127744

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Hebeish A and El-Hilw ZH.

Journal of Applied Polymer Science, 67(4) (1998)

Ammonia as a preferred additive in chiral and achiral applications of supercritical fluid chromatography for small, drug-like molecules.

Manuel Ventura et al.

Journal of chromatography. A, 1220, 147-155 (2011-12-22)

Supercritical fluid chromatography is routinely utilized by analytical separations groups in the pharmaceutical industry to efficiently handle separations for discovery medicinal chemistry purposes. Purifications are performed on samples ranging from a few milligrams up to hundreds of grams. Basic additives

Interaction of naproxen amphiphilic derivatives with biomembrane models evaluated by differential scanning calorimetry and Langmuir-Blodgett studies.

Dorotea Micieli et al.

Journal of colloid and interface science, 360(2), 359-369 (2011-05-24)

Anti-inflammatory drugs represent a potential new strategy for the treatment of Alzheimer's disease (AD). The ability to cross the blood-brain barrier and to reach brain tissues is a critical point for these drugs and is strictly related to their lipophilicity.

6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds.

Junzo Hirano et al.

Journal of fluorescence, 20(2), 615-624 (2010-01-29)

A novel fluorescence enhancement-type derivatizing reagent for amino compounds, 6,7-difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid (FMQC), was developed. FMQC reacts with aliphatic primary amino compounds to afford strong fluorescent derivatives having high photo-and thermo-stabilities. The FMQC derivatives of amino compounds showed 12-159 times higher

Chronic administration of the HNO donor Angeli's salt does not lead to tolerance, cross-tolerance, or endothelial dysfunction: comparison with GTN and DEA/NO.

Jennifer C Irvine et al.

Antioxidants & redox signaling, 14(9), 1615-1624 (2010-09-21)

Nitroxyl (HNO) displays distinct pharmacology to its redox congener nitric oxide (NO(•)) with therapeutic potential in the treatment of heart failure. It remains unknown if HNO donors are resistant to tolerance development following chronic in vivo administration. Wistar-Kyoto rats received

Determination of sulfonamides in swine muscle after salting-out assisted liquid extraction with acetonitrile coupled with back-extraction by a water/acetonitrile/dichloromethane ternary component system prior to high-performance liquid chromatography.

Wen-Hsien Tsai et al.

Journal of chromatography. A, 1217(3), 250-255 (2009-12-05)

A salting-out assisted liquid extraction coupled with back-extraction by a water/acetonitrile/dichloromethane ternary component system combined with high-performance liquid chromatography with diode-array detection (HPLC-DAD) was developed for the extraction and determination of sulfonamides in solid tissue samples. After the homogenization of

Ring substituents on substituted benzamide ligands indirectly mediate interactions with position 7.39 of transmembrane helix 7 of the D4 dopamine receptor.

Spencer S Ericksen et al.

The Journal of pharmacology and experimental therapeutics, 342(2), 472-485 (2012-05-17)

In an effort to delineate how specific molecular interactions of dopamine receptor ligand classes vary between D2-like dopamine receptor subtypes, a conserved threonine in transmembrane (TM) helix 7 (Thr7.39), implicated as a key ligand interaction site with biogenic amine G

Application of various methods for removal of polycyclic aromatic hydrocarbons from synthetic solid matrices.

Gizem Karaca et al.

Environmental technology, 35(13-16), 1840-1850 (2014-06-25)

In the present study, removal of polycyclic aromatic hydrocarbons (PAHs) from synthetic solid matrices with various methods was investigated. PAH removal experiments were conducted in a specifically designed UV apparatus for this study. Polyurethane foams (PUF) cartridges were used to

Adsorption of polar and nonpolar compounds onto complex nanooxides with silica, alumina, and titania.

V M Gun'ko et al.

Journal of colloid and interface science, 348(2), 546-558 (2010-07-14)

Adsorption of low-molecular adsorbates (nonpolar hexane, nitrogen, weakly polar acetonitrile, and polar diethylamine, triethylamine, and water) onto individual (silica, alumina, titania), binary (silica/alumina (SA), silica/titania (ST)), and ternary (alumina/silica/titania, AST) fumed oxides was studied to analyse the effects of morphology

TLC and HPLC methods to follow the synthesis of vinorelbine.

Zhao Chunfang et al.

Journal of chromatographic science, 48(8), 685-689 (2010-09-08)

The thin-layer chromatography (TLC) combined with high-performance liquid chromatography (HPLC) has been proved to be a quick and valid method to detect the intermediates and the end-product created during the chemosynthesis process of vinorelbine (VB). This paper gives a detailed

Bicellar systems for in vitro percutaneous absorption of diclofenac.

L Rubio et al.

International journal of pharmaceutics, 386(1-2), 108-113 (2009-11-20)

This work evaluates the effect of different bicellar systems on the percutaneous absorption of diclofenac diethylamine (DDEA) using two different approaches. In the first case, the drug was included in bicellar systems, which were applied on the skin and, in

Synchrony of G6PD activity and RBC fragility under oxidative stress exerted at normal and G6PD deficiency.

