and as medicines. Here, we examined the hydrolytic metabolism of phenyl and benzyl salicylates by various tissue microsomes and plasma of rats, and by human liver and
Chi C Wong et al.
The Journal of pharmacology and experimental therapeutics, 340(2), 422-432 (2011-11-17)
Phospho-nonsteroidal anti-inflammatory drugs (phospho-NSAIDs) are novel NSAID derivatives with improved anticancer activity and reduced side effects in preclinical models. Here, we studied the metabolism of phospho-NSAIDs by carboxylesterases and assessed the impact of carboxylesterases on the anticancer activity of phospho-NSAIDs
S Casey Laizure et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(3), 245-251 (2019-05-01)
Clopidogrel is widely prescribed in patients with cardiovascular disease. Most research has focused on the role of hepatic CYP450 metabolism as the primary source of response variability despite 85-90% of clopidogrel being hydrolyzed by human carboxylesterase-1 (CES1).The purpose of this
M P Lim et al.
Cell death & disease, 2, e170-e170 (2011-06-10)
The major cellular event in the development and progression of liver fibrosis is the activation of hepatic stellate cells (HSCs). Activated HSCs proliferate and produce excess collagen, leading to accumulation of scar matrix and fibrotic liver. As such, the induction
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