Muayad M Abboud et al.

Clinical biochemistry, 43(4-5), 455-460 (2009-11-28)

To investigative the effects of oxidative stress simultaneously on Glucose-6-phosphate dehydrogenase (G6PD) activity and RBC fragility under normal and G6PD defective conditions. The effects of several nitric oxide (NO) generating compounds and sulfhydryl blocking agents were simultaneously tested in vitro

Isolation and characterization of degradation products of citalopram and process-related impurities using RP-HPLC.

Ramisetti Nageswara Rao et al.

Journal of separation science, 31(10), 1729-1738 (2008-05-16)

A reversed-phase high-performance liquid chromatographic method for simultaneous separation and determination of citalopram hydrobromide and its process impurities in bulk drugs and pharmaceutical formulations was developed. The separation was accomplished on an Inertsil ODS 3V (250x4.6 mm; particle size 5

Process optimisation for anion exchange monolithic chromatography of 4.2kbp plasmid vaccine (pcDNA3F).

Clarence M Ongkudon et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(28), 2719-2725 (2010-09-03)

Anion exchange monolithic chromatography is increasingly becoming a prominent tool for plasmid DNA purification but no generic protocol is available to purify all types of plasmid DNA. In this work, we established a simple framework and used it to specifically

Highly selective and sensitive DNA assay based on electrocatalytic oxidation of ferrocene bearing zinc(II)-cyclen complexes with diethylamine.

Muhammad J A Shiddiky et al.

Journal of the American Chemical Society, 132(29), 10053-10063 (2010-07-06)

A highly selective and sensitive electrochemical biosensor has been developed that detects DNA hybridization by employing the electrocatalytic activity of ferrocene (Fc) bearing cyclen complexes (cyclen = 1,4,7,10-tetraazacyclododecane, Fc[Zn(cyclen)H(2)O](2)(ClO(4))(4) (R1), Fc(cyclen)(2) (R2), Fc[Zn(cyclen)H(2)O](ClO(4))(2) (R3), and Fc(cyclen) (R4)). A sandwich-type approach

Synthesis, antidiabetic and hypolipidemic activities of new diethylamine and triethoxysilyl derivatives of tolbutamide on rats.

Abbas Ahmadi et al.

Medicinal chemistry (Shariqah (United Arab Emirates)), 8(5), 964-969 (2012-06-30)

Tolbutamide (N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide, CAS 64-77-7, I) is the first generation of potassium channel blocker and sulfonylurea oral hypoglycemic drug that imparts marked blood glucose lowering effect in type 2 diabetes or non-insulin dependent diabetes mellitus (NIDDM) patients. In this study, I

Preparation of sub-micron skeletal monoliths with high capacity for liquid chromatography.

Chunhe Yao et al.

Journal of separation science, 33(4-5), 475-483 (2010-01-12)

A novel kind of poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate)-based monolithic column was developed for LC by directing supramolecular self-assembly of high internal phase emulsion. Mercury intrusion porosimetry characterization and scanning electron microscope pictures showed that these monoliths presented micrometer-sized throughpores, unique

Functional studies of the effect of NO donor on human CLCN1 polymorphism/mutants expressed in Xenopus laevis oocytes.

Min-Jon Lin et al.

Biochemical and biophysical research communications, 365(4), 724-728 (2007-11-24)

In this study, we investigated the effect of NO donor, diethylamine/nitric oxide (DEA/NO), on the electrophysiological behavior of human skeletal muscle chloride channel (CLCN1). The wild-type and variants of CLCN1, including one polymorphism (P727L) and four mutants (T631I, D644G, G482R

The effect of surface charge property on Escherichia coli initial adhesion and subsequent biofilm formation.

Akihiko Terada et al.

Biotechnology and bioengineering, 109(7), 1745-1754 (2012-01-18)

Polyethylene (PE) sheets were modified by radiation-induced graft polymerization (RIGP) of an epoxy-group containing monomer glycidyl methacrylate (GMA). The epoxy group of GMA was opened by introducing sodium sulfite (SS) and diethylamine (DEA) as representatives of negatively and positively charged

Enantioresolution of basic pharmaceuticals using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral stationary phase and polar organic mobile phases.

Katina S S Dossou et al.

Journal of chromatography. A, 1216(44), 7450-7455 (2009-06-26)

A polysaccharide-based chiral stationary phase (Sepapak-4), with cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral selector, has been investigated in liquid chromatography (LC). Its enantioresolution power was evaluated towards 13 basic amino-drugs with widely different structures and polarities, using polar organic mobile phases. After

Perturbing effects of chiral stationary phase on enantiomerization second-order rate constants determined by enantioselective dynamic high-performance liquid chromatography: a practical tool to quantify the accessible acid and basic catalytic sites bonded on chromatographic supports.

Roberto Cirilli et al.

Analytical chemistry, 81(9), 3560-3570 (2009-03-28)

Second-order rate constants of the diethylamine-promoted enantiomerization of 2-[2-(1-methyl-1H-pyrrol-2-yl)-2-oxo-1-phenylethyl]-isoindole-1,3-dione, a chiral alpha-substituted ketone endowed with high anti-MAO activity type-A, were measured by dynamic high-performance liquid chromatography (DHPLC), stopped-flow high-performance liquid chromatography (sf-HPLC), and a classical method based on enantioselective HPLC

Effect of rubbing on the in vitro skin permeation of diclofenac-diethylamine 1.16% gel.

Nathalie Hasler-Nguyen et al.

BMC research notes, 5, 321-321 (2012-06-23)

Rubbing a topical NSAID (non steroidal anti-inflammatory drug) on the skin may increase local drug permeation, affecting its distribution to the site of pain and inflammation. The present study evaluates this hypothesis, by assessing in vitro the effect on skin

In vitro permeation of diclofenac salts from lyotropic liquid crystalline systems.

Doron Yariv et al.

Colloids and surfaces. B, Biointerfaces, 78(2), 185-192 (2010-04-07)

In this paper we examined feasible correlations between the structure of different lyotropic mesophases and transdermal administration of three diclofenac derivatives with varying degrees of kosmotropic or chaotropic properties, solubilized within the mesophases. It was found that the most chaotropic

Reaction of iminopropadienones with amines--formation of zwitterionic intermediates, ketenes, and ketenimines.

Rakesh Naduvile Veedu et al.

The journal of physical chemistry. A, 112(40), 9742-9750 (2008-09-16)

Five aryliminopropadienones 4a- d have been synthesized by flash vacuum thermolysis (FVT) by using two different precursors in each case. These compounds were deposited at 50 K at a pressure of ca. 10(-6) mbar together with three different nucleophiles, namely

Toxicology and carcinogenesis studies of diethylamine (CAS No. 109-89-7) in F344/N rats and B6C3F1 mice (inhalation studies).

National Toxicology Program technical report series, (566)(566), 1-174 (2011-12-01)

Diethylamine is used mainly as a chemical intermediate to produce the corrosion inhibitor N,N-diethylethanolamine and a lesser amount is used to produce pesticides and insect repellants and in rubber processing. Diethylamine was nominated for study by the National Institute of

Direct photoreduction and ketone-sensitized reduction of nitrospirobenzopyranindolines by aliphatic amines.

Helmut Görner

The journal of physical chemistry. A, 115(29), 8208-8215 (2011-06-22)

The photoreduction of 6-nitrospiro[2H-1-benzopyran-2,2'-indoline] (N1) and two derivatives (N2 and N3) by diethylamine or triethylamine (TEA) in solution was studied by pulsed and steady-state photolysis. The quantum yield of coloration of the ring-closed Sp form, due to photoinduced ring opening

Determination of polycyclic aromatic hydrocarbons in solid matrices using automated cold fiber headspace solid phase microextraction technique.

Jun Guo et al.

Journal of chromatography. A, 1307, 66-72 (2013-08-15)

The extraction efficiency of analytes in a cold fiber headspace solid-phase microextraction (CF-HS-SPME) system was investigated both theoretically and experimentally. The system was applied for quantitative extraction of polycyclic aromatic hydrocarbons (PAHs) from solid matrices. In order to achieve better

A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.

Touran Zarrabi et al.

The Journal of biological chemistry, 285(50), 39458-39470 (2010-10-12)

Voltage-gated ion channels are transmembrane proteins that undergo complex conformational changes during their gating transitions. Both functional and structural data from K(+) channels suggest that extracellular and intracellular parts of the pore communicate with each other via a trajectory of

Excess no predisposes mitochondrial succinate-cytochrome c reductase to produce hydroxyl radical.

Jingfeng Chen et al.

Biochimica et biophysica acta, 1807(5), 491-502 (2011-03-17)

Mitochondria-derived oxygen-free radical(s) are important mediators of oxidative cellular injury. It is widely hypothesized that excess NO enhances O(2)(•-) generated by mitochondria under certain pathological conditions. In the mitochondrial electron transport chain, succinate-cytochrome c reductase (SCR) catalyzes the electron transfer

Synthesis and application of ionic liquid matrices (ILMs) for effective pathogenic bacteria analysis in matrix assisted laser desorption/ionization (MALDI-MS).

Hani Nasser Abdelhamid et al.

Analytica chimica acta, 767, 104-111 (2013-03-05)

Application of two new series of ionic liquid matrices (ILMs) based on the two most predominantly used conventional organic matrices (Sinapinic acid and 2,5-DHB) in conjugation with various bases (aniline (ANI), dimethyl aniline (DMANI), diethylamine (DEA), dicyclohexylamine (DCHA), pyridine (Pyr)

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